Michael A. Evans, PhD
Senior Scientist, LNP Formulation Development at Senda Biosciences- Claim this Profile
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Bio
Experience
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Senda Biosciences
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United States
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Biotechnology Research
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1 - 100 Employee
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Senior Scientist, LNP Formulation Development
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Aug 2022 - Present
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Poseida Therapeutics, Inc.
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United States
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Biotechnology Research
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200 - 300 Employee
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Scientist II Nanoparticle Formulations and Platform Development (Lipid Nanoparticles)
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Aug 2021 - Aug 2022
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Scientist I Nonviral Gene Therapy
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Sep 2019 - Aug 2021
Greater San Diego Area
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Indee Labs
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United States
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Biotechnology Research
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1 - 100 Employee
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Independent Consultant
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Dec 2018 - Nov 2019
Research to establish methods to culture various types of cells In depth analysis of the commercial potential of up and coming cell therapies
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Harvard John A. Paulson School of Engineering and Applied Sciences
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United States
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Higher Education
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300 - 400 Employee
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PHD Candidate
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Aug 2017 - Sep 2019
Greater Boston Area Continuing the work started at UCSB with Dr. Samir Mitragotri on utilizing macrophages as drug delivery vehicles Utilized macrophages as drug delivery vehicles to enhance the targeting of cancer therapeutics, demonstrating the ability of macrophages to transport photoactivated nitric oxide deep into tumor spheroids reducing the expression of HIF-1α, a protein with a major role in tumor resistance to chemo and radiotherapy, by 28%. Two more macrophage-based delivery projects are… Show more Continuing the work started at UCSB with Dr. Samir Mitragotri on utilizing macrophages as drug delivery vehicles Utilized macrophages as drug delivery vehicles to enhance the targeting of cancer therapeutics, demonstrating the ability of macrophages to transport photoactivated nitric oxide deep into tumor spheroids reducing the expression of HIF-1α, a protein with a major role in tumor resistance to chemo and radiotherapy, by 28%. Two more macrophage-based delivery projects are underway one of which is able to overcome the poor tumor penetration of the hypoxic prodrug, tirapazamine, and increase its efficacy up to 3-fold in vivo. Helped design drug conjugates with controlled release rates for drug scheduling. Enabling two different platforms to improve tumor regression in vivo with one causing the disappearance of tumors in 62% of treated mice. Show less
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UC Santa Barbara
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Higher Education
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700 & Above Employee
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Graduate Researcher
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Aug 2014 - Aug 2017
Santa Barbara, California Area Working under Dr. Samir Mitragotri and Dr. Peter Ford to develop methods to utilize macrophages as drug delivery vehicles. Work was continued upon moving to Harvard (for more detail see description under Harvard University)
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Furman University
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Researcher
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May 2012 - May 2014
Greenville, South Carolina Area Worked under Dr. Tim Hanks on the development of biosensing diacetylene liposomes fabricated via inkjet technology with the ability to detect different types of bacteria via colorimetric and fluorescent changes. Led research in liposome system optimization and synthesis of molecules to be incorporated into liposomes for bacterial sensing
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Education
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Harvard University
Doctor of Philosophy - PhD, Nanotechnology -
University of California, Santa Barbara
Master of Science - MS, Chemistry and Biochemistry -
Furman University
Bachelor of Science - BS, Chemistry