SHE Manager Chemical Operations

• Oct 2022 - Present

Owner at Chemistry4Fun

• Oct 2010 - Present

Chemistry4Fun is a company that contributes to popularization of chemistry by bringing the fascination and charm of this science under the attention of children and grownups. Chemistry4Fun offers a chemistry oriented theme for social activities of companies or the private sector and an educational program for schools, daycare, and "professor parties" for birthdays. For more information look at www.chemistry4fun.nl Ben jij bijna jarig en wil je je vriendjes en vriendinnetjes een knal feest geven? Vraag dan je ouders of ze een Professor feestje organiseren. Jullie woonkamer wordt omgetoverd in een echt laboratorium waarin jullie zelf aan de slag gaan met leuke en spannende proefjes. Net als in een echt laboratorium krijgen jullie een labjas aan en een veiligheidsbril op. Zo gaan jullie onderzoeken je zelf een lava-lamp kunnen maken, een onzichtbare brandblusser; van kleur veranderende heksenbrouwsels en natuurlijk echt chemistry4fun slime !!!!!! Na afloop krijgen jullie een diploma en proef-beschrijvingen mee naar huis. Zodat je ook thuis je ouders kunt laten zien wat jullie geleerd hebben. Wij verhuren alle materialen (labjassen; brillen; laboratorium benodigdheden; etc) inclusief een draaiboek waarin alle proeven duidelijk in staan uitgelegd. Met deze materialen en het draaiboek is het voor ouders eenvoudig om zelf een kinderchemie workshop te organiseren. Het feestje kan heel goed gegeven worden in een huiskamer, keuken of garage. Indien het buiten lekker weer is dan kan het feestje ook goed buiten georganiseerd worden. Het feestje duurt ongeveer 2 uur. Het professor feestje van Chemistry4Kids is een uitdagend en leerzaam kinderfeestje dat de jarige en zijn vriendjes/vriendinnetjes niet snel zullen vergeten. Al vele ouders hebben op deze manier voor hun kinderen een geslaagd kinderfeestje gegeven. Chemistry4Kids voor een uniek, leerzaam kinderfeestje. Voor meer informatie zie: www.chemistry4kids.nl Show less

Process Safety Manager

• Aug 2017 - Mar 2023

Compliance Engineer

• Oct 2013 - Jul 2017

Root cause analyses of incidents and unsafely situations within the departmentResponsible for processes in terms of occupational health, safety and environmental aspects Carry out (safety) studies such as HAZOPs’, LOPAs; RIE, FMECAMonitors the EHS performance of the department and ensures continuous improvement by presenting and detailing proposals for improvementExecute EHS-training within the department and monitors the EHS-KPI’s

Compliance Engineer

• Mar 2013 - Oct 2013

Root cause analyses of incidents and unsafely situations within the production departmentResponsible for processes in terms of occupational health, safety and environmental aspects Carry out (safety) studies such as HAZOPs’, RIE, FMECAMonitors the EHS performance of the department and ensures continuous improvement by presenting and detailing proposals for improvementExecute EHS-training within the department and monitors the EHS-KPI’s

Senior improvement Engineer, Chemical Operations

• May 2011 - Mar 2013

Initiate and enable improvements by data-analyses and the use of continuous improvement tools (e.g. Lean/six sigma; compliance, financial, robustness, standardized work) to drive out variation and to obtain a more robust; reproducible; efficient and less expensive production method. Maintain manufacturing process related documents (e.g. process risk inventarisation and batch records) up-to-date and compliant to GMP & HSE requirements.

Senior Process Development Chemist/Team leader, Department of Process Chemistry.

• Feb 2004 - May 2011

Team leader of 5 employees with BSc education in chemistry. Keeping performance and coaching session. Contribute to the process development and improvement of several drug development projectsDevelopment and implementation of new, safe and efficient synthesis routes for the production of heterocyclic API’s (up to multi-kg scale). Responsible for on time delivery of projects.Development of new synthesis routes for impurities, degradation products and of metabolites.Presentation of project results at international inter-departmental meetings.Good understanding of HSE as well as hazardous chemistry and knowledge how to perform organic synthesis in a safe and environmentally acceptable manner in laboratory and (pilot)-plantExperience in salt and polymorph selection studies.Member of interdisciplinary project teams for the early development of new drugs.Development and application of continuous flow technology on kg scaleResponsible for adequate transfer of production methods and know-how from development lab to subsequently kilolab, pilot plant and production under cGMP.Responsible for recruiting, training, coaching, and developing people. Show less

Process Development Chemist, Department of Process Chemistry.

• Dec 2000 - Jan 2004

Exploring new safe and efficient synthesis routes for the production of heterocyclic APIs (multi-kg scale). Synthesis of heterocyclic compounds (grams to kilogram scale) in order to support of the pre-and clinical research. Involved in the transfer of development routes to different (pilot)-plants for production under cGMP.Synthesis of impurities, degradation products and of metabolites. Experience with high throughput experimentation (HTE). Carrying out a literature review. Training and development of employees and trainees with BSc and MSc education in chemistry. Identify, purchase and implement new laboratory equipment, contact person for the purchasing department and sales representatives. Show less

Organic researcher, Department of Medicinal Chemistry

• Aug 1997 - Nov 2000

Responsible for the synthesis and analyses of new chemical entities; mainly steroids on milli to multi-gram scale. These were synthesized using conventional synthesis techniques as well as microwave chemistry, parallel synthesis and solid phase techniques. Product purification was done using flash chromatography, preparative HPLC, crystallization and distillation. Reaction monitoring and structure confirmation using analytical techniques such as TLC, MS, LC-MS, UPLC(-MS), 1H and 13C NMR, IR and GC(-MS). Supervisor of new employeesWrite reports and present results during meetings. Show less