Experience

Evelo Biosciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Research Associate

  • Nov. 2017 - –Heute



ImmuneXcite

• Scientist I

  • Mai 2014 - –Heute

  • Conducted all aspects of In vivo efficacy experiments in mice in order to determine effectiveness of novel antibody conjugates on tumor activity in various xenograft models.• Performed all manner of tissue culture (maintenance, passaging, expanding lines, freeze runs) for a dozen xenograft models.• Implanted cells subcutaneously, dosed study conjugates, measured tumors with electronic calipers, tabulated, graphed and presented data to line manager, and presented data at meetings with CSO. • Responsible for performing Pharmacokinetic (PK) studies to determine antibody conjugate levels in plasma.• Surgically removed and fixed tumors for immunohistochemistry analysis.• Performed imaging of mice from various efficacy studies.• Supported chemistry department by performing SDS-PAGE analysis.



Ipsen Inc. (Biomeasure)

• Senior Research Associate

  • Dez. 1995 - Feb. 2014

  • In vivo RPTM (research project team member) for one of company’s high profile R&D projects.• Responsible for preparation and presentation of in vivo data at global bi-monthly project team meetings and monthly group meetings.• Responsible for the development of in vivo POC model in rats for current research project.• Presented in vivo project data at two GPR (global project review) meetings in France.• Responsible for the development of NET models in athymic nude mice in conjunction with new research focus.• Performing toxicological studies on newly synthesized compounds in order to determine the bioavailability in the body over time. • Conducted all aspects of over 500 in vivo experiments; involving the effects of various peptide proteins or other test compounds on human derived tumors in Athymic nude mice.• Responsible for designing studies, including proper compound dose, route and method of drug delivery.• Performed surgery including castrations on both mice and rats, canulations of the carotid artery in rats, implantation of mini-osmotic pumps in both rats and mice and maintained six tumor lines in rats.• Performed toxicology studies to ascertain viable compound dosage prior to extensive investigation in large groups of mice. • Injected human tumor cells sc in mice, randomized animals according to tumor size, administered various study compounds and vehicle groups, measured tumor size using calipers on a biweekly basis, analyzed and plotted data.• Proficient in many injection types including; ip, iv, sc and oral gavage administration of compounds. Also performed cardiac puncture in mice and drawn blood via the tail vein in rats to obtain blood samples for testing.• Performed tissue culture including starting cell lines from cryopreservation, day to day maintenance of cells, scaling up the number of flasks in preparation of implantation and performing freeze runs in order to maintain cell supply.



BASF Bioresearch Corporation

• Research Assistant: Immunology (Contract Position)

  • Jan. 1995 - Dez. 1995

  Conducted several in vivo experiments involving septic shock, Footpad and Airpouch models in mice. Scored extent of arthritis, administered ip injections, collected blood via retro-orbital plexus. Conducted ELISA experiments for the presence of Interleukin-1α and Interleukin-1β from mouse plasma. Conducted several in vivo experiments involving septic shock, Footpad and Airpouch models in mice. Scored extent of arthritis, administered ip injections, collected blood via retro-orbital plexus. Conducted ELISA experiments for the presence of Interleukin-1α and Interleukin-1β from mouse plasma.



Institute of Molecular Biology Inc.

• Research Associate (Soft Tissue Research)

  • Juli 1991 - Dez. 1994

  • Coordinated, scheduled and managed all aspects of many pre clinical in vivo research projects involving the effects of growth factors on soft tissue skin wounds.• Performed surgery, administered anesthesia, applied study medication, collected and analyzed data and wrote technical reports for over 20 pre clinical soft-tissue research projects.• Assisted in the surgical procedure for one study involving partial thickness wounds in swine.• Responsible for the formulation of the growth factors into delivery vehicle for over 70 independent research projects for the soft tissue, hard tissue and nerve research groups.• Developed and implemented syringe color coding system into formulation procedure to ensure the correct uses of formulated growth factor products.• Instructed and trained research personnel in the safe handling and use of radioisotopes.• Trained and supervised new personnel in the maintenance of 3T3 cell cultures of mouse fibroblast cells.