Mariya Chavarha

Senior Scientist, Computational Biology at Encodia
  • Claim this Profile
Contact Information
Location
Palo Alto, California, United States, US

Topline Score

Topline score feature will be out soon.

Bio

Generated by
Topline AI

You need to have a working account to view this content.
You need to have a working account to view this content.

Experience

    • Italy
    • Information Technology & Services
    • 1 - 100 Employee
    • Senior Scientist, Computational Biology
      • Apr 2022 - Present

      San Diego, California, United States Leading binder discovery using yeast display for a proprietary protein sequencing platform

    • Scientist II
      • Jun 2021 - Mar 2022

      San Diego, California, United States

    • United States
    • Software Development
    • 700 & Above Employee
    • Postdoctoral Researcher
      • May 2019 - May 2021

      Mountain View, CA Building custom molecular biology and biochemistry tools to accelerate AI- and ML- driven advances across biological disciplines. Data analytics and application of ML/AI models in a range of projects, from protein engineering to multi-omics data analysis to building image-based classifiers.

    • Research Scientist Consultant
      • Sep 2018 - Apr 2019

      Mountain View, CA

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate Student
      • Sep 2012 - Dec 2018

      Department of Bioengineering, protein engineering focus, Michael Lin lab. As a graduate student I developed fluorescent protein-based biosensors for imaging and optogenetic control of cellular processes. My thesis focused on improving genetically-encoded voltage indicators for imaging neuronal activity in the brain. For this interdisciplinary multi-team project I have: • Prototyped and validated a novel screening method for rapid… Show more Department of Bioengineering, protein engineering focus, Michael Lin lab. As a graduate student I developed fluorescent protein-based biosensors for imaging and optogenetic control of cellular processes. My thesis focused on improving genetically-encoded voltage indicators for imaging neuronal activity in the brain. For this interdisciplinary multi-team project I have: • Prototyped and validated a novel screening method for rapid development of genetically-encoded voltage sensors • Extended the approach to build a high-throughput automated screening system • Validated new methods for deterministic library construction and expression in mammalian cells • Screened over 2000 indicators in a span of 6 months. Previous sensors developed by testing at most 100 sensors/year by patch-clamping • Engineered a voltage indicator with 2-fold better detection of action potentials than predecessor • Further improved voltage indicators by restricting their subcellular expression to neuronal soma • The sensor enabled achievement of a critical milestone in the field - imaging neuronal activity in awake mice at single-cell single-trial level using two-photon microscopy Show less

    • Research Assistant II
      • Jul 2008 - Aug 2012

      Biophysics research in laboratory of Dr. Steve Hall. Studied the role of lung surfactant proteins in the activity of pulmonary surfactant through model lipid-protein systems and X-ray scattering.

    • United States
    • Higher Education
    • 700 & Above Employee
    • Undergraduate Research Assistant
      • Jun 2007 - Aug 2007

      John S. Rogers Summer Research Program / Neuromodulatory proteins Investigated cellular trafficking and localization of the neuromodulatory protein, plasminogen, in hippocampal neurons.

    • Undergraduate Research Assistant
      • Jun 2006 - Aug 2006

      John S. Rogers Summer Research Program / Molecular Modeling Computational chemistry research on elucidating rearrangement mechanism of an electrocyclic chemical reaction. Used Gaussian and Gaussview computer software to perform high-level computations, and used a novel way of molecular orbital analysis for discerning reaction mechanism.

Education

  • Stanford University
    Doctor of Philosophy (PhD), Bioengineering
    2012 - 2017
  • Lewis & Clark College
    Bachelor of Arts (BA), Chemistry
    2004 - 2008

Community

You need to have a working account to view this content. Click here to join now