Experience

Tigem

• Research Services
• 100 - 200 Employee

• PHD in Human Genetics

  • Jan 2010 - May 2014

  I performed the Open University doctoral study at TIGEM, in Naples. I was involved in a project concerning Tbx1 and Vegfr3 interaction in lymphangiogenesis and angiogenesis. Tbx1 is a transcription factor involved in the pathogenesis of DiGeorge syndrome. Previous studies showed that Vegfr3 is a direct Tbx1 target. I generated a Cre-inducible Vegfr3 transgenic mouse line that I used for in vivo rescue experiments. I performed the Open University doctoral study at TIGEM, in Naples. I was involved in a project concerning Tbx1 and Vegfr3 interaction in lymphangiogenesis and angiogenesis. Tbx1 is a transcription factor involved in the pathogenesis of DiGeorge syndrome. Previous studies showed that Vegfr3 is a direct Tbx1 target. I generated a Cre-inducible Vegfr3 transgenic mouse line that I used for in vivo rescue experiments.



Ospedale Casa Sollievo della Sofferenza

• Religious Institutions
• 500 - 600 Employee

• Biologist

  • Dec 2008 - Dec 2009

  I worked in the Medical Genetics Unit of IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo. I had been involved in two projects: • study of TRIM8 involvement in the glioblastoma development, • management of “Genomic Disorders Bank”, consisting of DNA, RNA and cell lines collection from individuals affected by Williams−Beuren syndrome and other genomic disorders.

• Internship - Second Level Degree

  • Dec 2007 - Nov 2008

  Relatively to the second level degree, my thesis was about SVAS an obstructive vascular disease. We identified six novel mutations in the ELN gene (SVAS) and performed functional analysis of three of them. We founded that two were responsive to the NMD (nonsense mediated decay), while the other induced an alteration of correct splicing.



Ospedale Casa Sollievo della Sofferenza

• Religious Institutions
• 500 - 600 Employee

• Internship - First Level Degree

  • Jan 2006 - May 2006

  Relatively to the first level degree, my thesis was about inflammation indexes, in particular about correlations between the high value of VES and IgG, IgM and C3 in a lot of patients affected by different diseases. Relatively to the first level degree, my thesis was about inflammation indexes, in particular about correlations between the high value of VES and IgG, IgM and C3 in a lot of patients affected by different diseases.