John Martin

Senior Director, Platform Lead at Akouos
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Contact Information
us****@****om
(386) 825-5501
Location
Greater Boston

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Credentials

  • Fermentation Technology
    Massachusetts Institute of Technology (MIT)
    Jul, 2016
    - Nov, 2024

Experience

    • United States
    • Biotechnology
    • 1 - 100 Employee
    • Senior Director, Platform Lead
      • Sep 2021 - Present

    • France
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • Head of Cell and Gene Therapy External Clinical Manufacturing
      • Sep 2018 - Sep 2021

      • Oversee cross-functional teams of SMEs to provide end-to-end technical and operational leadership for external cell and vector manufacturing and tech transfers. • Accountable for the GMP supply of pre-clinical and clinical candidates in support of early and late stage product development. • Responsible for managing strategic alliances with partner CMOs and industry collaborators. • As CMC Project Leader, responsible for strategy development, planning and… Show more • Oversee cross-functional teams of SMEs to provide end-to-end technical and operational leadership for external cell and vector manufacturing and tech transfers. • Accountable for the GMP supply of pre-clinical and clinical candidates in support of early and late stage product development. • Responsible for managing strategic alliances with partner CMOs and industry collaborators. • As CMC Project Leader, responsible for strategy development, planning and timely execution for AAV CMC related functions from candidate selection to commercial launch. • Participate in due diligence activities to assess the fit of potential manufacturing partners. • Oversee, empower and foster a team that monitors CMC milestones, supply chain, timelines and deliverables. • Communicate budget, status and risks to upper management.

    • Senior Scientist
      • Mar 2015 - Sep 2018

      • Managed a group of scientists and engineers responsible for the development and optimization of robust vector production and purification processes for early stage clinical products • Practical knowledge of design space mapping, scale-down modeling and virus clearance studies

    • Scientist
      • 2008 - Mar 2015

      • Manage teams of scientists and associates in the isolation of producer cell clones for several clinical programs • Technical leader, clone isolation, for rAAV producer cell platform technology transfer between Genzyme and Targeted Genetics • Characterized the molecular processes underlying recombinant AAV replication and packaging

    • Principal Research Associate
      • 1992 - 2008

      • Established in-house capability of baculovirus and herpesvirus recombinant AAV production platforms. • Developed new methods for the scale-up, production and purification of adenovirus vectors. •Responsible for the cloning, production, purification, characterization, fill/finish, QC and shipment of adenovirus based gene therapy vectors for Genzyme and collaborators (research, non-clinical and clinical) • Wrote SOPs, batch records and development reports supporting vector production… Show more • Established in-house capability of baculovirus and herpesvirus recombinant AAV production platforms. • Developed new methods for the scale-up, production and purification of adenovirus vectors. •Responsible for the cloning, production, purification, characterization, fill/finish, QC and shipment of adenovirus based gene therapy vectors for Genzyme and collaborators (research, non-clinical and clinical) • Wrote SOPs, batch records and development reports supporting vector production methods.

Education

  • Harvard Extension School
    Master of Liberal Arts (A.L.M.), Biology, General
    1998 - 2002
  • Saint Anselm College
    Bachelor of Arts (B.A.), Biology, General
    1988 - 1992

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