Jonathan Larson

Founder & CTO, COO at Pulsar Bio
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Location
Tucson, Arizona, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Founder & CTO, COO
      • May 2020 - Sep 2023

      Watertown, Massachusetts, United States After seed-round fundraising, quickly transitioned Pulsar from a paper entity into a fully functional small R&D organization, achieving aggressive technical goals on schedule and within budget while team building, opening laboratory and office facilities, engaging professional business services, overseeing corporate finances, establishing EH&S protocols and systems, handling local safety regulation, and managing key strategic partnerships with world leaders in pharmacology.

    • Founder and CEO
      • Mar 2013 - Apr 2020

      Beverly, MA Pursuing the vision of painless early stage cancer screening, founded Lariat Biosciences and developed technologies specifically tailored for the challenge. In under three years, grew Lariat from its starting roots that consisted of only a vision, an empty lab bench, and a roll of laboratory tape into a small company, a self-sustaining operation. Combining various non-dilutive funding with a lean approach, maintained employee ownership while consistently achieving strategic milestones on… Show more Pursuing the vision of painless early stage cancer screening, founded Lariat Biosciences and developed technologies specifically tailored for the challenge. In under three years, grew Lariat from its starting roots that consisted of only a vision, an empty lab bench, and a roll of laboratory tape into a small company, a self-sustaining operation. Combining various non-dilutive funding with a lean approach, maintained employee ownership while consistently achieving strategic milestones on schedule and within budget. Accomplished Lariat’s primary technological goals, inventing Lariat’s signature droplet-based microfluidics with electronic detection and robust operation, as well as proprietary biochemical methods for allele-specific enrichment of mutant DNA related to cancer within hydrogel microparticles. Show less

    • VP, Research and Development
      • Mar 2012 - Sep 2012

      Cambridge, MA As a member of an early stage start-up company, automated a process for functionalizing hydrogel microparticles with a robotic liquid handler and developed a laboratory information management system (LIMS) to coordinate complicated inventory handling.

    • United States
    • Biotechnology
    • 1 - 100 Employee
    • Manager of Microfluidics
      • Mar 2008 - Feb 2012

      Lexington, MA Manager of droplet-based microfluidic techniques, directed the development of the commercial microfluidic chips for RainDance’s first three instrument platforms: RDT1000™, Thunderstorm™, and RainDrop™. Supervised the microfluidics team throughout each successful product cycle, with major highlights including improving chip reliability from 20% to >99%, porting designs from prototypes into high volume manufacturing materials, and managing joint development with outside… Show more Manager of droplet-based microfluidic techniques, directed the development of the commercial microfluidic chips for RainDance’s first three instrument platforms: RDT1000™, Thunderstorm™, and RainDrop™. Supervised the microfluidics team throughout each successful product cycle, with major highlights including improving chip reliability from 20% to >99%, porting designs from prototypes into high volume manufacturing materials, and managing joint development with outside vendors. Technical leader for the droplet digital PCR program, developed droplet digital PCR from the first proof-of-concept into the RainDrop product; managed a proof-of-performance study with a major outside molecular diagnostics company; broke the barrier of one target per color in quantitative PCR; invented novel DNA probe chemistries for high fluorescence gain; and achieved ultra-high, one-in-a-million specificity for the detection of rare genetic mutations related to cancer. Individual contributor, developed a fluorescence-assisted microdroplet sorter, requiring broad interdisciplinary integration of biochemistry, optics, microfluidics, software, electronics, and real-time microcontroller-based feedback control. Co-authored two high profile publications and four seminal patents. Show less

    • United States
    • Biotechnology
    • 1 - 100 Employee
    • Director, Lab-on-a-Chip Development
      • Mar 2001 - Mar 2008

      Woburn, MA Also, Staff Scientist (2001), Staff Scientist II (2003), Senior Scientist (2004), and Principal Investigator (2005) Directed the development of all lab-on-a-chip and single molecule detection methods, including the leadership of five small groups headed by Ph.D.-level science and engineering managers. Under a very aggressively scheduled biodefense program with the U.S. Department of Homeland Security, this organization consistently maintained all program milestones under budget.… Show more Also, Staff Scientist (2001), Staff Scientist II (2003), Senior Scientist (2004), and Principal Investigator (2005) Directed the development of all lab-on-a-chip and single molecule detection methods, including the leadership of five small groups headed by Ph.D.-level science and engineering managers. Under a very aggressively scheduled biodefense program with the U.S. Department of Homeland Security, this organization consistently maintained all program milestones under budget. Established and oversaw collaborations with three notable external research institutions. Co-authored five peer reviewed publications and six patent applications, one already awarded. Developed numerous scientific instruments for biophysical characterization and manipulation of single DNA molecules, and authored software for barcoding single DNA molecules that was once in use by over forty internal researchers and engineers. Show less

Education

  • University of Illinois at Urbana-Champaign
    Ph.D., Biophysical Chemistry
    1993 - 2000
  • St. Olaf College
    Bachelor of Arts (B.A.), Physics
    1989 - 1993

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