Experience

HistoGenetics
• United States
• Biotechnology Research
• 1 - 100 Employee
• Laboratory Assistant

  • Jul 2022 - Present


Anhui Heal Star Pharmaceutical Co., Ltd.

• Drug R&D Analyst

  • Jul 2017 - Sep 2018

  Established content determination method (HPLC) for API intermediate I-IV during R&D of pentazocine (Category II psychotropic drug) raw materials and preparations Developed detection method (atomic absorption +gas chromatography) for chemical residues in pentazocine preparations Established content determination method (HPLC) for API intermediate I-IV during R&D of pentazocine (Category II psychotropic drug) raw materials and preparations Developed detection method (atomic absorption +gas chromatography) for chemical residues in pentazocine preparations



安徽大学

• China

• Lab Associate

  • Dec 2016 - Feb 2018

  Lab of proteomics, Participated in the project: Structural and Biochemical Characterization of Lpg2622 Reveals a New Member of the C1 Family from Legionella Pneumophila, take part in a paper which had been published. Xiaojian Gong 1, Xiaolei Zhao 2, Wei Zhang 3, Jinzhao Wang4, ****. Structural characterization of the hypothetical protein Lpg2622, a new member of the C1 family peptidases from Legionella pneumophila. FEBS Lett, 2018, 592(16):2798-2810 Abstract: The Legionella pneumophila type II secretion system can promote bacterial growth under a wide variety of conditions and mediates the secretion of more than 25 proteins, including the uncharacterized effector Lpg2622. Here, we determined the crystal structures of apo‐Lpg2622 and Lpg2622 in complex with the cysteine protease inhibitor E64. Structural analysis suggests that Lpg2622 belongs to the C1 family peptidases. Interestingly, unlike the other structurally resolved papain‐like cysteine proteases, the propeptide of Lpg2622 forms a novel super‐secondary structural fold (hairpin‐turn‐helix) and can be categorized into a new group. In addition, the N‐terminal β‐sheet of the Lpg2622 propeptide plays a regulatory role on enzymatic activity. This study enhances our understanding of the classification and regulatory mechanisms of the C1 family peptidases. Show less