Maria del Carmen Lopez Ruiz

Senior Editor at Spandidos Publications
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Contact Information
us****@****om
(386) 825-5501
Location
UK
Languages
  • Spanish Native or bilingual proficiency
  • English Full professional proficiency
  • Catalan Professional working proficiency
  • French Elementary proficiency
  • Portuguese Elementary proficiency
Skills

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Credentials

  • Commercial French Course
    Instituto Nacional de Empleo
  • First Certificate in English
    University of Cambridge
  • French Course
    SEGRO plc
  • Marketing English Course
    Instituto Nacional de Empleo
  • Valencià Grau Mitjà
    Junta Qualificadora d´Exàmens de Valencia

Experience

  • Spandidos Publications
    • Greece
    • Book and Periodical Publishing
    • 1 - 100 Employee
    • Senior Editor
      • Dec 2016 - Present

      Evaluation of peer-reviewed articles, ethics compliance (ethical guidelines, ethics approval, patient informed consent, methods of anesthesia and euthanasia of laboratory animals), cell line identification (ICLAC, Cellosaurus Expasy), management of editorial meetings, editorial policies, journal metrics (CiteScore, Impact factor), development of in-house processes/guidelines/company organigramManuscript editing - Language editing (grammar, style, scientific content), edition of figures and tables (Word, InDesign, Photoshop), research integrity (methodology, controls, assessment of potential fraud, plagiarism, figure and data manipulation)Conferences:- Spandidos Publications representative (ALPSP Conference, September 2016, Heathrow, UK)- Spandidos Publications representative (23rd World Congress on Advances in Oncology and 22nd International Symposium on Molecular Medicine, September 2018, Athens, Greece)

    • Scientific Editor
      • May 2015 - Dec 2016

      Copy-editing and proof-reading scientific manuscripts (Oncology Letters journal), assessment of peer-review process, evaluation and selection of peer-reviewers, evaluation of junior editors, liaison with authors (queries, cleans), elaboration of scientific tests for potential new employees, assessment of plagiarism, ethics, cell line contamination and references accuracy, conference attendance, editorial meetings, presentations, business recommendations, evaluation of first and independent readers at Spandidos Publications and correction of their work Editorial software: InDesign (MAC), Word, Photoshop, Edifix, iThenticate

  • BMC
    • United Kingdom
    • Book and Periodical Publishing
    • 100 - 200 Employee
    • Assistant Editor
      • Mar 2015 - May 2015

      Peer-review referee selection, manuscript handling, submission checks, acceptance/rejection decision making, associate editor assignment Peer-review referee selection, manuscript handling, submission checks, acceptance/rejection decision making, associate editor assignment

  • Oxitec
    • United Kingdom
    • Biotechnology Research
    • 100 - 200 Employee
    • Molecular Biologist - Proteins
      • Jan 2015 - Mar 2015

      Recombinant protein expression in E.coli, IMAC purification, SDS-PAGE, Western blotting (colorimetric and ECL development), BCA assay Recombinant protein expression in E.coli, IMAC purification, SDS-PAGE, Western blotting (colorimetric and ECL development), BCA assay

  • UCB
    • Belgium
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • Research Scientist Protein Biochemistry & Biophysics
      • Aug 2012 - Oct 2014

      Department: UCB New Medicines - Discovery Research & Antibody BiophysicsTechniques: - Circular Dichroism: Protein secondary and tertiary structure, unfolding and thermostability (temperature ramp), pH-dependent conformational changes, novel antibody formats (fragments, bi/trispecifics), fibril amyloid formation, mutations- Micro Scale Thermophoresis: Study of molecular interactions (protein-protein, antibody-target, protein-peptide, protein-drug, drug-serum off-target interactions, antibody self-interaction) and affinity determination- Differential Scanning Fluorimetry: Measurement of Tm, redox and pH dependent protein thermostability, protein-ligand binding assessment- Dynamic Light Scattering: Protein particles identification and size quantification, detection of aggregate formation during antibody purification- HPLC: Estimation of protein size, monodispersity, sample purity, protein complex formation and binding reactions via analytical Size Exclusion Chromatography (SEC)- Visible and UV Absorption Spectroscopy: Protein quantification (A280 and BCA assay), protein aggregation and colloidal stability (OD600), thiol titration (A324), off-target interactions (Self-Interaction Nanoparticle Spectroscopy), quantification of bacterial and yeast cell growth (OD600)- SDS-PAGE (Coomassie and Red Ponceau staining): Assessment of protein purity, protein degradation during stability stress studies, confirmation of antibody fragmentation or deglycosylation upon enzymatic reaction, separation of immunoglobulin heavy and light chains under reducing versus oxidizing conditions- Fluorescence Spectroscopy: Intrinsic (protein denaturation in the presence of chaotropic agents) and extrinsic (fluorescence protein labelling via amine or cysteine coupling) fluorescence- Crystallography: Robotic handling and preparation of plate screening conditions for antibody-target complex co-crystallization, sitting-drop initial crystal trials, hanging-drop crystal optimization

    • Communications - Conferences, meetings, posters and presentations
      • Aug 2012 - Oct 2014

      • “Structural characterization of proteins by Circular Dichroism” (Poster, UCB Congress, October 2014, Slough, UK)• “Purification-characterisation of heavy chain antibody dimers” (Poster, UCB Congress, October 2014, Slough, UK)• “Fluorescence applications: MST” (Oral presentation, Internal Seminar UCB, January 2014, Slough, UK)• “Antibody biophysics: CD Applications:” (Oral presentation, Internal Seminar UCB, July 2014, Slough, UK)• “Investigating the binding of micromolar affinity antibodies” (Poster, Science Day UCB, December 2013, Slough, UK)Prizes (2): Highest scientific merit (as awarded by Discovery Biology Leadership Team at UCB and conference attendees)• “CD applications: antibody structure and formulation” (VRDE Journal Club UCB, May 2013, Slough, UK)• “Microscale Thermophoresis to study molecular interactions”(Poster, Science Advisory Board Meeting, March 2013, Slough, UK)• “Microscale Thermophoresis to study molecular interactions” (Poster, Science Day UCB, December 2012, Slough, UK) • “A day in the life of Mari Lopez” (Editorial Interview Pharmaphorum, UCB, October 2012, Slough, UK)

  • UCB, Imperial College London, IST and University of Leeds
    • Courses
      • Jun 2006 - Oct 2014

      Science: • Molecular Operating Environment (MOE) Training • SEC-MALS Training • HPLC - Big Molecules, Big Challenges • Basic Concepts of HPLC • Column Care and Maintenance • HPLC Instrument Basics and Troubleshooting • Immunology Course • Introduction to Drug-Receptor Interactions Mini-Internship • Circular Dichroism • Inhalation Therapy • Non Clinical Development Internship: Safety Evaluation & DMPK • ITC 200 Microcalorimetry • Cell Disruptor Training • Infrared and X-ray Technology Showcase • Membrane Purification Symposium • Current Trends in Membrane Proteins • Modern Laser Microscopy • Radioactive Training • Bioinformatics of Membrane Proteins • SPR Biacore 3000 Training • Genetic Modified Organisms • Movement of Transbilayer Lipids • Membrane Proteins: from the gene to the test tube • Fluorescence and ESR in Membrane Research • International Summer School on Biophysics Communication: • Pronunciation for Non-English Speakers • Word for Large Documents • Writing up your Research for Publication • Effective Poster and Conference Presentations Compliance: • Copyright Awareness • Use of Patentsafe • Intellectual Property Mini-Internship • UCB Employee Safety Reporting Obligations • IDBS E-Workbook • IT Security Awareness • SAP Kernel - SRM – eProcurement • e-Signature Policy UCB • Data Recording - Research Guidance • Display Screen Equipment Workstation Training & Assessment Professional Development: • Franklin Covey Extraordinary Productivity • Introduction to Herman Braine Model • Personal Resilience &Stress Management Workshop • Personal Impact & Networking with Confidence • Springboard Women’s Development • Launching your Career • Mini-MBA: Translation of Science into Business Health and Safety: • Workplace Safety • Powder Weigh Hood • Laboratory Spill Kit • COSHH Laboratory Safety • Manual Handling • Fire Evacuation Awareness • Working with Sharps • HTA Awareness

  • Imperial College London
    • Research Services
    • 700 & Above Employee
    • Post-doctoral Research Associate
      • Oct 2010 - Aug 2012

      Techniques: - Molecular Biology: PCR, Cloning, DNA purification, Sequencing, Restriction digestion, Ligation, Transformation, DNA Electrophoresis. - Biochemistry: Large-scale recombinant expression of GFP-tagged membrane proteins in E.coli, Cell disruption, Membrane isolation via ultracentrifugation, Membrane protein extraction with detergents, Protein purification by affinity chromatography (Ni-NTA) and size-exclusion chromatography (AKTA), Protein quantification by BCA, UV Absorbance and Fluorescence, SDS-PAGE, In-gel fluorescence and Coomassie staining, Liposomes preparation, Protein reconstitution in synthetic lipid vesicles, In-vivo (whole cells) and in-vitro (proteoliposomes) fluorescence ligand uptake assay. - Biophysics: Visible and UV Absorption Spectroscopy, Synchrothron Radiation Circular Dichroism (SRCD), Fluorescence anisotropy, Isothermal Calorimetry (ITC), SEC-MALS, X-Ray Crystallography and Electron Microscopy (Single particle analysis, CryoEM and 2D crystals preparation). - Membrane Protein Crystallography: Automated (Mosquito) and manual (hanging drop) crystallization techniques. MemGold, MemStart, secondary detergent and additive crystallization screens. Handle and storage of crystals. X-ray crystal diffraction and initial data collection. Conferences and presentations at meetings: • “Structural and functional characterization of the membrane antibiotic transporter SbmA” (Poster, Progress and challenges in bacteriocin research Conference, The Biochemical Society, July 2012, University of Nottingham, Nottingham, UK) • “Structural and functional characterization of the membrane antibiotic transporter SbmA” (Oral presentation, Membrane Protein Laboratory Meeting, July 2012, Diamond Light Source, Didcot, UK) • “Bacterial antibiotic transporters” (Oral presentation, Macromolecular Crystallography Seminar, November 2011, Research Complex at Harwell Campus, Didcot, UK)

  • University of Leeds & Instituto Superior Tecnico Lisboa
    • Marie Curie Fellowship PhD
      • Jun 2006 - Jul 2010

      Techniques: - Molecular Biology: PCR, Cloning, DNA purification, Sequencing, Restriction digestion, Ligation, Transformation, Electrophoresis, Site-directed mutagenesis. - Biochemistry: Recombinant protein expression in bacteria (E. coli), yeast (Pichia pastoris), insect cells (Drosophila Schneider S2) and in-vitro cell-free systems, Protein purification by affinity chromatography (Ni-NTA and Glutathione Sepharose), Protein quantification by BCA and spectrophotometry, SDS-PAGE, Western Blot, Protein-protein and protein-ligand binding assays. - Tissue Culture: Growth and maintenance of insect cell cultures, Stable and transient transfection. - Biophysics: Visible and UV Absorption Spectroscopy, Fluorescence (FRET, Protein derivatization, Steady-state and time-resolved anisotropy, Time-resolved fluorescence, FCS, Confocal microscopy), 3H Radioactivity, Mass Spectrometry (Peptide Mass Fingerprinting MALDI-TOF).

  • Instituto Superior Técnico, University of Leeds and Marie Curie Fellowship European Union PhD
    • PhD Communications, posters, presentations, conferences:
      • Jun 2006 - Jun 2010

      • “RBP Receptor - Structure and Function” (Doctoral thesis manuscript and oral presentation, PhD Viva, July 2011, Instituto Superior Tecnico, Lisbon, Portugal) • “RBP Receptor - Structure and Function” (Oral presentation, Membrane Systems Biology Meeting, October 2009, University of Leeds, Leeds, UK) • “RBP Receptor - Structure and Function” (Oral presentation and written report, Final Annual Assembly of the Consortium Marie Curie program for Early Stage Training in Membrane Biology, September 2009, Rovinj, Croatia) • “RBP Receptor - Structure and Function” (Oral presentation, Marie Curie Laboratory for Membrane Proteins, National University of Ireland, February 2009, Maynooth, Ireland) • “RBP Receptor - Structure and Function” (Oral presentation and written report, Third Annual Assembly of the Consortium Marie Curie program for Early Stage Training in Membrane Biology, Universidad Complutense de Madrid, October 2008, Madrid, Spain) • “RBP Receptor - Structure and Function” (Oral presentation, Postgraduate Symposium Leeds Institute of Genetics, Health and Therapeutics, Faculty of Biological Sciences, University of Leeds, June 2008, Leeds, UK) • “RBP Receptor - Structure and Function” (Oral presentation and written report, Second Annual Assembly of the Consortium Marie Curie program for Early Stage Training in Membrane Biology, University of Berlin, September 2007, Berlin, Germany) • “RBP Receptor - Structure and Function” (Oral presentation, First Annual Assembly of the Consortium Marie Curie program for Early Stage Training in Membrane Biology, University of Utrecht, June 2006, Utrecht, The Netherlands)

Education

  • Instituto Superior Técnico
    Doctor of Philosophy - PhD, Biochemistry, Biophysics and Molecular Biology
    2010 - 2011
  • University of Leeds
    PhD Biochemistry (Marie Curie Fellowship), BsC Biochemistry (Erasmus student), Biochemistry, Biophysics and Molecular Biology
    2006 - 2010
  • University of Valencia
    BSc Biochemistry
    2004 - 2006
  • University of Valencia
    BSc Chemistry
    1998 - 2003

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