Experience

BAKX Therapeutics
• United States
• Biotechnology
• 1 - 100 Employee
• Head of Discovery Biology

  • Jun 2021 - Present


Silicon Therapeutics

• Director, Biology

  • Feb 2021 - Present

• Associate Director, Biology

  • Jun 2019 - Jan 2021

• Principal Investigator, Discovery

  • Feb 2018 - Jun 2019



AstraZeneca

• United Kingdom
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Senior Scientist

  • May 2015 - Feb 2018

  • Biology lead of 2 drug discovery programs (an Immuno-Oncology program targeting a Kinase and an Oncogenic Epigenetic modulator) • Develop overall strategy and lead implementation of the cascade for identification of small molecule inhibitors • Document, analyze and summarize findings to cross-functional project team (Biology, Chemistry, DMPK, Translational Science) as well as executive management teams to drive strategic decisions for the project • Lead pre-clinical bioscience studies: - Interrogate target biology using integrated cellular, molecular and genomic approaches - Develop cellular MoA assays to assess Target Engagement and support SAR for small-molecule selection - Establish human and mouse immune cell assays for target validation and functional PD assessment - Identify and characterize models (xenograft, syngeneic, PDX) for in vivo PK/PD/Efficacy studies and develop biomarker strategy for patient stratification - Generate data package to provide differentiation from competitor programs • Initiate and manage research collaborations with CROs and academic partners to conduct genome-wide and focused CRISPR screens (CRISPRN, CRISPRi) for identification of novel targets and mechanisms of resistance/response for targeted agents in the Oncology pipeline. • Evaluate new targets, screening platforms & technologies, collaborations and licensing opportunities as part of global team to bring forward new projects to governance Show less



Belfer Institute for Applied Cancer Science

• Biotechnology Research
• 1 - 100 Employee

• Research Scientist II, Target Discovery & Validation

  • Feb 2013 - Apr 2015

  • Target ID & Validation: Lead a multidisciplinary effort aimed at identifying and functionally validating novel targets for cancer therapy using oncogenomics, in vitro and in vivo RNAi screens in human tumor xenografts and in vitro cell-based assays.• Assay Development: Design, develop and implement robust screening platforms for discovery & assessment of oncogenic targets, in vitro and in vivo, using genome engineering tools including RNAi and CRISPR/Cas9 based technologies.• Plan and design studies with industry partners, report data to joint research teams.• Successfully train, mentor and manage Ph.D. and non-Ph.D. scientists.• Nominate new drug targets for collaboration portfolios with pharmaceutical industry partners Show less

• Research Scientist I

  • Feb 2012 - Jan 2013


Department of Genetics, Harvard Medical School
• Postdoctoral Research Fellow

  • Feb 2010 - Jan 2012

Howard Hughes Medical Institute, Harvard Medical School
• Postdoctoral Research Fellow

  • Feb 2004 - Jan 2010