Senior Scientist - Lead In vivo Pharmacology

• Aug 2022 - Present

Scientist

• Aug 2021 - Present

Senior Postdoctoral Scientist

• Apr 2020 - Jul 2021

Researcher in the Lab for Molecular Cancer Biology of Prof. Dr. Jean-Christophe MarineIn collaboration with Flamingo Therapeutics, a newly created spin-off company, involved in the development of novel treatment options for various cancers, focusing on the non-coding genomeIn vivo pharmacology:- Planning, design, follow up and interpretation of in vivo cancer studies in rodent models (PDX and xenografts models). - Pharmacological treatment of rodents and tissue processing- Documentation, analysis and interpretation of experiments for the evaluation of pre-clinical candidates as potential therapeutic agents.- Coordination of CRO service providers (commercial entities and academic collaborators). - Data management, analysis and report

Postdoctoral Scientist

• Apr 2019 - Mar 2020

Researcher in the Laboratory of Tumor Inflammation and Angiogenesis of Prof Dr Massimiliano Mazzone.In collaboration with VIB-Discovery Science departmentEvaluation of metabolic targets involved in tumor immunosupression

Researcher - Postdoctoral Fellow

• Jan 2017 - Apr 2020

Using gold standard and emerging imaging technologies, I explored during the course of my PhD work the impact of different treatments on tumor metabolism in vivo. During this project, I clearly identified the limits of in vitro studies to reflect the in vivo context and highlighted the predominant role of local environment to shape tumor profile in vivo. Beyond the role of the physiological environment, the impact of host cell and the metabolic interplay between host cells and cancer cells represent a new field of research that I wanted to further investigate. Exploiting my knowledge in metabolic profiling obtained during my PhD, my research project was to assess the impact of immunotherapy on tumor metabolism using molecular imaging. I was also responsible for the in house implementation of hyperpolarization technology, the daily evaluation of the hyperpolarization system and the strategy development of the technology in various fields of research such as oncology, inflammation and neurology.

Researcher - PhD Fellow

• Oct 2016 - Jan 2017

PhD Student at Biomedical Magnetic Resonance Unit (REMA), Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL)Grant: "Bourse du Patrimoine pour la recherche médicale"During my PhD thesis, I worked on a multi-modality imaging project to characterize the tumor metabolism and its pharmacological modulations

Researcher - PhD fellow of the Belgian National Fund for Scientific Research (FNRS)

• Oct 2012 - Sep 2016

PhD Student at Biomedical Magnetic Resonance Unit (REMA), Louvain Drug Research Institute (LDRI), Université catholique de Louvain (UCL)During my PhD thesis, I worked on on a multi-modality imaging project to characterize the tumor metabolism and its pharmacological modulations.I designed a multi-modality imaging project to identify metabolic signature inside solid tumors based on metabolic modulations. Various technologies, including PET, MRI, MRS and EPR, were used to study the impact of Dichloroacetate treatment and hypoxia in tumor models presenting different metabolic profiles. The current study established a metabolic discrepancy between in vitro and in vivo conditions. While tumor cell lines presented distinct behaviors according to their metabolic profiles, the tumors models presented similar metabolic patterns in vivo. The absence of true correlation between in vitro and in vivo tumor models suggested the key role of local microenvironment and host cells to shape tumor features.

NIH Special Volunteer

• Oct 2015 - Mar 2016

During this 6 month stay at the NIH, I specialized myself in innovative imaging technologies, including Electron Paramagnetic Resonance (EPR) for oxygenation imaging and Hyperpolarization (DNP) for metabolic imaging. During this 6 month stay at the NIH, I specialized myself in innovative imaging technologies, including Electron Paramagnetic Resonance (EPR) for oxygenation imaging and Hyperpolarization (DNP) for metabolic imaging.

Pharmacist

• Jul 2012 - Sep 2012

Pharmacist student job Pharmacist student job

Pharmacy Internship

• Nov 2011 - May 2012

Training period in Pharmacy during Master’s degree program (6 month period) Training period in Pharmacy during Master’s degree program (6 month period)

Student Researcher

• Oct 2010 - May 2012

Student-researcher during Master’s degree program at Biomedical Magnetic Resonance Unit - REMA lab Directed by Prof B. Gallez and Co-Directed by Prof. B. Jordan Master thesis topic: “The potential value evaluation of Dynamic Contrast-Enhanced MRI (DCE-MRI) and Diffusion Imaging (DWI) to reflect cell death induced by a vascular targeting agent, the Combretastatin A4”. Student-researcher during Master’s degree program at Biomedical Magnetic Resonance Unit - REMA lab Directed by Prof B. Gallez and Co-Directed by Prof. B. Jordan Master thesis topic: “The potential value evaluation of Dynamic Contrast-Enhanced MRI (DCE-MRI) and Diffusion Imaging (DWI) to reflect cell death induced by a vascular targeting agent, the Combretastatin A4”.

Pharmacy Assistant

• Aug 2011 - Aug 2011

Student Job - Stock management Student Job - Stock management