Mariya Chavarha
Senior Scientist, Computational Biology at Encodia- Claim this Profile
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Bio
Experience
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Encodia
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Italy
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Information Technology & Services
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1 - 100 Employee
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Senior Scientist, Computational Biology
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Apr 2022 - Present
San Diego, California, United States Leading binder discovery using yeast display for a proprietary protein sequencing platform
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Scientist II
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Jun 2021 - Mar 2022
San Diego, California, United States
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Google
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United States
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Software Development
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700 & Above Employee
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Postdoctoral Researcher
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May 2019 - May 2021
Mountain View, CA Building custom molecular biology and biochemistry tools to accelerate AI- and ML- driven advances across biological disciplines. Data analytics and application of ML/AI models in a range of projects, from protein engineering to multi-omics data analysis to building image-based classifiers.
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Research Scientist Consultant
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Sep 2018 - Apr 2019
Mountain View, CA
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Stanford University
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United States
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Higher Education
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700 & Above Employee
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Graduate Student
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Sep 2012 - Dec 2018
Department of Bioengineering, protein engineering focus, Michael Lin lab. As a graduate student I developed fluorescent protein-based biosensors for imaging and optogenetic control of cellular processes. My thesis focused on improving genetically-encoded voltage indicators for imaging neuronal activity in the brain. For this interdisciplinary multi-team project I have: • Prototyped and validated a novel screening method for rapid… Show more Department of Bioengineering, protein engineering focus, Michael Lin lab. As a graduate student I developed fluorescent protein-based biosensors for imaging and optogenetic control of cellular processes. My thesis focused on improving genetically-encoded voltage indicators for imaging neuronal activity in the brain. For this interdisciplinary multi-team project I have: • Prototyped and validated a novel screening method for rapid development of genetically-encoded voltage sensors • Extended the approach to build a high-throughput automated screening system • Validated new methods for deterministic library construction and expression in mammalian cells • Screened over 2000 indicators in a span of 6 months. Previous sensors developed by testing at most 100 sensors/year by patch-clamping • Engineered a voltage indicator with 2-fold better detection of action potentials than predecessor • Further improved voltage indicators by restricting their subcellular expression to neuronal soma • The sensor enabled achievement of a critical milestone in the field - imaging neuronal activity in awake mice at single-cell single-trial level using two-photon microscopy Show less
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Research Assistant II
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Jul 2008 - Aug 2012
Biophysics research in laboratory of Dr. Steve Hall. Studied the role of lung surfactant proteins in the activity of pulmonary surfactant through model lipid-protein systems and X-ray scattering.
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Lewis & Clark College
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Jun 2007 - Aug 2007
John S. Rogers Summer Research Program / Neuromodulatory proteins Investigated cellular trafficking and localization of the neuromodulatory protein, plasminogen, in hippocampal neurons.
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Undergraduate Research Assistant
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Jun 2006 - Aug 2006
John S. Rogers Summer Research Program / Molecular Modeling Computational chemistry research on elucidating rearrangement mechanism of an electrocyclic chemical reaction. Used Gaussian and Gaussview computer software to perform high-level computations, and used a novel way of molecular orbital analysis for discerning reaction mechanism.
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Education
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Stanford University
Doctor of Philosophy (PhD), Bioengineering -
Lewis & Clark College
Bachelor of Arts (BA), Chemistry