Jose Chavez Ph.D.
Scientist at Janssen Research & Development, LLC- Claim this Profile
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English Full professional proficiency
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Spanish Native or bilingual proficiency
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Bio
Credentials
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Financial Conflicts of Interest in Research
CITI ProgramJun, 2021- Oct, 2024
Experience
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Janssen Research & Development, LLC
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United States
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Pharmaceutical Manufacturing
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1 - 100 Employee
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Scientist
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May 2022 - Present
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Scientist and Research Faculty
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Oct 2018 - May 2022
- Engineered novel human cell lines using groundbreaking CRISPR/Cas9 technology to study the impact of specific mutations on the outcome of rare primary immunodeficiency diseases like WHIM Syndrome.- Developed assays to test the role of CXCR4 in immunodeficient patients to elucidate its mechanism of action in an immune response, currently being prepared for publication. - Demonstrated ability to multi-task and manage time efficiently between teaching responsibilities (in-person or remote) and performing lab duties to ensure project completion and on time submission of NIH grants. Show less
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Scientist and Project Manager
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Oct 2015 - Oct 2018
- Established novel human cell lines to study the role of Ligase I in DNA repair and immune response resulting in 1 peer reviewed publication.- Co-ordinated with multiple researchers and successfully executed project to study the role of Transmembrane Activator & CAML Interactor in lymphocyte development resulting in 2 peer reviewed publications.
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Immunology Institute. Icahn School of Medicine at Mount Sinai
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United States
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Research Services
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1 - 100 Employee
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Scientist and Project Manager:
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Jan 2013 - Apr 2015
- Oversaw scientists both in primary and collaborating labs and orchestrated timely completion of multiple projects involving the study of VDJ recombination - Headed a team of scientists from diverse backgrounds to study the role of novel phosphorylation sites on the regulation of LIG4 in non-homologous end joining resulting in 1 peer reviewed publication and a 2nd manuscript in preparation. - Executed project to study the role a novel mutation in Artemis (T65I) and its effect on Non-homologous End Joining resulting in 1 manuscript currently under review. Show less
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Icahn School of Medicine at Mount Sinai
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United States
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Hospitals and Health Care
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700 & Above Employee
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Scientist, Research Co-Ordinator and Lab Manager
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Aug 2005 - Jan 2012
- Developed multiple biochemical and molecular biology assays including experiments to identify protease cleavage sites on membrane protein targets resulting in 3 peer reviewed publications. - Designed and implemented multiple strategies including cloning, and expression systems in bacteria and yeast in order to maintain a pipeline for crystallization trials for quaternary structure of membrane proteins. - Supervised associate researchers and junior scientists with their projects and managed lab inventory, equipment maintenance and ensured proper abidance of lab safety rules. Show less
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Lehman College
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United States
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Higher Education
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1 - 100 Employee
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Adjunct Lecturer
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Jun 2006 - Jul 2009
Lecturing of the courses: Organic Chemistry and Biochemistry. Lecturing of the courses: Organic Chemistry and Biochemistry.
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City College of New York
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United States
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Higher Education
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1 - 100 Employee
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Adjunct Lecturer
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Jan 2003 - Sep 2007
Instructor in the laboratory of the Biochemistry course. Instructor in the laboratory of the Biochemistry course.
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Universidad Nacional Agraria La Molina
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Peru
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Higher Education
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700 & Above Employee
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Associate Professor
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Apr 1992 - Jan 2003
Lecturing of the courses: Biochemistry, Enzymology and Chemical and Enzymatic Kinetics. Lecturing of the courses: Biochemistry, Enzymology and Chemical and Enzymatic Kinetics.
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Universidad Nacional Mayor de San Marcos
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Peru
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Higher Education
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1 - 100 Employee
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Estudiante de Maestria en Bioquimica
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1990 - 1994
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Education
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City University of New York Graduate Center
M.Phil., Ph.D., Biochemistry -
Universidad Nacional Mayor de San Marcos
MgSc studies, Biochemistry -
Universidad Nacional Agraria La Molina
BS, Biology -
Universidad Peruana Cayetano Heredia
BS studies, Biology