Experience

Innovo Therapeutics
• United States
• Biotechnology Research
• 1 - 100 Employee
• Director

  • Jan 2023 - Present

Biotheryx, Inc.
• United States
• Biotechnology Research
• 1 - 100 Employee
• Sr. Principal Scientist

  • Apr 2022 - Jul 2022


Bristol Myers Squibb

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Principal Scientist

  • Apr 2021 - Mar 2022

  -As the Medicinal Chemistry and co-project lead to a CELMoD 'Molecular Glu' based protein homeostasis project, I have helped steer the project from hit to lead to short list candidacy. Responsibilities include designing and coordinating the synthesis of target analogs both internally and externally at CRO's, generating weekly queue lists for compounds to run in biological assays, and serving as the Chemistry representative and co-project lead to the Project Core Team. Additional responsibilities are to facilitate cross functional processes in expedient fashion in order to meet project transition goals. -I have designed, synthesized and characterized small molecules to help overcome adversity in potency, DMPK (stability and pk) and toxicology (hERG etc). Show less

• Senior Scientist

  • Sep 2020 - Apr 2021

  As the Medicinal Chemistry and co-project lead to a CELMoD 'Molecular Glu' based protein homeostasis project, I have helped steer the project from hit to lead to short list candidacy. Responsibilities include designing and coordinating the synthesis of target analogs both internally and externally at CRO's, generating weekly queue lists for compounds to run in biological assays, and serving as the Chemistry representative and co-project lead to the Project Core Team. Additional responsibilities were to facilitate cross functional processes in expedient fashion in order to meet project transition goals. Show less

• Scientist II

  • Nov 2019 - Sep 2020

  As the Medicinal Chemistry and co-project lead to a CELMoD 'Molecular Glu' based protein homeostasis project, I have helped steer the project from hit to lead to short list candidacy. Responsibilities include designing and coordinating the synthesis of target analogs both internally and externally at CRO's, generating weekly queue lists for compounds to run in biological assays, and serving as the Chemistry representative and co-project lead to the Project Core Team. Additional responsibilities were to facilitate cross functional processes in expedient fashion in order to meet project transition goals Show less



Celgene

• United States
• Pharmaceutical Manufacturing
• 700 & Above Employee

• Scientist II

  • Jan 2018 - Nov 2019

  -Chemistry project lead for a CelMOD molecular glu project in solid tumor oncology.-Designed and synthesized analogs for the AR (Androgen Receptor) PROTAC project. Design ideas led to the success in delivery of the IND candidate to the clinic while achieving project/site goals.-Contributed intellectually to an epigentic target utilizing a single molecule and/or protac modality . Ideas generated were critical for improved potencies and trajectories for PROTAC on the project.

• Scientist I

  • Mar 2013 - Jan 2018

  -Led medicinal chemistry efforts for a PROTAC project using external CRO resources to a No go decision point. -Setup screening triage for an Immuno-oncology target. Sourced and setup external expertise for screening campaign (Reporter and FRET assays at Orphagen). -Triaged multiple immuno-oncology targets as potential lead identification projects in the IO TcOE. -Led medicinal chemistry efforts for a kinase project where I designed and synthesized analogs with single digit nanomolar potency with extraordinary selectivity (2/256) against the kinome. These compounds have good DMPK properties (stability, clearance, oral exposure).-Assisted CRO with novel linkers for an ADC (antibody drug conjugate) program -Synthesized and purified short list inhibitors for the Imid-AML i.v. project with success within aggressive timeframes.-Designed, synthesized and purified small molecule inhibitors based on the SAR of the PKC-t and IRAK-4 enzymes.-Productive member of the PKCt team whose ideas have contributed towards a clinical candidate.-Chemistry coordinator for a kinase project . A detail oriented task that assures in house and/or CRO compound intermediates, in house/CRO scale ups, CRO evaluations, CRO synthesis are kept up to date without delays. Continuously provide detailed feedback/suggestions to CRO’s to assure chemistry is moving along smoothly. Show less

• Sr Associate Scientist

  • Mar 2010 - Mar 2013

  -Designed, synthesized and purified small molecule inhibitors around 2 kinase projects-Productive member of a kinase team whose ideas have led to novel series with good PK data which advanced to acute and chronic animal models.-Chemistry coordinator for a kinase project. A detail oriented task that assures in house and/or CRO compound intermediates, in house/CRO scale ups, CRO evaluations, CRO synthesis are kept up to date without delays. Continuously provide detailed feedback/suggestions to CRO’s to assure chemistry is moving along smoothly.-Provided detailed data analysis for the Tuberculosis project in Celgene’s Global Health Initiative using in house libraries. Headed numerous presentations and teleconferences to discuss this data to collaborators and Celgene Global Health leaders.-Designed novel analogs for a GPCR project while maintaining productivity on current projects.-Novel analog contributions (sustainability) which includes patentability outside of current projects increasing Celgene’s chemical file for future targets and/or fragment based drug design.-Designed novel templates and assisted with pharmacophore development for GPCR antagonist without the use of HTS.-Mentored junior chemists in analysis of SAR data and idea generation using software tools and qualitative analysis.-Productive member of the Syk team whose ideas assisted the preclinical development of a novel inhibitor. Show less

• Associate Scientist

  • Mar 2006 - Mar 2010

  -Designed and synthesized small molecule inhibitors based on SAR of PKC-t, mTOR, IKK, Syk and the IRAK-4. enzymes. -Productive team member of mTOR whose ideas assisted the development of a candidate in Phase I clinical trial.-Utilizing litereature, novel design ideas were generated to improve Celgene’s novel chemical file and for future fragment libraries.

• Senior Research Associate II

  • Nov 2003 - Mar 2006

  -Designed and synthesized small molecules used for biological evaluation (SAR)-Purified and characterized potent analogs for the inhibition of the JNK and Akt enzymes.

• Senior Research Associate I

  • Jan 2001 - Nov 2003

  -Purified and characterized compounds synthesized for a multiple kinase inhibition project (Mki)-Purified and characterized compounds synthesized for non-steroidal Selective Estrogen Receptor Ligands (Serm’s)-Developed synthesis of isoflavone core structure analogs for a patent backup series.-Setup and maintained Waters LCMS for medicinal chemistry group.



Signal Pharmaceuticals LLC

• United States
• Biotechnology Research

• Research Associate II

  • Aug 1999 - Jan 2001

  -Prepared novel small molecules used to inhibit the JNK-2 kinase. -Synthesized and characterized compounds for use in inhibiting the Serm-Beta kinase. -Prepared weekly presentations of tasks completed to team members. -Prepared novel small molecules used to inhibit the JNK-2 kinase. -Synthesized and characterized compounds for use in inhibiting the Serm-Beta kinase. -Prepared weekly presentations of tasks completed to team members.