Experience

Calico Life Sciences

• United States
• Biotechnology Research
• 200 - 300 Employee

• Principal Scientist

  • Jan 2022 - Present

• Senior Scientist

  • Oct 2021 - Dec 2021

• Scientist II

  • Jul 2020 - Nov 2021

  Project leadership in drug discovery research toward identification of targets for aging and age-related diseases • Building and leading productive cross-functional collaborations focused on target discovery and validation • Areas of focus: metabolism, aging, immunology, cell biology, growth factor signaling • Responsibilities include: developing project strategies, integrating data, setting gates and overcoming project road blocks, experimentally and computationally contributing… Show more Project leadership in drug discovery research toward identification of targets for aging and age-related diseases • Building and leading productive cross-functional collaborations focused on target discovery and validation • Areas of focus: metabolism, aging, immunology, cell biology, growth factor signaling • Responsibilities include: developing project strategies, integrating data, setting gates and overcoming project road blocks, experimentally and computationally contributing to projects, presenting projects to senior leadership, engaging KOLs

• Scientist I

  • Jul 2017 - Jun 2020

  San Francisco Bay Area Basic research in aging biology and identification of drug targets for aging and age-related diseases Early stage drug discovery: • Target discovery and validation; due diligence; assay development; project design; cross-functional collaborations • Helped develop, organized and presented at a company-wide "AGING SEMINAR SERIES", a 3-month long course covering key areas of aging biology Basic research: • Basic research in _C. elegans_ to characterize and interpret gene… Show more Basic research in aging biology and identification of drug targets for aging and age-related diseases Early stage drug discovery: • Target discovery and validation; due diligence; assay development; project design; cross-functional collaborations • Helped develop, organized and presented at a company-wide "AGING SEMINAR SERIES", a 3-month long course covering key areas of aging biology Basic research: • Basic research in _C. elegans_ to characterize and interpret gene expression changes that occur during aging • Generated an open source web-interface for implementation of ICA-based gene expression modules for gene expression data analysis (Shiny App based): http://genemodules.org/

• Post-doctoral fellow

  • Aug 2015 - Jun 2017

  San Francisco Bay Area Basic research into genetics of aging, healthspan and gene x environment interactions



University of California, San Francisco

• United States
• Higher Education
• 700 & Above Employee

• Post-doctoral research associate

  • Nov 2014 - Jul 2015

  San Francisco Bay Area Applied high-content behavioral assays to better understand how pro-longevity genetic and environmental interventions affect healthspan and aging Advisor: Cynthia Kenyon



The Scripps Research Institute

• PhD Student (Immunology, Genomics and Systems biology)

  • Jun 2008 - Jun 2014

  Greater San Diego Area Designed and performed high throughput sequencing experiments to survey small RNA expression changes that occur during activation of human CD4 T cells; developed and implemented data analysis pipelines Identified microRNA gene targets in human CD4 T cells by conducting gain of function and genome-wide gene expression studies Characterized the mechanisms by which select microRNAs regulate activation of human CD4 T cells Discovered novel small RNA species that undergo… Show more Designed and performed high throughput sequencing experiments to survey small RNA expression changes that occur during activation of human CD4 T cells; developed and implemented data analysis pipelines Identified microRNA gene targets in human CD4 T cells by conducting gain of function and genome-wide gene expression studies Characterized the mechanisms by which select microRNAs regulate activation of human CD4 T cells Discovered novel small RNA species that undergo differential expression during T cell activation Characterized sensitivities of different human T cell subsets to clinically used immunosuppressant agents and conducted genome-wide gene expression studies to elucidate the underlying mechanisms Advisor: Late Professor Daniel R. Salomon Show less

• Research Technician, Havran lab

  • Sep 2006 - Jun 2007

  Greater San Diego Area Aided in the generation of a crystal structure for a monoclonal antibody against a γδT cell co-stimulatory molecule by cloning and sequencing the antibody cDNA sequence Helped characterize the role of a γδT cell co-receptor in epidermal wound repair by conducting in vivo and ex-vivo wound closure experiments

• Summer Undergraduate Research Fellow, Jameson lab

  • Jun 2006 - Aug 2006

  Greater San Diego Area Detected and quantified mTOR-mediated autophagy in epithelial γδT cells using fluorescent microscopy



UC Santa Barbara

• Higher Education
• 700 & Above Employee

• Teaching Assistant

  • Sep 2005 - Jun 2006

  Santa Barbara, California Area Conducted discussion sections for upper division protein biochemistry and immunology courses, graded exams and lab reports, conducted review sessions and held office hours. Conducted an upper division immunology laboratory course.

• Undergraduate Research Assistant, Sears Lab

  • Mar 2005 - Jun 2006

  Santa Barbara, California Area Helped characterize the role of the intracellular domain of the FcγRI receptor in phagocytosis by macrophages using molecular biology and flow cytometry