Marilù Casini
PhD Student | Marie Skłodowska-Curie Fellowship at IIS La Fe - Medical Research Institute Hospital La Fe- Claim this Profile
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Italian Native or bilingual proficiency
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English Full professional proficiency
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Spanish Professional working proficiency
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Experience
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PhD Student | Marie Skłodowska-Curie Fellowship
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Oct 2020 - Present
PersonalizeAF Innovative Training Network (ITN), funded by the European Commission’s Horizon 2020 Marie Skłodowska-Curie programme. PersonalizeAF targets to deliver an innovative multinational, multi-sectorial, and multidisciplinary research and training programme in cardiac genetics, cardiac ion channels, stem cells, signal and image processing, computer modelling and patient management with the focus to investigate AF mechanisms with a translational-oriented approach, develop more effective therapies aiming at terminating the disease mechanisms, and finally personalize AF treatments. The aim of my personal project is to develop an in-vitro workbench for drug screening by developing a population of hiPSC-derived atrial cardiomyocytes that account for the interpatient variability in cardiac ion channels due to genetic/transcriptional factors. This population of models will be used for testing the arrhythmia inducibility after administration of drugs by analysing the electrophysiological behaviours and to determine patient biomarkers that can predict drug response and plan a personalized AF therapy. Show less
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Ncardia
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Netherlands
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Biotechnology Research
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1 - 100 Employee
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Visiting Research Fellow
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Jan 2023 - Mar 2023
The availability of iPSC-derived cardiomyocytes provides the opportunity to develop high-throughput compatible assays, allowing detection of changes in cardiac electrophysiology with a high sensitivity. During my period at Ncardia, I will develop the most optimal calcium transient assay to test cytokines effect on hiPSC-aCM and scale it up for high-throughput screening. The availability of iPSC-derived cardiomyocytes provides the opportunity to develop high-throughput compatible assays, allowing detection of changes in cardiac electrophysiology with a high sensitivity. During my period at Ncardia, I will develop the most optimal calcium transient assay to test cytokines effect on hiPSC-aCM and scale it up for high-throughput screening.
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University of Freiburg
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Germany
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Research
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300 - 400 Employee
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Visiting Research Fellow
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Mar 2022 - Jul 2022
The Cell Biophysics Group studies the signalling processes related to mechanical forces that are omnipresent and constantly changing in the heart. They shape life, acting either as crucial drivers for a wide range of physiological processes, or as potential threats to which cells have to adapt to survive in pathological conditions. How cells sense their environment and adapt their function to changes in mechanical states is the key question driving this group. Molecular mechanisms underlying this ability are poorly understood and we focus on mechano-sensitive channels, key players in Mechano-Electric Feedback (MEF). In this laboratory I will perform functional characterization of human induced pluripotent stem cells derived atrial and ventricular cardiomyocytes with patch clamp and optical mapping techniques. Co-culture of fibroblasts and hiPSC-CMs for atrial fibrillation in vitro model. Show less
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University Medical Center - Goettingen
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Germany
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Education Administration Programs
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1 - 100 Employee
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Intern
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Jan 2020 - Oct 2020
Awardee of ERASMUS+ scholarship for traineeship for an 9-months intern at the Institute of Pharmacology and Toxicology. Pathophysiological characterization of Noonan Disease using tissue-engineered heart models. Supervisors: Prof. Dr. Med. Wolfram Hubertus Zimmermann - Dr. Med. Malte Tiburcy Awardee of ERASMUS+ scholarship for traineeship for an 9-months intern at the Institute of Pharmacology and Toxicology. Pathophysiological characterization of Noonan Disease using tissue-engineered heart models. Supervisors: Prof. Dr. Med. Wolfram Hubertus Zimmermann - Dr. Med. Malte Tiburcy
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Scienza in Fabula
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Italy
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Primary and Secondary Education
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Tutor
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Nov 2019 - Jan 2020
Science tutor for kids - organization of creative and scientific laboratories for kids Science tutor for kids - organization of creative and scientific laboratories for kids
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Università degli Studi di Firenze
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Higher Education
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700 & Above Employee
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Senior Tutor
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Nov 2017 - Jan 2020
Promote an academic maturity in students assisting students in strengthening academic background, understanding class materials, comprehending the textbook, organizing assignments, and in improving general learning and study skills
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Student Representative
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Mar 2016 - Jan 2020
Listening, collating and communicating views of Medical University’s students. Neurofarba Department, Faculty Academic Standars and Quality Commitee member. Furthermore, my coworkers and I have organised Science Academic Conferences inviting Professors of great importance for research: • BioMedDay – stem cell in regenerative medicine (2017) • BioMedDay 2.0 – the future of medicine (2018) • BioMedDay 3.0 – science behind society and politics (2019)
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Education
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University of Florence
Master, Pharmaceutical Chemistry and Technologies