Max Ezekiel
Associate Scientist II, AAV Process Development at Apertura Gene Therapy- Claim this Profile
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English Native or bilingual proficiency
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Spanish Limited working proficiency
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Experience
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Apertura Gene Therapy
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United States
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Biotechnology Research
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1 - 100 Employee
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Associate Scientist II, AAV Process Development
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Aug 2022 - Present
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Northwestern University
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Philippines
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Higher Education
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1 - 100 Employee
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Graduate Student Researcher
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Sep 2020 - Jun 2022
- Designed and executed long-term experiments that culminated in a successfully defended thesis. - Engineered orthogonal synthetic receptors and tested how changing domains effects ligand-based response. - Collaborated with a team to design a roadmap for orthogonal receptor engineering in a work to be published. - Designed and executed long-term experiments that culminated in a successfully defended thesis. - Engineered orthogonal synthetic receptors and tested how changing domains effects ligand-based response. - Collaborated with a team to design a roadmap for orthogonal receptor engineering in a work to be published.
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ElevateBio
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United States
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Biotechnology Research
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200 - 300 Employee
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Process Development Engineer II
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Sep 2019 - Sep 2020
- Developing upstream process for Lentivirus and AAV. - Transfering platform into a GMP environment. - Setting up both a process development and GMP lab space for capsid development and production. - Operation and Organization of instrumentation essential to running said process. - Developing upstream process for Lentivirus and AAV. - Transfering platform into a GMP environment. - Setting up both a process development and GMP lab space for capsid development and production. - Operation and Organization of instrumentation essential to running said process.
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Casebia Therapeutics
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United States
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Biotechnology
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1 - 100 Employee
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AAV Process Development Engineer
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Feb 2018 - Sep 2019
Developed platform process for consistent, scalable production of multiple AAV serotypes from adherent and suspension HEK293 systems from a 40mL - 50L scale. - Developed process of growth and AAV production for the following reactor systems: Sartorius AMBR250, Eppendorf 10c, GE WAVE, Thermo 50L Sub. - Took a lead in upstream process development work in optimizing yield from a licensed cell line. - Wrote detailed SOPs/SBRs that led to successful production in CMOs. - Aided in development of quantification methods (qPCR, ELISA, Silver) and purification of multiple AAV serotypes. - As part of a 4-person team that has grown to 22 people, has aided in not only personnel acquisition and development, but also filling in gaps in an lean group. Show less
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Pfizer
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Events Services
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1 - 100 Employee
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Associate Scientist
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Aug 2016 - Feb 2018
- Optimizing cell culture media for growth and production by manipulating its components and processes in a team lab environment. - Designing and executing experiments and presenting the results. - Instrumentation includes Mammalian bioreactors, shake flasks, AMBR system, High Performance Liquid Chromatography, Ultra Performance Liquid Chromatography, Amino Acid Analysis, Bio HT Analyzer, Nanodrop, and Packed Columns. - Contributed research for patent defense. - Optimizing cell culture media for growth and production by manipulating its components and processes in a team lab environment. - Designing and executing experiments and presenting the results. - Instrumentation includes Mammalian bioreactors, shake flasks, AMBR system, High Performance Liquid Chromatography, Ultra Performance Liquid Chromatography, Amino Acid Analysis, Bio HT Analyzer, Nanodrop, and Packed Columns. - Contributed research for patent defense.
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Product Stewardship Intern
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Jun 2014 - Aug 2014
-Product Stewardship Intern. Worked on a consulting project for a large, confidential client working to reduce their footprint. -As part of a team, navigated through MSDS forms to determine the eligibility of over 20,000 chemicals. -Product Stewardship Intern. Worked on a consulting project for a large, confidential client working to reduce their footprint. -As part of a team, navigated through MSDS forms to determine the eligibility of over 20,000 chemicals.
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Zappix
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United States
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Software Development
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1 - 100 Employee
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Software Intern
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Jun 2012 - Aug 2012
-Software developer in a start-up company working to navigate through phone trees for the client. -Responsible for dealing with customer call trees and programming results. -Software developer in a start-up company working to navigate through phone trees for the client. -Responsible for dealing with customer call trees and programming results.
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Massachusetts General Hospital
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United States
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Hospitals and Health Care
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700 & Above Employee
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Laboratory Assistant
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Jun 2010 - Aug 2010
-Research Lab Assistant. Worked in a lab researching cystic fibrosis through Pseudomonas in zebra fish. -Responsible for preparing various solutions and plates, aiding in procedural experimentations, and performing data analysis on Microsoft Office -Research Lab Assistant. Worked in a lab researching cystic fibrosis through Pseudomonas in zebra fish. -Responsible for preparing various solutions and plates, aiding in procedural experimentations, and performing data analysis on Microsoft Office
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Education
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Northwestern University
Master of Science - MS, Chemical Engineering -
Tufts University
Bachelor of Science - BS, Chemical Engineering; BS, Biotechnology -
Newton South High School
High School