Experience

Northwestern University

• United States
• Higher Education
• 700 & Above Employee

• Research Associate

  • Dec 2019 - Present

  • Executed a study exploring how AZD1775, the FDA-approved WEE1 inhibitor modulates anti-tumor immune response in breast cancer. • Conducted a collaboration study for nano vaccine project at Northwestern University. The study showed that proteomimetic peptide delivery platform (protein-like-polymers) allowed efficient induction of antigen-specific anti-tumor immune response, limiting tumor growth.

• Research Associate

  • Oct 2013 - Nov 2019

  • Established optimal protocol for the preparation of human breast organoid and for long-term culture condition, maintaining expression of hormone receptors in organoids. • Constructed a small repository for human breast organoids (200-300 patients). Provided the collaborators human breast organoids for the research. • Established CRISPR-Cas9 gene editing system for brca1 gene in cells/organoids and developed a novel quantification method for the mutation burden. • Established APOBEC… Show more • Established optimal protocol for the preparation of human breast organoid and for long-term culture condition, maintaining expression of hormone receptors in organoids. • Constructed a small repository for human breast organoids (200-300 patients). Provided the collaborators human breast organoids for the research. • Established CRISPR-Cas9 gene editing system for brca1 gene in cells/organoids and developed a novel quantification method for the mutation burden. • Established APOBEC transgenic mouse model. Using the preliminary data from the transgenic mice study NADAC-Lung Cancer Proposal with collaborators was awarded. • Contributed to the study to identify a gene panel in breast epithelium for predicting risk in estrogen receptor negative breast cancer, and characterized the pioneer factor PBX1 as a potential master regulator of this gene set. • Contributed to the study that discovered the blockade of progesterone receptor in human breast cancer cells using the antagonists led to decreasing cell cycle genes.



Indiana University School of Medicine

• Research Services
• 700 & Above Employee

• Assistant Research Scientist

  • May 2011 - Sep 2013

• Postdoctoral Fellow

  • Mar 2006 - Apr 2011

  • Established in vivo mouse model for tumor lesion (orthotopic and brain metastases of breast tumor)-specific delivery of immune cells loaded with nanoparticles. • Contributed to establish the Komen Tissue Bank (KTB) at Indiana University Simon Cancer Center as a collaborating team member. • Contributed to characterize transcriptome of normal and triple-negative breast cancer using normal breast tissue provided by KTB. • Contributed to in vitro studies using normal breast epithelial… Show more • Established in vivo mouse model for tumor lesion (orthotopic and brain metastases of breast tumor)-specific delivery of immune cells loaded with nanoparticles. • Contributed to establish the Komen Tissue Bank (KTB) at Indiana University Simon Cancer Center as a collaborating team member. • Contributed to characterize transcriptome of normal and triple-negative breast cancer using normal breast tissue provided by KTB. • Contributed to in vitro studies using normal breast epithelial cells, revealing multiplasticity in phenotype.



Indiana University School of Medicine, Pharmacology and Toxicology

• Indianapolis, Indiana, United States

• Postdoctoral Fellow

  • Sep 2003 - Feb 2006

  • Investigated changes in whole proteome in apoptotic leukemia cells triggered by proteasome inhibitor, PSI and identified functional implication of caspase-mediated RhoGDI2 processing. • Characterized apoptotic multidrug resistant cancer cells triggered by TRAIL and Taxol by in vitro cell-based assays. • Investigated changes in whole proteome in apoptotic leukemia cells triggered by proteasome inhibitor, PSI and identified functional implication of caspase-mediated RhoGDI2 processing. • Characterized apoptotic multidrug resistant cancer cells triggered by TRAIL and Taxol by in vitro cell-based assays.