Experience

Talus Bio
• United States
• Biotechnology Research
• 1 - 100 Employee
• Co-Founder and CTO

  • Oct 2020 - Present


University of Pennsylvania School of Medicine

• Higher Education
• 700 & Above Employee

• Postdoctoral Researcher

  • Sep 2019 - Jul 2021

  Postdoctoral research focuses on the roles of protein post-translational modifications (PTMs) and protein-protein interactions (PPI), especially in regulating an appropriate innate immune response. I am particularly interested in quantifying gene control proteins by mass spectrometry including histone modifications. My proposed work on protein-mediated shared and separate signaling across inflammation, cancer, and cellular senescence was recently supported by Penn’s NCI Training Program in Immunobiology of Normal and Neoplastic Lymphocytes, an institutional T32 mechanism. Show less



University of Washington

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • Sep 2014 - Aug 2019

  During my graduate career, my contributions focused on developing methods for mass spectrometry-based quantitative proteomics. I first worked on the development of data independent acquisition mass spectrometry (DIA-MS) methods make it possible to measure tens of thousands of peptides from a protein digest in two hours. I also introduced the need for reference materials in mass spectrometry proteomics, describing a simple strategy to calibrate using a reference sample, which places peptide and protein quantifications on the same scale and harmonizes quantities between different instruments, acquisition methods, and laboratories. Then, I extended my reference material calibration approach to show how not all peptides detected by MS are truly quantitative and showed that by assessing the quantitative proteome in yeast lysate, human cerebrospinal fluid, and formalin-fixed paraffin-embedded samples. In my methods development, I strive to make sure that my approaches are useful to and used by the community by making them simple to implement, agnostic to mass spectrometer hardware, and broadly generalizable across experimental systems. Show less



Broad Institute

• Research Services
• 700 & Above Employee

• Research Associate I

  • Sep 2011 - Jul 2014

  My contributions as a research associate were primarily in integrating novel accessories for mass spectrometry-based proteomics research. I worked independently on a device that separates peptides in a manner orthogonal to conventional liquid chromatography which I used to significantly reduce the length of MS-based methods to within clinical assay time limitations. I also worked collaboratively with a large team across multiple institutes to develop and optimize novel targeted quantitative assay for phosphorylated proteins implicated in cancer pathways. In that work, my role specifically was to build an automated sample preparation workflow using liquid handling robotics. Supervisors: Susan Abbatiello, PhD; Eric Kuhn Primary Investigator: Steve Carr, PhD (director, Proteomics Platform) Show less



Pennsylvania State University

• United States
• Higher Education
• 1 - 100 Employee

• Undergraduate Researcher

  • May 2008 - May 2009

  Supervisor: Melissa Rolls, PhDResearch: Neuron Microtubules--Gathered in vivo data on polarity of microtubule growth through confocal microscopy of GFP-tagged tubulin proteins in live Drosophila larvae neurons--Maintained lab’s Drosophila stocks and created new fly crosses to fulfill experimental designs

• Undergraduate Researcher

  • Jan 2006 - May 2008

  Supervisor: Emine Koc, PhDResearch: Mitochondrial Ribosome Proteins--Characterized mitochondrial ribosome protein L41 through chemical crosslinking assays, analysis by HPLC-MS, and database searches--Prepared weekly experimental samples including isolation of mitochondrial ribosomal proteins of interest from whole bovine liver



Wyeth Biopharma

• 1 - 100 Employee

• Intern - Quality Control Bioanalyst II

  • May 2007 - Aug 2007

  --Performed daily monitoring of system status through assays for total organic carbon (TOC), lactate dehydrogenase (LDH), and pH --Organized cGMP-regulation written reports on water systems and managed all departmental records and logbooks of paperwork --Performed daily monitoring of system status through assays for total organic carbon (TOC), lactate dehydrogenase (LDH), and pH --Organized cGMP-regulation written reports on water systems and managed all departmental records and logbooks of paperwork