Experience

McLaughlin Research Institute

• United States
• Research Services
• 1 - 100 Employee

• Assistant Professor

  • Aug 2022 - Present



Duke University

• United States
• Higher Education
• 700 & Above Employee

• • Sep 2020 - Aug 2022

  Research on age-related macular degeneration (AMD), specifically the role of exosomes and other extracellular vesicles in pathobiological mechanisms in the Retinal Pigmented Epithelium (RPE) and Bruch's membrane.References:1: High density lipoproteins are a potential therapeutic target for age-related macular degeneration. Kelly UL, Grigsby D, Cady MA, Landowski M, Skiba NP, Liu J, Remaley AT, Klingeborn M, Bowes Rickman C. J Biol Chem. 2020 Jul 31:jbc.RA119.012305. doi: 10.1074/jbc.RA119.012305. PMID:327372032: Isolation of Retinal Exosome Biomarkers from Blood by Targeted Immunocapture. Klingeborn M, Skiba NP, Stamer WD, Bowes Rickman C. Adv Exp Med Biol. 2019;1185:21-25. doi: 10.1007/978-3-030-27378-1_4. PMID:318845833: Microglia are not required for prion-induced retinal photoreceptor degeneration. Striebel JF, Race B, Williams K, Carroll JA, Klingeborn M, Chesebro B. Acta Neuropathol Commun. 2019 Mar 25;7(1):48. doi: 10.1186/s40478-019-0702-x. PMID:30909963 4: Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration. O'Koren EG, Yu C, Klingeborn M, Wong AYW, Prigge CL, Mathew R, Kalnitsky J, Msallam RA, Silvin A, Kay JN, Bowes Rickman C, Arshavsky VY, Ginhoux F, Merad M, Saban DR. Immunity. 2019 Mar 19;50(3):723-737.e7. doi: 10.1016/j.immuni.2019.02.007. PMID:308503445: Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP, Deshaies RJ, Arshavsky VY. Nat Commun. 2018 Apr 30;9(1):1738. doi: 10.1038/s41467-018-04117-8. PMID:29712894.6: Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers. Klingeborn M, Dismuke WM, Skiba NP, Kelly U, Stamer WD, Bowes Rickman C. Sci Rep. 2017 Jul 7;7(1):4901. doi:10.1038/s41598-017-05102-9. PMID:28687758. Show less

• • Feb 2012 - Sep 2020

  Research on age-related macular degeneration (AMD), specifically the role of exosomes and other extracellular vesicles in pathobiological mechanisms in the retinal pigment epithelium (RPE) and Bruch's membrane.References:1: Klingeborn M, Stamer WD, Bowes Rickman C. Polarized Exosome Release from theRetinal Pigmented Epithelium. Adv Exp Med Biol. 2018;1074:539-544. doi:10.1007/978-3-319-75402-4_65. PubMed PMID: 29721985.2: Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP,Deshaies RJ, Arshavsky VY. Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. Nat Commun. 2018 Apr 30;9(1):1738.doi: 10.1038/s41467-018-04117-8. PubMed PMID: 29712894; PubMed Central PMCID:PMC5928105.4: Klingeborn M, Dismuke WM, Skiba NP, Kelly U, Stamer WD, Bowes Rickman C.Directional Exosome Proteomes Reflect Polarity-Specific Functions in RetinalPigmented Epithelium Monolayers. Sci Rep. 2017 Jul 7;7(1):4901. doi:10.1038/s41598-017-05102-9. PubMed PMID: 28687758; PubMed Central PMCID:PMC5501811.5: Klingeborn M, Dismuke WM, Bowes Rickman C, Stamer WD. Roles of exosomes in thenormal and diseased eye. Prog Retin Eye Res. 2017 Jul;59:158-177. doi:10.1016/j.preteyeres.2017.04.004. Epub 2017 Apr 29. Review. PubMed PMID:28465248; PubMed Central PMCID: PMC5537591.6: Dismuke WM, Klingeborn M, Stamer WD. Mechanism of Fibronectin Binding to HumanTrabecular Meshwork Exosomes and Its Modulation by Dexamethasone. PLoS One. 2016 Oct 26;11(10):e0165326. doi: 10.1371/journal.pone.0165326. eCollection 2016.PubMed PMID: 27783649; PubMed Central PMCID: PMC5081181. Show less



University of North Carolina at Chapel Hill

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Associate

  • Jun 2011 - Jan 2012

  Research on HIV and Hepatitis C using a co-infection model. We use the novel AFC8-hu mouse, which has a chimeric human liver and engrafted human immune system and is permissive for HCV replication and human liver fibrosis induction, to study the effect of HIV co-infection on HCV-induced liver fibrosis in vivo. No other animal model supports HIV/HCV co-infection and allows these interactions to be studied in vivo under controlled conditions (1-3). 1. E. Dolgin, Nature 474, S14 (Jun 9, 2011). 2. E. Robinet, T. F. Baumert, J Hepatol 55, 718 (Sep, 2011). 3. M. L. Washburn et al., Gastroenterology, (Jan 12, 2011). Show less



NIH/NIAID/Rocky Mountain Laboratories

• Visiting Fellow

  • Aug 2007 - May 2011

  Research on mad cow disease and other prion diseases. References: 1: Rangel A, Race B, Klingeborn M, Striebel J, Chesebro B. Unusual cerebral vascular prion protein amyloid distribution in scrapie-infected transgenic mice expressing anchorless prion protein. Acta Neuropathol Commun. 2013 Jun 19;1:25. doi: 10.1186/2051-5960-1-25. PubMed PMID: 24252347; PubMed Central PMCID: PMC3893542. 2: Klingeborn M, Race B, Meade-White KD, Chesebro B. Lower specific infectivity of protease-resistant prion protein generated in cell-free reactions. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):E1244-53. doi: 10.1073/pnas.1111255108. Epub 2011 Nov 7. PubMed PMID: 22065744; PubMed Central PMCID: PMC3228482. 3: Klingeborn M, Race B, Meade-White KD, Rosenke R, Striebel JF, Chesebro B. Crucial role for prion protein membrane anchoring in the neuroinvasion and neural spread of prion infection. J Virol. 2011 Feb;85(4):1484-94. doi: 10.1128/JVI.02167-10. Epub 2010 Dec 1. PubMed PMID: 21123371; PubMed Central PMCID: PMC3028874. 4: Chesebro B, Race B, Meade-White K, Lacasse R, Race R, Klingeborn M, Striebel J, Dorward D, McGovern G, Jeffrey M. Fatal transmissible amyloid encephalopathy: a new type of prion disease associated with lack of prion protein membrane anchoring. PLoS Pathog. 2010 Mar 5;6(3):e1000800. doi: 10.1371/journal.ppat.1000800. PubMed PMID: 20221436; PubMed Central PMCID: PMC2832701. Show less



SLU - Swedish University of Agricultural Sciences

• Sweden
• Higher Education
• 700 & Above Employee

• PhD student

  • Jan 2001 - Dec 2006

  PhD studies in prion biology. Research on mad cow disease, scrapie and Nor98. PhD studies in prion biology. Research on mad cow disease, scrapie and Nor98.