Lauren Hatfield, Ph.D.
Senior Scientist at Poseida Therapeutics, Inc.- Claim this Profile
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Bio
Experience
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Poseida Therapeutics, Inc.
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United States
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Biotechnology Research
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200 - 300 Employee
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Senior Scientist
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Feb 2023 - Present
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Scientist II
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Dec 2019 - Feb 2023
San Diego, California, United States CMC leader, driving cross-functional process development studies and technology transfer in support of Poseida's allogeneic cell therapy programs. Evaluates alternative technologies to create robust, scalable drug manufacturing processes. Develops platforms to streamline the generation of off-the-shelf allogeneic CAR-T products.
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University of Washington - School of Medicine
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United States
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Higher Education
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700 & Above Employee
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Graduate Student
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Oct 2013 - Mar 2019
Greater Seattle Area Ph.D. graduate from the Department of Immunology at the University of Washington School of Medicine. In the laboratory of Dr. Michael Gale, Jr., I investigated a non-canonical signaling pathway initiated by Interleukin-1 using in vitro and ex vivo infectious disease models, bioassays, systems immunology, CRISPR gene editing and functional analyses. We defined a mechanism of IL-1-induced cGAS and STING activation via the perturbation of mitochondrial dynamics that ultimately impacts the ability… Show more Ph.D. graduate from the Department of Immunology at the University of Washington School of Medicine. In the laboratory of Dr. Michael Gale, Jr., I investigated a non-canonical signaling pathway initiated by Interleukin-1 using in vitro and ex vivo infectious disease models, bioassays, systems immunology, CRISPR gene editing and functional analyses. We defined a mechanism of IL-1-induced cGAS and STING activation via the perturbation of mitochondrial dynamics that ultimately impacts the ability of myeloid and epithelial cells to recognize and initiate innate immune responses against microbial infection. Show less
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Scripps Research
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United States
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Research Services
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700 & Above Employee
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Research Assistant I
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Oct 2010 - Jul 2013
Greater San Diego Area In the laboratory of Dr. Daniel Salomon, in collaboration with Protein Structure Initiative: Biology and the Joint Center for Structural Genomics, mass spectrometry and sequencing techniques were developed to identify CD4+ T cell activation-dependent interactomes that drive alternative splicing and miRNA biogenesis.
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Scripps Research
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United States
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Research Services
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700 & Above Employee
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Summer Immunology and Virology Fellow
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Jun 2010 - Aug 2010
Greater San Diego Area In the laboratory of Dr. Michael Zwick, phage display libraries were constructed from broadly neutralizing HIV-seropositive bone marrow to isolate and clone high-affinity, HIV-neutralizing antibodies used to guide vaccine design and assist in structural studies of HIV envelope proteins.
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Research Intern
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Sep 2009 - Jun 2010
Greater San Diego Area In the laboratory of Dr. Julie Jameson, the epidermal tissues of gamma delta T cell-deficient and obese murine models were subjected to ex vivo histological and immunohistochemical analyses to determine structural and molecular differences that may play a role in dysfunctional wound healing.
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UC San Diego
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United States
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Higher Education
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700 & Above Employee
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Assistant III
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Apr 2008 - Jun 2010
Greater San Diego Area Provided organizational support for the library administrative staff of the Audrey Geisel Library. Responsibilities included the management of multiple University Librarian calendars, telephone support, and the maintenance of office documentation and filing systems.
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Education
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University of Washington
Doctor of Philosophy (Ph.D.), Immunology -
UC San Diego
B.S., Biochemistry and Cell Biology