Linh Le
Doctoral Candidate at University of Rochester School of Medicine and Dentistry- Claim this Profile
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French Elementary proficiency
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English Native or bilingual proficiency
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Vietnamese Native or bilingual proficiency
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Bio
Experience
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University of Rochester School of Medicine and Dentistry
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United States
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Higher Education
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200 - 300 Employee
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Doctoral Candidate
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May 2021 - Present
Studying the complex role of microglia, the innate immune cells of the central nervous system, in health and disease contexts. Advisors: Dr. Ania K. Majewska & Dr. Kerry M. O’Banion • Conceived, designed and conducted research experiments as lead author to: o Demonstrate the contribution of microglial β2 adrenergic signaling in regulating Alzheimer’s disease (AD) pathology using the 5xFAD mouse model of AD o Investigate sexual dimorphism in microglial survival… Show more Studying the complex role of microglia, the innate immune cells of the central nervous system, in health and disease contexts. Advisors: Dr. Ania K. Majewska & Dr. Kerry M. O’Banion • Conceived, designed and conducted research experiments as lead author to: o Demonstrate the contribution of microglial β2 adrenergic signaling in regulating Alzheimer’s disease (AD) pathology using the 5xFAD mouse model of AD o Investigate sexual dimorphism in microglial survival mechanisms o Reveal marginal impact of microglia repopulation via pharmacologically-induced depletion on both molecular pathology and cognitive deficits in APP/PS1 and 3xTg rodent models of AD • Contributed as co-author to 3 published and the following 3 ongoing studies: o Developed analysis pipelines to explore the impact of maternal perfluorohexanoic acid exposure in young mice o Characterized the transcriptional landscape of microglia in a mouse model of Fragile X syndrome o Provided surgical & imaging expertise to study the impact of pulmonary infection on neutrophil dynamics in the brain • Reviewer under Dr. Majewska’s guidance for grants and manuscripts submitted to Developmental Neurobiology, French National Research Agency, Cells, Current Biology, Brain Behavior and Immunity, Nature Neuroscience
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Bootcamp Committee
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Aug 2020 - Present
Orientation program for first-year graduate students of the Neuroscience Graduate Program • Organized, scheduled, and moderated 10-12 faculty research talks and 3-4 lab tours to present new graduate students with the breadth of current research in the department • Coordinated with other members to provide first-year students with 3-day orientation program including sessions on program and curriculum overview, mentorship, and meet & greet
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Research Mentor | Tutor | Teaching Assistant
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Aug 2020 - Present
Mentor undergraduate students: Nisha Arya (summer 2021); Abdirahman Diria (summer 2021), Kallam Kara-Pabani (2022-present). Under my mentorship, both Nisha and Kallam were the recipients of the UR Schwartz Discover Grant; and Kallam received both Dean’s Award and Makous Prize for his year-long project. Provide 1-1 tutor for graduate courses: Cellular Neuroscience & Neuroanatomy Teaching Assistant for: Foundations in Modern Biology I
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Neuroscience Graduate Program Retreat Committee
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Aug 2021 - Aug 2023
• Coordinated with other members to schedule student, faculty as well as key-note speakers • Promoted and encouraged fellow graduate students to present posters
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PONs, SfN Rochester Chapter
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Aug 2021 - Aug 2023
Pre-doctoral Organization for the Neurosciences, Society for Neuroscience Rochester Chapter • Planned and hosted one neuroscience-related roundtable discussion with scientists and medical professionals per academic semester on current topics in basic, applied, and translational neuroscience
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Graduate Intern
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Sep 2022 - Dec 2022
Advisor: Dr. Dalia Ghoneim • Trained in downstream analysis of RNA-sequencing and single-cell RNA-sequencing data • Performed first-pass analysis on multiple single-cell datasets to inform further investigation
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First-year Advising Committee
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Aug 2020 - May 2022
• Facilitated first-year students (2) transition to graduate school with monthly meetings • Provided prompt feedback on the student’s writing including rotation proposals and reports
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Fall 2019 Rotation
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Aug 2019 - May 2021
During my rotation in the Huxlin lab, my project helped to identify neuritogenic effects of inhibitors of mitochondrial pyruvate carrier using in vitro neuronal cell lines, implying potential benefits in recovery post-injury.
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Truman State University
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United States
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Higher Education
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700 & Above Employee
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Research Student
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Nov 2015 - Dec 2018
Studied neurodevelopment in Drosophila melanogaster (common fruit fly). Advisor: Dr. Brett A. Berke • Examined presynaptic growth at the neuromuscular junction (NMJ) of Drosophila 3rd instar larvae with manipulated postsynaptic phosphorylation/dephosphorylation activity • Responsible for laboratory inventory management
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Teaching Assistant
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Aug 2017 - May 2018
Teaching Assistant for: Neurobiology (BIOL518), Histology (BIOL309), and Physiology (BIOL315) Organized review sessions before exams, graded papers and tests for each course
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Event Committee, Vietnamese Student Association
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Aug 2015 - Dec 2016
Coordinated with other members to organize an annual outdoor dining event for ~200 students and faculty members to promote Vietnamese culture, as well as traditional holiday celebration for Vietnamese students on campus
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Public Relations, International Club
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Aug 2014 - Dec 2015
• Coordinated with other members to organize two annual major events: a talent show in the fall and an international cuisine night in the spring featuring students from around 10 different countries every year • Hosted events and regular meetings frequently to promote awareness on various international cultures
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Massachusetts General Hospital
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United States
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Hospitals and Health Care
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700 & Above Employee
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Research Intern
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Jun 2015 - Aug 2016
Interned at the laboratory of Dr. Vidal Melo for 2 summers (2015 and 2016), studying ventilation-induced lung injuries. • Quantified the global and regional respiratory mechanics dysfunction during robotic surgery at different levels of intensity of muscle paralysis; and drafted the introduction and results of the published manuscript • Assisted in preparation for measurements and collection of data in a study addressing potential intraoperative protective ventilation strategies to… Show more Interned at the laboratory of Dr. Vidal Melo for 2 summers (2015 and 2016), studying ventilation-induced lung injuries. • Quantified the global and regional respiratory mechanics dysfunction during robotic surgery at different levels of intensity of muscle paralysis; and drafted the introduction and results of the published manuscript • Assisted in preparation for measurements and collection of data in a study addressing potential intraoperative protective ventilation strategies to reduce risks of postoperative pulmonary complications Show less Interned at the laboratory of Dr. Vidal Melo for 2 summers (2015 and 2016), studying ventilation-induced lung injuries. • Quantified the global and regional respiratory mechanics dysfunction during robotic surgery at different levels of intensity of muscle paralysis; and drafted the introduction and results of the published manuscript • Assisted in preparation for measurements and collection of data in a study addressing potential intraoperative protective ventilation strategies to… Show more Interned at the laboratory of Dr. Vidal Melo for 2 summers (2015 and 2016), studying ventilation-induced lung injuries. • Quantified the global and regional respiratory mechanics dysfunction during robotic surgery at different levels of intensity of muscle paralysis; and drafted the introduction and results of the published manuscript • Assisted in preparation for measurements and collection of data in a study addressing potential intraoperative protective ventilation strategies to reduce risks of postoperative pulmonary complications Show less
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Công ty TNHH Quảng cáo Thương mại và công nghệp Hà Nội [English name: AIT Advertising company]
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617 Kim Ma, Ngọc Khanh, Ba Dinh District, Hanoi, Vietnam
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Public Relations Intern
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Jul 2014 - Aug 2014
Microsoft Lean Gallery Project • Promptly conveyed feedback from clients to facilitate effective communications between the designers and clients • Partook in reviewing various purchase documents and the record of handover Microsoft Lean Gallery Project • Promptly conveyed feedback from clients to facilitate effective communications between the designers and clients • Partook in reviewing various purchase documents and the record of handover
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External Relations Coordinator
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May 2014 - Aug 2014
• Partook in interview and selection of 20 students for a debate contest with about 400 audience members • Wrote and presented the program proposals with the committee to secure funding for the event • Partook in interview and selection of 20 students for a debate contest with about 400 audience members • Wrote and presented the program proposals with the committee to secure funding for the event
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Education
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University of Rochester School of Medicine and Dentistry
Doctor of Philosophy - PhD, Neuroscience -
Truman State University
Bachelor of Science (BS), Biology, General