Linnea Herzog
Scientist I, Early Preclinical Development at Akouos- Claim this Profile
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English -
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Bio
Experience
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Akouos
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United States
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Biotechnology
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1 - 100 Employee
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Scientist I, Early Preclinical Development
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May 2022 - Present
• Perform cochlear function testing (ABR, DPOAE) in mouse models of hearing loss. • Assist and perform intracochlear delivery surgery. • Maintain accurate documentation of experiments and projects. • Analyze physiology and behavioral data using Python and write report. • Attend and present data at internal and public scientific meetings. • Help management of experiments within the EPD team, and coordinate activities between surgical teams, physiology and necropsy, and histology. • Assist with IACUC protocol writing. • Provide training for physiology and surgery team. Show less
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Broad Institute of MIT and Harvard
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Research Services
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700 & Above Employee
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Postdoctoral Associate
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Feb 2020 - May 2022
Principal Investigator: Morgan Sheng, M.D., Ph.D. Project: In vivo physiology of genetic animal models of psychiatric disease • Designed, conducted, and analyzed in vivo physiology studies to characterize mouse models of schizophrenia and bipolar disorder identified from human genetics. • Developed and implemented experiments to evaluate the activity of novel drug candidates. • Identified EEG biomarkers shared between mouse models and human patients. • Collaborated with diverse research teams to present, interpret and synthesize results. • Analyzed physiology and behavioral datasets using MATLAB and Python. • Prepared and delivered scientific presentations at lab and program meetings, including a poster at the Stanley Center Symposium for Severe Mental Illness (October 2021) and invited talk at the Broad Institute Retreat (December 2021). • Published findings in a peer-reviewed journal ("Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients," Translational Psychiatry, 2023). • Performed rodent stereotaxic surgery, post-operative care, colony and animal protocol management. • Mentored and provided training to postdocs, technicians and students, including in the Broad Summer Research Program, 2021. Show less
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Brandeis University
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United States
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Higher Education
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700 & Above Employee
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Graduate Researcher
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Sep 2014 - Jan 2020
Advisors: Donald B. Katz, Ph.D and Shantanu Jadhav, Ph.D Dissertation: Mapping out taste in the hippocampus • Conducted chronic multi-electrode recordings in awake, behaving rats to determine how the hippocampus responds to gustatory stimuli. • Provided the first evidence that hippocampal place cells respond to tastes, and that these sensory responses are confined to the cell’s place field. • Constructed and integrated a novel intra-oral taste delivery system for in vivo electrophysiology and behavioral experiments. • Developed programs for single-cell and population analyses using MATLAB. • Designed experimental protocols that fostered a new line of research and collaboration between two labs at Brandeis. • Mentored and provided training to technicians, undergraduate and graduate students. • Published research in peer-reviewed journals, including 2 first-author publications (“Refinement and reactivation of a taste-responsive hippocampal network,” Current Biology, 2020; “Interaction of taste and place coding in the hippocampus,” The Journal of Neuroscience, 2019), and a co-authored review (“The function of groups of neurons changes from moment to moment,” Current Opinion in Physiology, 2020). • Presented findings to a variety of scientific audiences (4 conference presentations, including Society for Neuroscience and Association for Chemoreception Sciences annual meetings; won 2 travel awards to attend conferences). Show less
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Boston University
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United States
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Higher Education
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700 & Above Employee
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Senior Research Technician
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Jun 2012 - Aug 2014
Principal Investigator: Ian Davison, Ph.D. Project: Circuits for innate odor preference • Developed cellular, molecular and behavioral experiments to analyze mice’s responses to naturalistic olfactory stimuli. • Analyzed intrinsic signal imaging data sets using MATLAB. • Managed laboratory logistical and financial operations, including mouse colony, lab safety, and compliance. Principal Investigator: Ian Davison, Ph.D. Project: Circuits for innate odor preference • Developed cellular, molecular and behavioral experiments to analyze mice’s responses to naturalistic olfactory stimuli. • Analyzed intrinsic signal imaging data sets using MATLAB. • Managed laboratory logistical and financial operations, including mouse colony, lab safety, and compliance.
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Wellesley College
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United States
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Higher Education
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700 & Above Employee
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Undergraduate Research Assistant
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Jun 2009 - May 2012
Advisor: Michael C. Wiest, Ph.D. Honors Thesis: Frontal-parietal coherence as a neural correlate of attention • Performed multi-electrode electrophysiological recordings in awake, behaving rats to investigate the relationship between attention and frontal-parietal oscillatory activity. • Developed programs for spectral analysis of power, coherence, and event-related potentials using MATLAB. • Optimized behavioral paradigms assessing auditory responses and attention in rats. • Designed a multi-year research project leading to 1 first-author publication (“Prestimulus frontal-parietal coherence predicts auditory detection performance in rats,” Journal of Neurophysiology, 2014), 6 institutional grants and awards, and 7 conference presentations. Show less
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Education
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Brandeis University
Doctor of Philosophy (Ph.D.), Neuroscience -
Wellesley College
Bachelor's Degree, Neuroscience