Manouk Vrieling

Molecular Microbiologist/Project Leader at Wageningen Bioveterinary Research
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Contact Information
us****@****om
(386) 825-5501
Location
Lelystad, Flevoland, Netherlands, NL
Languages
  • English -
  • Dutch -

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Credentials

  • Laboratory Animal Science
    Utrecht University
    Mar, 2009
    - Oct, 2024

Experience

  • Wageningen Bioveterinary Research
    • Netherlands
    • Research Services
    • 100 - 200 Employee
    • Molecular Microbiologist/Project Leader
      • Jul 2019 - Present

      My research at Wageningen Bioveterinary Research focuses on investigating host-pathogen interactions in Streptococcus suis infections. Our research goal is to find new solutions to combat S. suis infections in piglets, through vaccine development and other therapeutics or interventions. We aim to unravel the strategies S. suis employs to become pathogenic and cause invasive disease, and also closely study the piglet's immune responses to S. suis to find new measures to improve the host defenses to this bacterium. In addition to the work on S. suis, I also study other important bacterial diseases of livestock (Brucellosis and Staphylococcus aureus) and lead a project aiming to develop new in vitro culture systems to study infectious diseases of pigs and cattle (complex cell systems/organoids). Show less

  • The University of Edinburgh
    • United Kingdom
    • Research Services
    • 700 & Above Employee
    • Post-Doctoral Research Fellow
      • Jun 2017 - Jun 2019

      As a Research Fellow in the Fitzgerald lab I worked on a MRC funded project aiming to identify and characterise key interactions between Staphylococcus aureus and macrophages. In this project I have studied the pathogenesis, evolution and niche adaptation of S. aureus using a combination of lab-based experiments and whole genome sequencing. My project was part of the SHIELD AMR consortium, for more information visit https://shieldamrresearch.org/about/. As a Research Fellow in the Fitzgerald lab I worked on a MRC funded project aiming to identify and characterise key interactions between Staphylococcus aureus and macrophages. In this project I have studied the pathogenesis, evolution and niche adaptation of S. aureus using a combination of lab-based experiments and whole genome sequencing. My project was part of the SHIELD AMR consortium, for more information visit https://shieldamrresearch.org/about/.

  • UMC Utrecht
    • Netherlands
    • Hospitals and Health Care
    • 700 & Above Employee
    • PhD Candidate
      • Aug 2012 - Feb 2017

      Host Adaptation of Staphylococcal Leukocidins (PhD thesis) Supervisors: Prof. Dr. Jos van Strijp, Prof. Dr. Victor Rutten, Dr. Ad Koets During my PhD, I studied the interactions of Staphylococcus aureus with the innate immune system of multiple species. I discovered the molecular interaction partners of important staphylococcal toxins (leukocidins) in humans, cattle and horses. Next, I investigated the pathogenic relevance of these leukocidins in S. aureus infections and studied their suitability as therapeutic targets in a relevant natural host (cattle). This research was part of the ALTANT project (ALTernatives for ANTibiotics) aiming to develop a vaccine for bovine mastitis in collaboration with MSD Animal Health (Boxmeer, The Netherlands). Show less

Education

  • Utrecht University
    Research Honours Programme, Farm Animal Health & Immunology
    2009 - 2010
  • Universiteit Utrecht
    DVM, Veterinary Medicine
    2005 - 2012

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