Mansi Parekh
Preclinical Manager - Epilepsy Head at Neurona Therapeutics- Claim this Profile
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Bio
Experience
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Neurona Therapeutics
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United States
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Biotechnology Research
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1 - 100 Employee
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Preclinical Manager - Epilepsy Head
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Jan 2021 - Present
South San Francisco, California, United States
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Scientist II
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Jun 2018 - Dec 2020
South San Francisco, CA
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Scientist
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Nov 2016 - Jun 2018
San Francisco Bay Area
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Stanford University
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United States
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Higher Education
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700 & Above Employee
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Post-Doctoral Associate
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Sep 2012 - Oct 2016
Stanford, CA • Investigate efficacy of new pharmacological compounds including PK studies on animal models of basal cell carcinoma, stroke and TBI • Design and implement drug delivery strategies • screening compounds for drug development for the treatment of lyme disease - in both cell culture and animal models • Investigate structural brain changes due to TBI in football players with concussions and head impact using 3T diffusion MRI. • Design and implement MR acquisition techniques on 7T to… Show more • Investigate efficacy of new pharmacological compounds including PK studies on animal models of basal cell carcinoma, stroke and TBI • Design and implement drug delivery strategies • screening compounds for drug development for the treatment of lyme disease - in both cell culture and animal models • Investigate structural brain changes due to TBI in football players with concussions and head impact using 3T diffusion MRI. • Design and implement MR acquisition techniques on 7T to study brain structural and connectivity measures in the evolving diseased brain in patients with epilepsy. • Investigate brain structural changes associated with memory loss and aging using PET imaging. • Assisted in writing awarded fellowships. Show less
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University of Florida
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United States
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Higher Education
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700 & Above Employee
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Post Doctoral Associate
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Jan 2011 - Sep 2012
• Designed a detailed study to characterize and correlate structural connectivity changes with fMRI changes and behavioral measures of cognition and memory in patients with epilepsy • Designed and executed the acquisition protocol, and analyzed high-level diffusion MRI, for both in vivo and excised specimen to study brain structural connectivity in patients with epilepsy • Performed neuro-psychological evaluations on patients with epilepsy and autism spectrum disorder and subsequently… Show more • Designed a detailed study to characterize and correlate structural connectivity changes with fMRI changes and behavioral measures of cognition and memory in patients with epilepsy • Designed and executed the acquisition protocol, and analyzed high-level diffusion MRI, for both in vivo and excised specimen to study brain structural connectivity in patients with epilepsy • Performed neuro-psychological evaluations on patients with epilepsy and autism spectrum disorder and subsequently correlate with structural and functional MRI results • Directed and managed multiple medical device and drug preclinical studies and clinical trials • Managed regulatory compliance, patient enrollment and data for all human studies pursued in the Carney Lab • Mentored, trained and supervised graduate and undergraduate research students
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Graduate Research Assistant
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Aug 2005 - Dec 2010
• Designed a controlled experiment to characterize longitudinal structural changes that occur in a rat model of temporal lobe epilepsy during epileptogenesis • Carried-out in vivo and excised rat-brain MRI at 4.7T, 11.1T and 17.6T on Bruker and Varian systems. • Performed patient-brain imaging at 3T on Siemens systems • Performed extended analysis of diffusion-weighted measurements using diffusion tensor and higher angular resolution diffusion imaging (HARDI) post-processing methods;… Show more • Designed a controlled experiment to characterize longitudinal structural changes that occur in a rat model of temporal lobe epilepsy during epileptogenesis • Carried-out in vivo and excised rat-brain MRI at 4.7T, 11.1T and 17.6T on Bruker and Varian systems. • Performed patient-brain imaging at 3T on Siemens systems • Performed extended analysis of diffusion-weighted measurements using diffusion tensor and higher angular resolution diffusion imaging (HARDI) post-processing methods; and T1 and T2 measurements • Implemented fiber tracking using HARDI post-processing methods in order to analyze connectivity changes within the limbic structures affected in temporal lobe epilepsy in both epilepsy patients and the rat model of epilepsy • Performed various histological and immunohistochemical techniques in order to assess pathological changes that take place during epileptogenesis in a rat brain • Served as a study coordinator for 2 industry-sponsored clinical trials • Trained new lab members on neuroimaging and analysis; animal surgery and tissue handling.
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Education
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University of Florida
Ph.D, Neuroscience -
University of Florida
B.S, Chemistry; an; Biochemistry