Mandeep Mann, PhD

Postdoctoral Fellow at Janssen Research & Development, LLC
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Contact Information
us****@****om
(386) 825-5501
Location
Greater Philadelphia

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Experience

    • United States
    • Pharmaceutical Manufacturing
    • 1 - 100 Employee
    • Postdoctoral Fellow
      • Dec 2022 - Present
    • Canada
    • Research Services
    • 1 - 100 Employee
    • PhD Student
      • Sep 2017 - Nov 2022

      • Utilize molecular biology techniques to express and purify proteins • Development and optimization of biophysical assays to screen small molecule compounds against zinc finger ubiquitin binding domains (ZnF-UBDs) - fluorescence polarization (FP) -differential scanning fluorimetry (DSF) -isothermal titration calorimetry (ITC) -surface plasmon resonance (SPR) -19F NMR spectroscopy • X-ray crystallography to determine protein structure • Computational software -ICM-pro -Maestro -Molecular Forecaster FITTED -Coot -Pymol Show less

    • Canada
    • Biotechnology
    • 1 - 100 Employee
    • Intern
      • Mar 2019 - Jun 2019

      • Molecular Forecaster FITTED platform used for virtual screening to identify ligands of interest for USP5 ZnF-UBD • Preliminary docking studies for kinase selectivity • Molecular Forecaster FITTED platform used for virtual screening to identify ligands of interest for USP5 ZnF-UBD • Preliminary docking studies for kinase selectivity

    • Canada
    • Higher Education
    • 700 & Above Employee
    • Research Technican, Kelley Lab, Leslie Dan Faculty of Pharmacy
      • May 2015 - Aug 2015

      • Automation of read-out platform for a diagnostic device for the detection of Hepatitis C virus from whole blood • Use of AutoCad software to design and fabricate a nanostructured chip using nanolithography methods • Optimized flow resistance and design parameters of read-out device using electrochemistry and microfluidic techniques • Automation of read-out platform for a diagnostic device for the detection of Hepatitis C virus from whole blood • Use of AutoCad software to design and fabricate a nanostructured chip using nanolithography methods • Optimized flow resistance and design parameters of read-out device using electrochemistry and microfluidic techniques

    • Canada
    • Higher Education
    • 700 & Above Employee
    • Research Assistant, School of Pharmacy, Waterloo, Drug and Discovery Research Group
      • Jan 2015 - Apr 2015

      • Assisted a senior PhD student with experiments pertaining to drug development projects related to multi-targeted therapy of Alzheimer’s disease • Optimized methodology for synthesis, purification and characterization of a library of quinazoline and pyrimidine derivative compounds • Utilized analytical tools such as column chromatography and proton NMR for purification purposes • Assisted a senior PhD student with experiments pertaining to drug development projects related to multi-targeted therapy of Alzheimer’s disease • Optimized methodology for synthesis, purification and characterization of a library of quinazoline and pyrimidine derivative compounds • Utilized analytical tools such as column chromatography and proton NMR for purification purposes

    • Government Administration
    • 700 & Above Employee
    • Research Laboratory Technician, Aquatic Contaminants Research Division
      • Jan 2012 - Dec 2013

      • Bulk extractions of naphthenic acids from oil sands process water for toxicology assessments and chemical profiling • Pulp and paper extractions to determine the effects of pH on pulp mill effluent • Field collections of chemical and biological samples in oil sands region of Fort McMurray, Alberta • Assisted in development of solid phase extraction method for polar organic compounds from passive sampling devices and analyses by synchronous fluorescence spectroscopy • Bulk extractions of naphthenic acids from oil sands process water for toxicology assessments and chemical profiling • Pulp and paper extractions to determine the effects of pH on pulp mill effluent • Field collections of chemical and biological samples in oil sands region of Fort McMurray, Alberta • Assisted in development of solid phase extraction method for polar organic compounds from passive sampling devices and analyses by synchronous fluorescence spectroscopy

Education

  • University of Toronto
    Doctor of Philosophy - PhD, Pharmacology
    2017 - 2022
  • University of Waterloo
    Bachelor of Science (BSc), Honors Biochemistry, Specialization in Biotechnology
    2012 - 2016

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