Experience

Cyclenium Pharma Inc.

• Canada
• Biotechnology Research
• 1 - 100 Employee

• Principal Research Associate

  • Feb 2014 - Present

  Purification and analysis of libraries of macrocyclic compounds using Preparative HPLC and analytical UPLC Assembly of libraries of macrocyclic compounds using solid support synthesis. Synthesis of building blocks Purchase coordination and inventory maintenance for all commercial and synthetic chemicals and building blocks and final macrocyclic library compounds. Export coordination of macrocyclic library compounds to research partners. Purification and analysis of libraries of macrocyclic compounds using Preparative HPLC and analytical UPLC Assembly of libraries of macrocyclic compounds using solid support synthesis. Synthesis of building blocks Purchase coordination and inventory maintenance for all commercial and synthetic chemicals and building blocks and final macrocyclic library compounds. Export coordination of macrocyclic library compounds to research partners.



Tranzyme Pharma

• Senior Research Associate, Analytical Chemistry

  • Dec 2010 - Nov 2013

  - Purification of combinatorial library of small peptidic compounds by Preparative HPLC/MS chromatography using MassLynx interface. - Developped and optimized the chromatographic methods to purify 125 to 250 compounds/week at 1mg to 20mg of purified material scale. - Maintenance and troubleshooting of Waters Prep-HPLC/MS instrument with sample manager and Waters UPLC instrument. - Synthesis of building blocks for the preparation of combinatorial libraries of small peptidic compounds Show less



Wyeth Research / Pfizer

• Research scientist

  • Apr 1993 - 2010

  Process Chemistry & Research -Designed and performed laboratory work to invent and improve chemical processes for the production of pharmaceutical intermediates and active ingredients leading to experimental procedures suitable for Kilo-Lab or Pilot Plant operations. -Applied state-of-the-art technology to accelerate the development of chemical processes (DOE, RSM, QbD, PAT, High throughput screening, Continuous flow and CSTR chemistry, etc). - Drafted Standard Laboratory Procedures, wrote reports on experimental data and participated in technology transfer meetings. - Was present for initial plant runs of processes based on experimental work to carry out in-process tests and render real time advice. Analytical Chemistry - Developped and executed analytical methods for monitoring of chemical process and the characterization of isolated pharmaceutical intermediates using HPLC (Empower & Chemstation operating systems), UPLC, LC/MS, NMR, GC, TLC, etc. - Designed simple and reliable in-process tests for monitoring of reactions in the laboratory and in the pilot plant. - Assured the maintenance of several analytical instruments in the laboratory (Agilent HPLC, Waters HPLC, UPLC, UPLC/MS). Instrumentation & Technologies - Fouding member of the Process Chemistry Technonogies group at Wyeth (2002-2010) - Tested, evaluated and integrated new technologies and techniques into the Chemical Development work flow (High throughput screening, Automated parallel chemistry, Process Analytical Technologies (PAT), Design of Experiment (DOE), Quality by Design (QbD), Flow chemistry, etc. - Served as trainer and point person on the lab instrumentation for Chemical Development chemists in Montreal. - Assured maintenance of laboratory instrumentation. GMP Production - Synthetized intermediates and active ingredient of a commercial veterinary drug (200 to 500g scale) following Good Manufacturing Practice (GMP) procedures. Show less