Matt Smola
Associate Director, RNA Biology at Ribometrix Inc.- Claim this Profile
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Bio
Experience
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Ribometrix Inc.
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United States
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Biotechnology Research
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1 - 100 Employee
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Associate Director, RNA Biology
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Feb 2022 - Present
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Senior Scientist I
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Jan 2020 - Jan 2022
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Scientist II
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Mar 2018 - Jan 2020
Raleigh-Durham, North Carolina Area
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Novartis Institutes for BioMedical Research (NIBR)
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United States
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Pharmaceutical Manufacturing
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700 & Above Employee
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Postdoctoral Scholar
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May 2016 - Feb 2018
Cambridge, MA As a Postdoctoral Scholar at NIBR, my work focused on technology and assay development. My contributions to various projects included the development of novel cell-based screening assays, adaptation of complex reporter systems, and purification of RNA-protein complexes for structural studies.
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University of North Carolina at Chapel Hill
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Research
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1 - 100 Employee
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Graduate Research Assistant
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Aug 2010 - May 2016
Chapel Hill, NC Structure-function studies of lncRNA, both in vitro and in living cells, using structure-selective chemical probes combined with massively parallel sequencing. - Used chemical probing data to develop and interpret structural models of lncRNA targets - Combined experimental and bioinformatic analysis to reveal new facets of lncRNA biology - Created a simple, rapid approach for accessing chemical probing data from low-abundance RNAs - Developed and validated a computational… Show more Structure-function studies of lncRNA, both in vitro and in living cells, using structure-selective chemical probes combined with massively parallel sequencing. - Used chemical probing data to develop and interpret structural models of lncRNA targets - Combined experimental and bioinformatic analysis to reveal new facets of lncRNA biology - Created a simple, rapid approach for accessing chemical probing data from low-abundance RNAs - Developed and validated a computational approach for identifying RNA-protein interaction sites - Successfully implemented new procedure to reduce sample prep time from 1 week to 1 day - Demonstrated that chemical probes can be applied to unnatural nucleic acids (XNAs) Show less
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Miami University
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Aug 2007 - May 2010
High-Field Magnetic Resonance Laboratory Crystallographic structure determination of a putative regulator of cyanobacterial heterocyst differentiation; NMR structure determination of an acyl carrier protein with details regarding post-translational modifications.
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Education
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University of North Carolina at Chapel Hill
Doctor of Philosophy (PhD), Chemical Biology -
Miami University
Bachelor of Science (BS), Biochemistry