Senior Principal Scientist

• Jan 2023 - Present

Principal Scientist

• May 2021 - Mar 2023

– Oversee the design and data-review of pre-clinical studies – Pilot studies testing safety and efficacy of vectors using rodents in house – Regulatory of the cooperations with CROs – Apply gene therapies to treat retinal diseases – Assay development for pre-clinical projects – Quality control – Oversee the design and data-review of pre-clinical studies – Pilot studies testing safety and efficacy of vectors using rodents in house – Regulatory of the cooperations with CROs – Apply gene therapies to treat retinal diseases – Assay development for pre-clinical projects – Quality control

Scientist II

• Jan 2019 - May 2021

– Lead the projects of neuro-protection and neuro-regeneration related ophthalmological diseases using gene therapies (viral and non-viral deliveries) and other modalities – Oversee the assay developments to evaluate the efficacy of neuro-protection and neuro-regeneration – In charge of model generation of ocular diseases: ocular hypertension glaucoma model and optic nerve crush, TNF-a induced RGC death model – Neuroprotection by modifying inflammasome pathways – Lead the POC studies using SM, viral and non-viral treatments in ocular diseases – IACUC committee Show less

Senior Scientist

• Jul 2016 - Jan 2019

Playing a key role in the Retinal Progenitor Program. Working on stem cell (iPS cells and ES cells) culture/maintain and stem cell differentiation for cell therapy. I was in charge of in vivo studies using cell therapies to treat rodent models with inherited ocular diseases including retinal photoreceptor degeneration, retinitis pigmentosa, and generating ocular diseases models including optic nerve degeneration and ocular hypertension. Playing a key role in the Retinal Progenitor Program. Working on stem cell (iPS cells and ES cells) culture/maintain and stem cell differentiation for cell therapy. I was in charge of in vivo studies using cell therapies to treat rodent models with inherited ocular diseases including retinal photoreceptor degeneration, retinitis pigmentosa, and generating ocular diseases models including optic nerve degeneration and ocular hypertension.

Instructor, Junior Faculty

• Feb 2014 - Jul 2016

Generated ocular disease rodent models including age-related macular degeneration (AMD), ocular hypertension (glaucoma) and optic nerve degeneration; Intravitreally administrated gene therapy, cell therapy and specific inhibitor/receptor to treat AMD or glaucomatous mice; Estimated solid method to quantify retinal ganglion cells (RGCs) using specific markers; Investigated inflammation enhancing RGC death in gluacomatous mice. As a key investigator, I was in charge of supervising students and technicians in the lab and managing the projects. Show less

Investigator, Junior Faculty

• Feb 2014 - Jul 2016

Generated ocular disease rodent models including age-related macular degeneration (AMD), ocular hypertension (glaucoma) and optic nerve degeneration; Intravitreally administrated gene therapy, cell therapy and specific inhibitor/receptor to treat AMD or glaucomatous mice; Estimated solid method to quantify retinal ganglion cells (RGCs) using specific markers; Investigated inflammation enhancing RGC death in gluacomatous mice. As a key investigator, I was in charge of supervising students and technicians in the lab and managing the projects. Show less

Postdoctoral Fellow

• Mar 2011 - Jan 2014

Generated ocular disease rodent models including age-related macular degeneration (AMD), ocular hypertension (glaucoma) and optic nerve degeneration; Intravitreally administrated gene therapy, cell therapy and specific inhibitor/receptor to treat AMD or glaucomatous mice; Estimated solid method to quantify retinal ganglion cells (RGCs) using specific markers; Investigated inflammation enhancing RGC death in gluacomatous mice. As a key investigator, I was in charge of supervising students and technicians in the lab and managing the projects. Show less

Research Associate

• Aug 2009 - Mar 2011

Studies of neurophysiology, neuro-morphology and pharmacology.

Postdoctoral Fellow

• Jul 2008 - Jul 2009

Studies of neurophysiology and animal behavior

Postdoctoral Fellow

• Mar 2004 - Feb 2007

Neurophysiology, pharmacology, animal behavior Neurophysiology, pharmacology, animal behavior