Jonah Simon

Senior Scientist at Axial Therapeutics, Inc.
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Contact Information
Location
Boston, Massachusetts, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Senior Scientist
      • Jul 2022 - Aug 2023

    • Scientist
      • Jun 2021 - Jul 2022

    • Research Associate II
      • Dec 2018 - Jun 2021

    • Research Associate
      • Jul 2017 - Oct 2018
    • Spain
    • Technology, Information and Internet
    • 1 - 100 Employee
    • Volunteer
      • Jan 2017 - Jul 2017

      • Assist with conceptual product development and direction • Assist with practical tasks to spread DiscoveryEngine • Developed a plan to grow a loyal user base • Assist with conceptual product development and direction • Assist with practical tasks to spread DiscoveryEngine • Developed a plan to grow a loyal user base

    • Research Assistant
      • Nov 2014 - Jun 2017

      • Created a novel single-copy ALS model in C. elegans using CRISPR/Cas9 genome editing • Elucidated a molecular pathway connecting miRNA dysfunction to neuromuscular junction defects in a SMA model • Evaluated phenotypes of single-copy ALS models with a variety of behavioral, biochemical, and pharmacological assays • Created a novel single-copy ALS model in C. elegans using CRISPR/Cas9 genome editing • Elucidated a molecular pathway connecting miRNA dysfunction to neuromuscular junction defects in a SMA model • Evaluated phenotypes of single-copy ALS models with a variety of behavioral, biochemical, and pharmacological assays

    • United States
    • Research Services
    • 1 - 100 Employee
    • Oncology Intern
      • May 2015 - Aug 2015

      • Developed and validated a high-throughput imaging assay to quantify Alternative Lengthening of Telomeres activity based on a novel biomarker • Developed and optimized a protocol combining immunofluorescence and fluorescent in situ hybridization to detect protein-nucleotide interactions at telomeres • Developed and validated a high-throughput imaging assay to quantify Alternative Lengthening of Telomeres activity based on a novel biomarker • Developed and optimized a protocol combining immunofluorescence and fluorescent in situ hybridization to detect protein-nucleotide interactions at telomeres

    • South Africa
    • Wellness and Fitness Services
    • 1 - 100 Employee
    • Neurology Intern
      • May 2014 - Aug 2014

      • Optimized a high-content immunofluorescence assay to quantify stress granule dynamics in human cell lines • Characterized stress granule dynamics in response to a variety of cellular stresses and developed protocols for robust stress granule induction • Contributed to an exploratory project in target discovery • Optimized a high-content immunofluorescence assay to quantify stress granule dynamics in human cell lines • Characterized stress granule dynamics in response to a variety of cellular stresses and developed protocols for robust stress granule induction • Contributed to an exploratory project in target discovery

    • Research Assistant
      • Nov 2012 - Jun 2013

      • Cloned a gene for a voltage gated sodium channel subtype in P. terribilis • Identified mutation likely conferring batrachotoxin resistance • Cloned a gene for a voltage gated sodium channel subtype in P. terribilis • Identified mutation likely conferring batrachotoxin resistance

    • Singapore
    • Fisheries
    • 1 - 100 Employee
    • Food Runner; Busboy
      • Jun 2010 - Aug 2012

Education

  • Brown University
    Bachelor of Science - BS, Neuroscience
    2013 - 2017
  • Cambridge Rindge and Latin School
    High School Diploma
    2009 - 2013

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