Makram Mghezzi-Habellah
Étudiant doctorant at Laboratory of Biology and Modeling of the Cell- Claim this Profile
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Français Native or bilingual proficiency
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Anglais Full professional proficiency
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Bio
Credentials
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Licence Génétique et Biologie Celluaire
Université Claude Bernard Lyon 1Jun, 2020- Sep, 2024 -
Prévention et gestions des risques en laboratoire (CNRS/Neo)
École normale supérieure de LyonJun, 2018- Sep, 2024 -
Computing and Internet certificate
Université Claude Bernard Lyon 1Jun, 2016- Sep, 2024 -
TOEIC® Listening and Reading test
ETSOct, 2021- Sep, 2024
Experience
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Laboratory of Biology and Modeling of the Cell
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France
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Research Services
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1 - 100 Employee
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Étudiant doctorant
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Oct 2022 - Present
PhD student to study post-transcriptionnal regulation and especially, non-sense mediated decay (NMD). Relative importance of the CRM1 pathway in NMD decay and virus biology PhD student to study post-transcriptionnal regulation and especially, non-sense mediated decay (NMD). Relative importance of the CRM1 pathway in NMD decay and virus biology
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Supervision of an IGEM team
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Jun 2021 - Oct 2022
Supervision of an iGem team for the year 2022. Team from the Lyon University: IGEM INSA Lyon I. The goal of the project is the development of a "FiatLUX" package including the bioluminescent conjugative plasmid (luxCDABE), hardware for the acquisition of in vivo images of infection in planta and eco-friendly software for analysis images. Roles: - participation in the genesis of the project and judging the feasibility - bibliographic watch - validation of the scientific approach of the students involved in the projects - promoting the project to companies (eg Bayer). The team was the most awarded during the grand final (6 prizes) and obtained a final ranking of 2nd out of 250 registered teams. To more détail : https://2022.igem.wiki/insa-lyon1/index.html https://www.insa-lyon.fr/fr/actualites/igem-fiat-lux-bacteries-phytopathogenes-luminescentes Show less
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M2 research internship
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Jan 2022 - Jul 2022
Internship to study the NMD inhibition by HTLV-1 protein and description of hijack mechanism of UPF1 in this infection. And also to evaluate the shutting as a NMD potentiel inhibition pathway in cell. Article in progress. Supervised by MOCQUET Vincent, CR INSERM. Skills : RNA-Binding proteins immunoprecipitation, immunoprecipitation, cell culture, bacterial genetic, RNA-seq. Internship to study the NMD inhibition by HTLV-1 protein and description of hijack mechanism of UPF1 in this infection. And also to evaluate the shutting as a NMD potentiel inhibition pathway in cell. Article in progress. Supervised by MOCQUET Vincent, CR INSERM. Skills : RNA-Binding proteins immunoprecipitation, immunoprecipitation, cell culture, bacterial genetic, RNA-seq.
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Institut Pasteur
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France
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Research Services
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700 & Above Employee
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Research intership
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Feb 2022 - Feb 2022
Participation of the international course "Multiples roles of RNAs". Transcriptomic analysis to illustrate target diversity of a major RNA degradation pathway NMD. Participation of the international course "Multiples roles of RNAs". Transcriptomic analysis to illustrate target diversity of a major RNA degradation pathway NMD.
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Research Internship
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Jun 2021 - Jul 2021
Internship to characterize the interaction between a cell cycle protein and ribosome during a viral infection • ENS LYON Internship supervised by David Cluet (david.cluet@ens-lyon.fr), IR1, RMI2 lab Familiarization with cell culture of adherent cells (HEK293T), cell transfection and CRISPaint, Immunoprecipitation, Western Blot. Side project: cloning of SunTag in a plasmid expressing the entire SINV genome in a “single cell imaging” project in order to follow viral translation into a single molecule. Show less
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Université Claude Bernard Lyon 1
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France
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Higher Education
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700 & Above Employee
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University Student
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Sep 2016 - Jul 2021
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INTERNSHIP AIMING TO CHARACTERIZE THE MOLECULAR IDENTITY OF A MUTANT OF STERELITIS AT DROSOPHILA MEL
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Mar 2019 - Mar 2019
Project supervised by Raphaëlle Dubruille CR, CNRS (team:Epigenetics and Zygote Formation, LMBC Lyon)- Formulation of hypotheses, development of an experimental strategy. Comparison of the expected results with the hypotheses. Bibliographic research (PubMed).- Drosophila genetics, RNA extraction and RT-PCR, PCR genotyping.Skills: Drosophila genetics, molecular biology technique (PRC, DNA extraction, RNA extraction, RT-PCR, agarose gel electrophoresis), internship report writing, bibliographic reading, epifluorescence microscopy, Fiji manipulation. Show less
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TECHNICAL ASSISTANCE FOR THE M2 INTERNSHIP PROJECT
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Apr 2019 - May 2019
Subject: Study of transcriptional variability between two sister cells with the aim of measuring by scRNAseq (MARS-seq) - Gandrillon team, CNRS. - Familiarization with the technical skills of this project: cell culture (6C2 - avian erythrocyte progenitors, P2), fluorescence microscope observation, cell isolation by capillarity. - Presentation of results in English during team meetings. - Discovery of sequencing methods (IGFL Lyon) Due to a rather limited internship period, the topic could not be explored as a whole. In this lapse of time, my goal was rather to "design" different protocols for answers to the biological question. Skills: cell culture, keeping a laboratory notebook, epifluorescence microscopy, cell isolation by capillary action, bibliographic reading. Show less
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INTERNSHIPS DURING MY SECOND YEAR OF BACHELOR'S DEGREE
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Jun 2018 - Jun 2018
Systems Biology of Decision Making Team (Gandrillon) / LBMC Internship subject: Transcription and differentiation of T2EC. To determine if transcription is an essential process for the differentiation of the cell model, erythrocyte progenitors. Skills: cell culture, cell thawing, inhibition of transcription by Actinomycin D and visualization of the effects of inhibition by microscope, reading the literature (PubMed) Systems Biology of Decision Making Team (Gandrillon) / LBMC Internship subject: Transcription and differentiation of T2EC. To determine if transcription is an essential process for the differentiation of the cell model, erythrocyte progenitors. Skills: cell culture, cell thawing, inhibition of transcription by Actinomycin D and visualization of the effects of inhibition by microscope, reading the literature (PubMed)
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Education
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2021 - 2022
Université Pierre et Marie Curie
Master of Science - MS, Biochemistry of RNA -
2020 - 2021
Université Claude Bernard Lyon 1
Master of Science - MS, Molecular microbiology -
2016 - 2020
Université Claude Bernard Lyon 1
Bachelor of Applied Science - BASc, Genetics and cell biology -
2018 - 2018
École normale supérieure de Lyon
Certificate of professional competence, Chemical risk prevention in a laboratory (CNRS/NEO)
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