Experience

Lhasa Limited

• United Kingdom
• Software Development
• 100 - 200 Employee

• Senior Scientist

  • Dec 2001 - Present

  Develop knowledge based systems for the prediction of chemical toxicity and metabolism. Develop knowledge based systems for the prediction of chemical toxicity and metabolism.



HSE Health and Safety Laboratory

• Higher Scientific Officer

  • Mar 1992 - Nov 2001

  Development of structure-activity relationships for toxicity prediction (mainly skin sensitisation, respiratory sensitisation and to a lesser extent genotoxicity and mammalian toxicity endpoints). Review and development of skin absorption structure-property relationships including some quantitative modelling, e.g. of receptor fluid effects. Reviewed and published on the prediction of tissue-blood partition coefficients using octanol water partition coefficients and tissue composition (Payne MP and Kenny L. 2000). Actively contributed to the development of Lhasa Limited's Derek through a collaboration over several years, which also involved scientists from Unilever's research laboratory at Colworth Park Sharnbrook.



Health and Safety Executive

• United Kingdom
• Government Administration
• 700 & Above Employee

• Toxicologist

  • Jun 1989 - Mar 1992

  Toxicity reviews of industrial chemicals for submission to UK WATCH/ACTS exposure limit setting committees. Making critical scientific assessment of toxicity data packages submitted under the Notification of New Substances (NONS) regulations. I took the lead on the application of structure-activity relationships for predicting toxicity in a regulatory context, writing internal reviews on the subject and representing HSE at Lhasa Derek collaborative group meetings then held at the University of Leeds.