Matt Smola

Associate Director, RNA Biology at Ribometrix Inc.
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Contact Information
Location
Durham, North Carolina, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Associate Director, RNA Biology
      • Feb 2022 - Present

    • Senior Scientist I
      • Jan 2020 - Jan 2022

    • Scientist II
      • Mar 2018 - Jan 2020

      Raleigh-Durham, North Carolina Area

    • United States
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • Postdoctoral Scholar
      • May 2016 - Feb 2018

      Cambridge, MA As a Postdoctoral Scholar at NIBR, my work focused on technology and assay development. My contributions to various projects included the development of novel cell-based screening assays, adaptation of complex reporter systems, and purification of RNA-protein complexes for structural studies.

    • Graduate Research Assistant
      • Aug 2010 - May 2016

      Chapel Hill, NC Structure-function studies of lncRNA, both in vitro and in living cells, using structure-selective chemical probes combined with massively parallel sequencing. - Used chemical probing data to develop and interpret structural models of lncRNA targets - Combined experimental and bioinformatic analysis to reveal new facets of lncRNA biology - Created a simple, rapid approach for accessing chemical probing data from low-abundance RNAs - Developed and validated a computational… Show more Structure-function studies of lncRNA, both in vitro and in living cells, using structure-selective chemical probes combined with massively parallel sequencing. - Used chemical probing data to develop and interpret structural models of lncRNA targets - Combined experimental and bioinformatic analysis to reveal new facets of lncRNA biology - Created a simple, rapid approach for accessing chemical probing data from low-abundance RNAs - Developed and validated a computational approach for identifying RNA-protein interaction sites - Successfully implemented new procedure to reduce sample prep time from 1 week to 1 day - Demonstrated that chemical probes can be applied to unnatural nucleic acids (XNAs) Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Aug 2007 - May 2010

      High-Field Magnetic Resonance Laboratory Crystallographic structure determination of a putative regulator of cyanobacterial heterocyst differentiation; NMR structure determination of an acyl carrier protein with details regarding post-translational modifications.

Education

  • University of North Carolina at Chapel Hill
    Doctor of Philosophy (PhD), Chemical Biology
    2010 - 2015
  • Miami University
    Bachelor of Science (BS), Biochemistry
    2006 - 2010

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