Louise Klem
Research Scientist at Vesper Bio ApS- Claim this Profile
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English Native or bilingual proficiency
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Danish Native or bilingual proficiency
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French Elementary proficiency
Topline Score
Bio
Credentials
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Laboratory Animal Science EU Function A/B/D (category C)
FEDERATION OF EUROPEAN LABORATORY ANIMAL SCIENCE ASSOCIATIONSJul, 2017- Nov, 2024
Experience
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Vesper Bio
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Denmark
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Biotechnology Research
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1 - 100 Employee
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Research Scientist
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Oct 2022 - Present
In my current position, I support the preclinical development of novel therapies to address unmet needs within neurodegenerative diseases. My tasks include reviewing literature, planning PK/PD and disease model experiments, and providing data management, analysis, and interpretation. In my current position, I support the preclinical development of novel therapies to address unmet needs within neurodegenerative diseases. My tasks include reviewing literature, planning PK/PD and disease model experiments, and providing data management, analysis, and interpretation.
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Lundbeck
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Denmark
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Pharmaceutical Manufacturing
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700 & Above Employee
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Project Worker
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Jun 2022 - Sep 2022
I worked on fixed-term projects at Lundbeck across different departments, including on a research project investigating in vitro alternatives to a cytotoxicity assay and an in vivo skin irritation assay. The aim of this project was to improve animal welfare and potentially increase the predictive capabilities of the animal models and experiments. I also organised a vehicle database, to provide an overview of the toxicological data. I worked on fixed-term projects at Lundbeck across different departments, including on a research project investigating in vitro alternatives to a cytotoxicity assay and an in vivo skin irritation assay. The aim of this project was to improve animal welfare and potentially increase the predictive capabilities of the animal models and experiments. I also organised a vehicle database, to provide an overview of the toxicological data.
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Dept. of Drug Design and Pharmacology (ILF), University of Copenhagen
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Denmark
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Research Services
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1 - 100 Employee
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PHD Fellow
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Sep 2018 - Feb 2022
This research project examines pharmacological and chemogenetic interventions in the rodent continuous performance test, to assess the impact of dopamine and noradrenaline on attention and impulsivity. We also examine the contribution of different neurotransmitter receptor families towards the therapeutic effects of ADHD medications. I have also had the pleasure of supervising several master students over the years, who contributed to the project. Main Supervisor: Associate Professor Jesper T. Andreasen, PhD Co-supervisor: Assistant Professor Andreas T. Sørensen, PhD Co-supervisor: Associate Professor David P. D. Woldbye, PhD, MD Show less
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Master Thesis Student
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Sep 2017 - Jun 2018
This research project explored the use of gene therapy as an emerging treatment strategy for pharmaco-resistant epilepsy, affecting 30-40% of epilepsy patients. Therapeutic transgene overexpression was mediated through adeno-associated viral vectors delivered to the rodent hippocampus through stereotaxic surgery. The seizure-suppressant effects were examined in a kainic acid seizure model, with side effects on memory assessed in the Morris water maze and Y maze for spontaneous alternation. Viral vector expression was examined through immunohistochemistry staining and the quantitative polymerase chain reaction assay. Supervisor: Associate Professor David P. D. Woldbye, PhD, MD Show less
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Novo Nordisk
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Denmark
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Pharmaceutical Manufacturing
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700 & Above Employee
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Intern, Biopharm
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Feb 2016 - Aug 2016
This was a fixed-term internship in Hemophilia Factor Vlll treatment in Biopharm, Novo Nordisk. I supported the development and implementation of a new IT-based production planning system (Access Orchestrate), in order to optimise resources, prevent scheduling errors, and minimise waste. In this regard, I was very fortunate to collaborate with several different parties to collect different input for the functionality of the new system. I also developed educational material and held instructional sessions on the topic of the new planning system. Furthermore, I participated in the development of cLEAN systems to identify error types and solutions, which further supported the department's goal of minimising flaws within API production. Show less
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Labster
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Denmark
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E-Learning Providers
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100 - 200 Employee
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Assistant
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Dec 2014 - Feb 2016
While still maintaining my responsibilities as Translator/Proofreader, I was promoted to Assistant at Labster. In this context, I was tasked with researching potential candidates for available positions, coordinating and managing special projects, and assisting with various assignments.
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Translator/Proofreader
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Oct 2014 - Feb 2016
In this context, I have had the pleasure of working with Labster's virtual laboratories. These are aimed at the betterment of E-learning within STEM-pathways of education. My main function at Labster has been proofreading and bugtesting both Danish and English virtual laboratories. In this regard, I have also assisted with translation of the English laboratories to Danish and vice versa.
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Education
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2015 - 2017
Københavns Universitet
MSc Pharmaceutical Sciences, Drug Discovery -
2012 - 2015
Københavns Universitet
Bachelor of Pharmacy -
2008 - 2011
Borupgaard Gymnasium
Biology A, Physical Education B, Mathematics B.
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