John Martin
Senior Director, Platform Lead at Akouos- Claim this Profile
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Bio
Credentials
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Fermentation Technology
Massachusetts Institute of Technology (MIT)Jul, 2016- Nov, 2024
Experience
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Akouos
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United States
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Biotechnology
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1 - 100 Employee
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Senior Director, Platform Lead
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Sep 2021 - Present
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Sanofi
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France
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Pharmaceutical Manufacturing
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700 & Above Employee
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Head of Cell and Gene Therapy External Clinical Manufacturing
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Sep 2018 - Sep 2021
• Oversee cross-functional teams of SMEs to provide end-to-end technical and operational leadership for external cell and vector manufacturing and tech transfers. • Accountable for the GMP supply of pre-clinical and clinical candidates in support of early and late stage product development. • Responsible for managing strategic alliances with partner CMOs and industry collaborators. • As CMC Project Leader, responsible for strategy development, planning and… Show more • Oversee cross-functional teams of SMEs to provide end-to-end technical and operational leadership for external cell and vector manufacturing and tech transfers. • Accountable for the GMP supply of pre-clinical and clinical candidates in support of early and late stage product development. • Responsible for managing strategic alliances with partner CMOs and industry collaborators. • As CMC Project Leader, responsible for strategy development, planning and timely execution for AAV CMC related functions from candidate selection to commercial launch. • Participate in due diligence activities to assess the fit of potential manufacturing partners. • Oversee, empower and foster a team that monitors CMC milestones, supply chain, timelines and deliverables. • Communicate budget, status and risks to upper management.
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Senior Scientist
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Mar 2015 - Sep 2018
• Managed a group of scientists and engineers responsible for the development and optimization of robust vector production and purification processes for early stage clinical products • Practical knowledge of design space mapping, scale-down modeling and virus clearance studies
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Scientist
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2008 - Mar 2015
• Manage teams of scientists and associates in the isolation of producer cell clones for several clinical programs • Technical leader, clone isolation, for rAAV producer cell platform technology transfer between Genzyme and Targeted Genetics • Characterized the molecular processes underlying recombinant AAV replication and packaging
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Principal Research Associate
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1992 - 2008
• Established in-house capability of baculovirus and herpesvirus recombinant AAV production platforms. • Developed new methods for the scale-up, production and purification of adenovirus vectors. •Responsible for the cloning, production, purification, characterization, fill/finish, QC and shipment of adenovirus based gene therapy vectors for Genzyme and collaborators (research, non-clinical and clinical) • Wrote SOPs, batch records and development reports supporting vector production… Show more • Established in-house capability of baculovirus and herpesvirus recombinant AAV production platforms. • Developed new methods for the scale-up, production and purification of adenovirus vectors. •Responsible for the cloning, production, purification, characterization, fill/finish, QC and shipment of adenovirus based gene therapy vectors for Genzyme and collaborators (research, non-clinical and clinical) • Wrote SOPs, batch records and development reports supporting vector production methods.
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Education
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Harvard Extension School
Master of Liberal Arts (A.L.M.), Biology, General -
Saint Anselm College
Bachelor of Arts (B.A.), Biology, General