Experience

EpiBiologics
• United States
• Biotechnology Research
• 1 - 100 Employee
• Senior Director of Protein Sciences

  • Nov 2022 - Present


Stealth Mode Startup Biotech

• Founder and Advisor

  • Nov 2022 - Present

• Founder and Vice President of Research and Discovery

  • May 2022 - Oct 2022



Maverick Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Director (Protein Sciences)

  • Jul 2020 - Apr 2022

• Director (Protein Sciences)

  • Jan 2017 - Jun 2020

  - Design of T-cell engaging bispecific protein therapeutics for cancer treatment - Platform development for the drugs conditionally activated by tumor micro environment - Enzyme based assays - Building and managing the Protein Production and Protein Analytics units of the company - Support of CMC work (assay development, cell line selection, process development, protein lot release)



Harpoon Therapeutics

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Senior Scientist

  • Aug 2016 - Jan 2017

  Protein chemistry.Construct design and optimization of novel protein drugs for cancer immunotherapy. Antibody-based assays (ELISA, FACS) Protein chemistry.Construct design and optimization of novel protein drugs for cancer immunotherapy. Antibody-based assays (ELISA, FACS)



Genentech

• United States
• Biotechnology Research
• 700 & Above Employee

• Senior Scientific Researcher

  • Jul 2012 - Aug 2016

  - Protein production and crystallization - Diverse projects from the small molecule drug development portfolio - Structural analysis. Participant of medchem design project teams PUBLICATIONS: M. Vinogradova#, V. S. Gehling#, A. Gustafson, S. Arora, C. A. Tindell, C. Wilson, K. E. Williamson, G. D. Guler, P. Gangurde, W. Manieri, J. Busby, E. M. Flynn, F. Lan, H. Kim, S. Odate, A. G. Cochran, Y. Liu, M. Wongchenko, Y. Yang, T. K. Cheung, T. M. Maile, T. Lau, M. Costa, G. V… Show more - Protein production and crystallization - Diverse projects from the small molecule drug development portfolio - Structural analysis. Participant of medchem design project teams PUBLICATIONS: M. Vinogradova#, V. S. Gehling#, A. Gustafson, S. Arora, C. A. Tindell, C. Wilson, K. E. Williamson, G. D. Guler, P. Gangurde, W. Manieri, J. Busby, E. M. Flynn, F. Lan, H. Kim, S. Odate, A. G. Cochran, Y. Liu, M. Wongchenko, Y. Yang, T. K. Cheung, T. M. Maile, T. Lau, M. Costa, G. V. Hegde, E. Jackson, R. Pitti, D.Arnott, C. Bailey, S. Bellon, R. T. Cummings, B. K. Albrecht, J.-C. Harmange, J.R. Kiefer, P. Trojer, and M.Classon. An inhibitor of the KDM5 demethylases reduces the survival of drug-tolerant cancer cells (2016) Nature Chem Biol Show less - Protein production and crystallization - Diverse projects from the small molecule drug development portfolio - Structural analysis. Participant of medchem design project teams PUBLICATIONS: M. Vinogradova#, V. S. Gehling#, A. Gustafson, S. Arora, C. A. Tindell, C. Wilson, K. E. Williamson, G. D. Guler, P. Gangurde, W. Manieri, J. Busby, E. M. Flynn, F. Lan, H. Kim, S. Odate, A. G. Cochran, Y. Liu, M. Wongchenko, Y. Yang, T. K. Cheung, T. M. Maile, T. Lau, M. Costa, G. V… Show more - Protein production and crystallization - Diverse projects from the small molecule drug development portfolio - Structural analysis. Participant of medchem design project teams PUBLICATIONS: M. Vinogradova#, V. S. Gehling#, A. Gustafson, S. Arora, C. A. Tindell, C. Wilson, K. E. Williamson, G. D. Guler, P. Gangurde, W. Manieri, J. Busby, E. M. Flynn, F. Lan, H. Kim, S. Odate, A. G. Cochran, Y. Liu, M. Wongchenko, Y. Yang, T. K. Cheung, T. M. Maile, T. Lau, M. Costa, G. V. Hegde, E. Jackson, R. Pitti, D.Arnott, C. Bailey, S. Bellon, R. T. Cummings, B. K. Albrecht, J.-C. Harmange, J.R. Kiefer, P. Trojer, and M.Classon. An inhibitor of the KDM5 demethylases reduces the survival of drug-tolerant cancer cells (2016) Nature Chem Biol Show less



UCSF

• United States
• Higher Education

• Research scientist

  • Feb 1999 - Jul 2012

  - Biochemistry. Protein expression, purification, protein crystallography, structure determination - Projects on motor proteins (kinesins, myosins) and their regulation (calmodulin, troponin), nuclear receptors and their small molecule modulators. SELECTED PUBLICATIONS: Vinogradova, M.V., Malanina, G.G., Waitzman, J.S., Rice, S.E., Fletterick, R.J. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. (2013) PLoS One, 8(6)… Show more - Biochemistry. Protein expression, purification, protein crystallography, structure determination - Projects on motor proteins (kinesins, myosins) and their regulation (calmodulin, troponin), nuclear receptors and their small molecule modulators. SELECTED PUBLICATIONS: Vinogradova, M.V., Malanina, G.G., Waitzman, J.S., Rice, S.E., Fletterick, R.J. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. (2013) PLoS One, 8(6), e66669. Benod, C., Vinogradova, M.V., Jouravel, N., Kim, G.E., Fletterick, R.J., Sablin, E. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. (2011) PNAS, 108, 16927-31. Vinogradova, M.V., Malanina, G.G., Reddy, A.S.N., Fletterick, R.J. Structure of the complex of a mitotic kinesin with its calcium binding regulator. (2009) PNAS, 106, 8175-9. Vinogradova, M.V., Stone, D.B., Malanina, G.G., Mendelson, R.A., Karatzaferi, C., Cooke, R., Fletterick, R.J. Ca2+-regulated structural changes in troponin. (2005) PNAS, 102(14), 5038-43. Vinogradova, M.V., Reddy, V.S., Reddy, A.S., Sablin, E.P., Fletterick, R.J. Crystal structure of Kinesin regulated by Ca2+-calmodulin. (2004) J. Biol. Chem., 279(22), 23504-9. Show less - Biochemistry. Protein expression, purification, protein crystallography, structure determination - Projects on motor proteins (kinesins, myosins) and their regulation (calmodulin, troponin), nuclear receptors and their small molecule modulators. SELECTED PUBLICATIONS: Vinogradova, M.V., Malanina, G.G., Waitzman, J.S., Rice, S.E., Fletterick, R.J. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. (2013) PLoS One, 8(6)… Show more - Biochemistry. Protein expression, purification, protein crystallography, structure determination - Projects on motor proteins (kinesins, myosins) and their regulation (calmodulin, troponin), nuclear receptors and their small molecule modulators. SELECTED PUBLICATIONS: Vinogradova, M.V., Malanina, G.G., Waitzman, J.S., Rice, S.E., Fletterick, R.J. Plant Kinesin-Like Calmodulin Binding Protein Employs Its Regulatory Domain for Dimerization. (2013) PLoS One, 8(6), e66669. Benod, C., Vinogradova, M.V., Jouravel, N., Kim, G.E., Fletterick, R.J., Sablin, E. Nuclear receptor liver receptor homologue 1 (LRH-1) regulates pancreatic cancer cell growth and proliferation. (2011) PNAS, 108, 16927-31. Vinogradova, M.V., Malanina, G.G., Reddy, A.S.N., Fletterick, R.J. Structure of the complex of a mitotic kinesin with its calcium binding regulator. (2009) PNAS, 106, 8175-9. Vinogradova, M.V., Stone, D.B., Malanina, G.G., Mendelson, R.A., Karatzaferi, C., Cooke, R., Fletterick, R.J. Ca2+-regulated structural changes in troponin. (2005) PNAS, 102(14), 5038-43. Vinogradova, M.V., Reddy, V.S., Reddy, A.S., Sablin, E.P., Fletterick, R.J. Crystal structure of Kinesin regulated by Ca2+-calmodulin. (2004) J. Biol. Chem., 279(22), 23504-9. Show less


Moscow State University
• Russian Federation
• Higher Education
• 700 & Above Employee
• Ph D student

  • 1992 - 1995