Luca Tottone

Assistant Scientist at Sylvester Comprehensive Cancer Center
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Contact Information
us****@****om
(386) 825-5501
Location
Miami, Florida, United States, US

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Bio

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Credentials

  • Aseptic surgery
    CITI Program
    May, 2022
    - Oct, 2024
  • Conflict of Interest
    CITI Program
    May, 2022
    - Oct, 2024
  • IACUC Chairs, Members and Coordinators
    CITI Program
    May, 2022
    - Oct, 2024
  • Reducing Pain and Distress
    CITI Program
    May, 2022
    - Oct, 2024
  • University of Miami, OHandS and SOPs
    CITI Program
    May, 2022
    - Oct, 2024
  • Working with Mice in Research
    CITI Program
    May, 2022
    - Oct, 2024
  • Working with the IACUC
    CITI Program
    May, 2022
    - Oct, 2024

Experience

  • Sylvester Comprehensive Cancer Center
    • United States
    • Hospitals and Health Care
    • 300 - 400 Employee
    • Assistant Scientist
      • May 2022 - Present

      Senior Scientist focused on describing the epigenetic and transcriptional mechanisms that characterize both the physiological differentiation of myeloid lineage and the pathological transformation of myeloid precursors into Acute Myeloid Leukemia (AML). Senior Scientist focused on describing the epigenetic and transcriptional mechanisms that characterize both the physiological differentiation of myeloid lineage and the pathological transformation of myeloid precursors into Acute Myeloid Leukemia (AML).

  • Rutgers Cancer Institute of New Jersey
    • United States
    • Hospitals and Health Care
    • 500 - 600 Employee
    • Postdoctoral Researcher
      • Mar 2018 - May 2022

      Postdoctoral fellow dissecting the epigenetic modifications that affect T-Cell Acute Lymphoblastic Leukemia (T-ALL) onset and resistance to therapies. By mastering state-of-the-art techniques in genome analysis, I identified a tumor suppressor enhancer of PTEN in T-ALL (PE) located ~550Kb downstream to the gene TSS. PE shows high levels of interaction with the PTEN promoter and plays a major role in T-cell development and transformation. Postdoctoral fellow dissecting the epigenetic modifications that affect T-Cell Acute Lymphoblastic Leukemia (T-ALL) onset and resistance to therapies. By mastering state-of-the-art techniques in genome analysis, I identified a tumor suppressor enhancer of PTEN in T-ALL (PE) located ~550Kb downstream to the gene TSS. PE shows high levels of interaction with the PTEN promoter and plays a major role in T-cell development and transformation.

  • Istituto Italiano di Tecnologia
    • Italy
    • Research Services
    • 700 & Above Employee
    • Scientific Researcher
      • Oct 2016 - Mar 2018

      Leukemia specialist involved in the identification of novel inhibitors of the oncogene NOTCH1. Starting from an in-house library of natural molecules, I screened, identified and refined Compound 8 (C8), a chalcone derivative showing potent anti-leukemic and Notch inhibitory activity at low micro molar concentration. Notably, this research led to a first-author publication and to an international patent deposit (US011104657B2) Leukemia specialist involved in the identification of novel inhibitors of the oncogene NOTCH1. Starting from an in-house library of natural molecules, I screened, identified and refined Compound 8 (C8), a chalcone derivative showing potent anti-leukemic and Notch inhibitory activity at low micro molar concentration. Notably, this research led to a first-author publication and to an international patent deposit (US011104657B2)

Education

  • Sapienza Università di Roma
    Doctor of Philosophy - PhD, Molecular Medicine
    2013 - 2016
  • Sapienza Università di Roma
    Master's degree, Molecular Medicine
    2011 - 2013
  • Università degli Studi di Teramo
    Bachelor's degree, Biotechnology
    2007 - 2010

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