Mandeep Mann, PhD
Postdoctoral Fellow at Janssen Research & Development, LLC- Claim this Profile
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Bio
Experience
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Janssen Research & Development, LLC
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Postdoctoral Fellow
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Dec 2022 - Present
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The Structural Genomics Consortium (SGC)
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Canada
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Research Services
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1 - 100 Employee
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PhD Student
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Sep 2017 - Nov 2022
• Utilize molecular biology techniques to express and purify proteins • Development and optimization of biophysical assays to screen small molecule compounds against zinc finger ubiquitin binding domains (ZnF-UBDs) - fluorescence polarization (FP) -differential scanning fluorimetry (DSF) -isothermal titration calorimetry (ITC) -surface plasmon resonance (SPR) -19F NMR spectroscopy • X-ray crystallography to determine protein structure • Computational software -ICM-pro -Maestro -Molecular Forecaster FITTED -Coot -Pymol Show less
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Molecular Forecaster
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Canada
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Biotechnology
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1 - 100 Employee
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Intern
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Mar 2019 - Jun 2019
• Molecular Forecaster FITTED platform used for virtual screening to identify ligands of interest for USP5 ZnF-UBD • Preliminary docking studies for kinase selectivity • Molecular Forecaster FITTED platform used for virtual screening to identify ligands of interest for USP5 ZnF-UBD • Preliminary docking studies for kinase selectivity
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University of Toronto
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Canada
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Higher Education
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700 & Above Employee
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Research Technican, Kelley Lab, Leslie Dan Faculty of Pharmacy
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May 2015 - Aug 2015
• Automation of read-out platform for a diagnostic device for the detection of Hepatitis C virus from whole blood • Use of AutoCad software to design and fabricate a nanostructured chip using nanolithography methods • Optimized flow resistance and design parameters of read-out device using electrochemistry and microfluidic techniques • Automation of read-out platform for a diagnostic device for the detection of Hepatitis C virus from whole blood • Use of AutoCad software to design and fabricate a nanostructured chip using nanolithography methods • Optimized flow resistance and design parameters of read-out device using electrochemistry and microfluidic techniques
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University of Waterloo
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Canada
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Higher Education
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700 & Above Employee
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Research Assistant, School of Pharmacy, Waterloo, Drug and Discovery Research Group
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Jan 2015 - Apr 2015
• Assisted a senior PhD student with experiments pertaining to drug development projects related to multi-targeted therapy of Alzheimer’s disease • Optimized methodology for synthesis, purification and characterization of a library of quinazoline and pyrimidine derivative compounds • Utilized analytical tools such as column chromatography and proton NMR for purification purposes • Assisted a senior PhD student with experiments pertaining to drug development projects related to multi-targeted therapy of Alzheimer’s disease • Optimized methodology for synthesis, purification and characterization of a library of quinazoline and pyrimidine derivative compounds • Utilized analytical tools such as column chromatography and proton NMR for purification purposes
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Environment and Climate Change Canada
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Government Administration
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700 & Above Employee
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Research Laboratory Technician, Aquatic Contaminants Research Division
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Jan 2012 - Dec 2013
• Bulk extractions of naphthenic acids from oil sands process water for toxicology assessments and chemical profiling • Pulp and paper extractions to determine the effects of pH on pulp mill effluent • Field collections of chemical and biological samples in oil sands region of Fort McMurray, Alberta • Assisted in development of solid phase extraction method for polar organic compounds from passive sampling devices and analyses by synchronous fluorescence spectroscopy • Bulk extractions of naphthenic acids from oil sands process water for toxicology assessments and chemical profiling • Pulp and paper extractions to determine the effects of pH on pulp mill effluent • Field collections of chemical and biological samples in oil sands region of Fort McMurray, Alberta • Assisted in development of solid phase extraction method for polar organic compounds from passive sampling devices and analyses by synchronous fluorescence spectroscopy
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Education
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University of Toronto
Doctor of Philosophy - PhD, Pharmacology -
University of Waterloo
Bachelor of Science (BSc), Honors Biochemistry, Specialization in Biotechnology