Experience

F-star, an invoX company

• United Kingdom
• Biotechnology
• 1 - 100 Employee

• CMC manager

  • Jul 2022 - Present

• Senior Scientist, CMC lead

  • Jun 2020 - Aug 2022

• Group Leader

  • Sep 2018 - Jun 2020

  Leading F-star protein production team to support multiple discovery and pre-development projects.- Scheduling and delivery of recombinant proteins- Accountable for product quality- Responsible for manufacturability assessment - Internal and external stakeholders management- Line management - Overseeing optimisation of F-star USP and DSP production capabilitiesProtein Sciences representative on several mAb2 programmes (internal and collaboration projects).- Responsible for developability assessment, coordinating some activities with F-star characterisation team- CMC recommendation for mAb2 lead selection package

• Principal Research Associate

  • Mar 2017 - Aug 2018

  Responsible for protein production to support multiple discovery and pre-development projects. - Scheduling and delivery of proteins - Accountable for product quality- Internal and external stakeholders management- Line and matrix managementTechnical expert and team leader for expression technologies.Protein Sciences representative on mAb2 programmes.H&S deputy (performing monthly lab audits, writing and reviewing of COSHH)

• Senior Research Associate

  • Mar 2015 - Feb 2017

  Responsible for the protein expression lab: cell maintenance, scheduling of transfections, reagent and consumable stocks management, supervising junior team member. Optimisation of existing cell culture protocols and evaluation of new methods.Performed cloning of mAb2 (bispecific antibody).Supervision and mentoring of an intern in protein purification.Coordination of the work between USP and DSP teams.Protein Science representative on several discovery projects.

• Research Associate

  • Jan 2014 - Feb 2015

  Part of the Protein Science team, I was involved in the production of research scale recombinant proteins, towards in vitro and in vivo testing.Independently performing transient transfection, affinity purification and quality control (SEC-HPLC, SDS-PAGE, endotoxin testing) of Fcab (engineered antibody Fc fragments) and mAb2 (bispecific antibodies).



Lonza

• Switzerland
• Pharmaceutical Manufacturing
• 700 & Above Employee

• R&D Scientist

  • Aug 2010 - Jan 2014

  Worked on several research projects focusing on: - antibody engineering to reduce aggregation and improve expression - developing new mammalian host cell lines and new expression vector systems to enhance production of recombinant proteins Supervision and mentoring of summer placement student Display Screen Equipment/workstation risk assessor Worked on several research projects focusing on: - antibody engineering to reduce aggregation and improve expression - developing new mammalian host cell lines and new expression vector systems to enhance production of recombinant proteins Supervision and mentoring of summer placement student Display Screen Equipment/workstation risk assessor



Pierre Fabre Group

• France
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Intern

  • Sep 2007 - Feb 2008

  Internship at Centre d’Immunolgie Pierre Fabre (CIPF). Setting up and optimisation of two monoclonal antibodies transient expression in eukaryotic systems. Project included vectors construction, cell culture, analytics and immunoassay. Internship at Centre d’Immunolgie Pierre Fabre (CIPF). Setting up and optimisation of two monoclonal antibodies transient expression in eukaryotic systems. Project included vectors construction, cell culture, analytics and immunoassay.



CEREP

• Intern

  • Jun 2006 - Aug 2006

  Cloning by PCR of G/C rich and long gene Cloning by PCR of G/C rich and long gene