Laxman Kasthoori
Sr. Executive at Sanzyme P LTD- Claim this Profile
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Bio
Experience
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Sanzyme P LTD
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India
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Pharmaceutical Manufacturing
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100 - 200 Employee
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Sr. Executive
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Mar 2023 - Present
Working in a biological laboratory, toxicology. Involved Bio-assay and in vivo studies. BIO_ASSAY@ Bioassays constitute a unique approach to determine the functional aspects of gonadotropins. Indeed, these highly complex glycoprotein hormones, including pituitary lutropin (LH) and follitropin (FSH), are heterogeneous in terms of both peptidic and carbohydrate moieties, and, as a consequence, the bioactivity of the different molecular forms often does not match their immunoreactivity. In this article, we review the different types of LH and FSH bioassays. Conventional methods for measuring FSH bioactivity are first described and include the in vivo Steelman and Pohley bioassay, the radioligand receptor assays (RRAs), the in vitro Sertoli cell bioassay, the in vitro granulosa cell bioassay, and the inhibin immunoassay. Recent methods based on cell lines transfected with cloned receptors, particularly the human FSH receptor, are then described. Methods for developing these assays are presented, and the advantages and disadvantages of the different bioassays are discussed. Show less
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Vimta Labs Ltd
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India
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Research Services
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700 & Above Employee
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Sr lab technician
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Nov 2015 - Sep 2022
*Sample collection *Hematology, Clinical chemistry, Coagulation, Urine analysis. *Data entry *QC Check *Instruments use, calibration, maintenance. ( GLP TEST FACILITY) *Sample collection *Hematology, Clinical chemistry, Coagulation, Urine analysis. *Data entry *QC Check *Instruments use, calibration, maintenance. ( GLP TEST FACILITY)
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