Experience

Vedere Bio II

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist, Ophthalmology Research and Histology

  • Oct 2022 - Apr 2023

  Cambridge, Massachusetts, United States 1. Tissue Processing and Histology Platform Establishment: • Led and successfully implemented internal initiatives to establish a state-of-the-art tissue processing and histology platform. • Conducted standard histology procedures with precision and accuracy, ensuring high-quality sample preparation. 2. Assay Development for Discovery Efforts: • Developed innovative tissue and cell-based assays to support ongoing discovery efforts, contributing to the advancement of research… Show more 1. Tissue Processing and Histology Platform Establishment: • Led and successfully implemented internal initiatives to establish a state-of-the-art tissue processing and histology platform. • Conducted standard histology procedures with precision and accuracy, ensuring high-quality sample preparation. 2. Assay Development for Discovery Efforts: • Developed innovative tissue and cell-based assays to support ongoing discovery efforts, contributing to the advancement of research objectives. 3. In Vivo Team Support and AAV Expertise: • Provided valuable support to the in vivo team by actively participating in multiple tasks, including efficient AAV delivery and successful transgene expression. 4. Collaboration with External Partners: • Collaborated effectively with external collaborators, leveraging their expertise and establishing fruitful scientific partnerships. 5. Protocol Optimization, Data Analysis, and Reporting: • Optimized experimental protocols to enhance efficiency and ensure reliable and reproducible results. • Conducted thorough data analysis, extracting meaningful insights to drive research outcomes. • Authored comprehensive study reports and effectively presented findings at internal meetings, contributing to scientific discussions and knowledge sharing. 6. Research Compliance and Laboratory Management: • Adhered to rigorous Institutional Animal Care and Use Committee (IACUC) protocols, upholding ethical standards in research practices. • Demonstrated meticulousness in maintaining and updating an accurate and comprehensive electronic laboratory notebook (Benchling), ensuring data integrity and accessibility. Show less



Vanderbilt University Medical Center

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Staff Scientist

  • Mar 2020 - Jun 2022

  Nashville, TN, United States 1. ECM Repair in Glaucoma, Age-Related Macular Degeneration and CNS Injury: • Designed and executed in vitro and in vivo preclinical experiments to investigate the therapeutic potential of collagen mimetic peptides in repairing the damaged collagen in CNS injury, glaucoma, and in age-related macular degeneration. 2. Investigation of Extracellular Vesicles Role in Neurodegeneration: • Designed and executed in vitro and in vivo preclinical experiments, including in mice and in… Show more 1. ECM Repair in Glaucoma, Age-Related Macular Degeneration and CNS Injury: • Designed and executed in vitro and in vivo preclinical experiments to investigate the therapeutic potential of collagen mimetic peptides in repairing the damaged collagen in CNS injury, glaucoma, and in age-related macular degeneration. 2. Investigation of Extracellular Vesicles Role in Neurodegeneration: • Designed and executed in vitro and in vivo preclinical experiments, including in mice and in hESC-derived neurons, to explore the importance of intercellular communications via extracellular vesicles in neuronal survival and axon degeneration. 3. Collaborative Experimentation with Internal and External Partners: • Engaged in discussions and collaborated with internal and external collaborators, including a clinical stage biopharmaceutical company, to design and conduct a variety of in vitro and in vivo experiments. • Demonstrated effective collaboration and contributed to successful research outcomes. 4. Contribution to In-House AAV Viral Core Formation: • Played a vital role in the establishment of the newly created in-house AAV viral core, facilitating research operations and enabling efficient AAV-based studies. 5. Reporting and Communication: • Regularly reported research findings to colleagues and supervisor, fostering a collaborative and knowledge-sharing environment. • Mentored graduate students, PhD candidates, and postdoctoral fellows, providing guidance and support in their research endeavors. 6. Data Analysis and Manuscript Publication: • Conducted comprehensive data analysis, extracting meaningful insights and contributing to scientific discoveries. • Authored and published multiple scientific manuscripts, disseminating research findings to the scientific community. 7. Presentation and Scientific Meetings: • Elaborated on research findings and methodologies, presenting data at research meetings to facilitate scientific discussions and enhance knowledge exchange. Show less



University of Miami, Miller School of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Associate and Assistant Scientist

  • Sep 2014 - Jan 2020

  Miami, Florida, United States 1. In Vivo Surgeries in CNS Injury Models: • Proficiently performed rodent in vivo surgeries in models involving the retina and/or optic nerve, contributing to the understanding of CNS injury. 2. Discovery of Cellular Mechanism for CNTF-Induced Axon Regeneration: • Made a significant discovery by identifying a novel cellular mechanism responsible for axon regeneration induced by CNTF. 3. Role of Astrocytes and Neural Cadherin in RGC Axon Regeneration: • Investigated the pivotal… Show more 1. In Vivo Surgeries in CNS Injury Models: • Proficiently performed rodent in vivo surgeries in models involving the retina and/or optic nerve, contributing to the understanding of CNS injury. 2. Discovery of Cellular Mechanism for CNTF-Induced Axon Regeneration: • Made a significant discovery by identifying a novel cellular mechanism responsible for axon regeneration induced by CNTF. 3. Role of Astrocytes and Neural Cadherin in RGC Axon Regeneration: • Investigated the pivotal role of astrocytes and neural cadherin in the regeneration of RGC axons following optic nerve crush injury. 4. Protocol Optimization and Molecular Analysis: • Optimized protocols for in situ mRNA expression and localization in the retina and optic nerve, enabling precise examination and quantification of gene expression patterns. • Developed a novel method for isolating and purifying adult optic nerve mouse astrocytes using FACS for RNA sequencing, enhancing research capabilities in transcriptomic studies. • Conducted confocal imaging, data analysis, and quantification to extract meaningful insights from molecular analysis. 5. Primary Neuronal and Glial Cell Cultures: • Expertly performed primary neuronal and glial cell cultures, providing valuable experimental models for studying neural cell biology and interactions. 6. Training and Supervision: • Mentored and supervised students, providing guidance and fostering their development in scientific research. 7. Collaboration and Project Management: • Collaborated effectively with co-workers and external collaborators on multiple projects, including coordination with Contract Research Organizations. • Planned and designed research strategies, leveraging collective expertise to achieve project goals. 8. Data Analysis, Reporting, and Dissemination: • Analyzed data and reported findings to colleagues and supervisors, and in external conferences, and peer-reviewed manuscripts, contributing to the scientific community's knowledge base. Show less



Center for Neuroscience and Cell Biology

• Portugal
• Research Services
• 100 - 200 Employee

• PhD Student

  • Jan 2007 - Jul 2014

  University of Coimbra, Portugal 1. Identification of Novel Targets for Therapeutic Interventions in Early Models of Huntington's Disease (HD): • Successfully discovered novel cellular and molecular targets for potential therapeutic interventions in early models of HD, contributing to the development of treatment strategies for this debilitating neurodegenerative disorder. 2. Therapeutic Role of Insulin and IGF-1 against mHtt Effects: • Made a significant discovery by identifying a previously unknown therapeutic role… Show more 1. Identification of Novel Targets for Therapeutic Interventions in Early Models of Huntington's Disease (HD): • Successfully discovered novel cellular and molecular targets for potential therapeutic interventions in early models of HD, contributing to the development of treatment strategies for this debilitating neurodegenerative disorder. 2. Therapeutic Role of Insulin and IGF-1 against mHtt Effects: • Made a significant discovery by identifying a previously unknown therapeutic role of insulin and insulin-like growth factor 1 (IGF-1) in mitigating the deleterious effects of mutant huntingtin protein (mHtt), providing insights into potential therapeutic avenues for HD. 3. Planning, Optimization, and Execution of Biochemical Assays: • Developed and optimized protocols for various in vitro biochemical assays, ensuring accurate and reliable measurement of key molecular processes. • Conducted meticulous experimentation, generating valuable data for further analysis and interpretation. 4. Collaboration on Scientific Projects: • Collaborated effectively with colleagues on multiple scientific projects, including research in the field of Alzheimer's disease and Parkinson's disease. • Engaged in fruitful scientific discussions and knowledge-sharing, fostering a collaborative research environment. 5. Data Analysis and Findings Reporting: • Performed comprehensive data analysis, extracting meaningful insights and identifying significant trends and patterns. • Effectively communicated research findings through conference presentations and peer-reviewed publications, disseminating knowledge and contributing to the scientific community's understanding of HD and related neurodegenerative diseases. Show less



ECBio, S.A.

• Peru
• Hospitals and Health Care

• Curricular internship

  • Sep 2004 - Sep 2005

  Oeiras, Lisbon, Portugal 1. Screening of Natural Compounds for Potential Anti-Cancer Activity: • Conducted screening of natural compounds with potential anti-cancer activity using Chinese Hamster Ovary (CHO) cell lines and HCT-116 colon cancer cell lines. • Performed cell death/viability assays to assess the effectiveness of the compounds in inhibiting cancer cell growth. 2. Data Analysis and Presentation: • Analyzed the obtained data, interpreting the results and drawing meaningful… Show more 1. Screening of Natural Compounds for Potential Anti-Cancer Activity: • Conducted screening of natural compounds with potential anti-cancer activity using Chinese Hamster Ovary (CHO) cell lines and HCT-116 colon cancer cell lines. • Performed cell death/viability assays to assess the effectiveness of the compounds in inhibiting cancer cell growth. 2. Data Analysis and Presentation: • Analyzed the obtained data, interpreting the results and drawing meaningful conclusions. • Presented research findings at internal meetings, effectively communicating the outcomes of the screening experiments. 3. Scientific Graduation Thesis: • Authored a scientific graduation thesis, documenting the research process, methodology, results, and conclusions. • Demonstrated strong scientific writing skills in presenting the research in a structured and comprehensive manner. Show less