Experience

Bonumose Inc.
• Principal Scientist - Enzyme Development

  • May 2021 - Present


University of Virginia

• United States
• Higher Education
• 700 & Above Employee

• Research Scientist

  • Aug 2019 - May 2021

  • Researches for the molecular mechanisms for alloimmunization of Red blood cell (RBC) transfusion• Design, generate DNA constructs, and purify recombinant proteins for the analysis of RBC alloimmunization in mouse

• Research Scientist

  • May 2016 - Aug 2019

  • Developed and optimized High-Throughput Screening assay to discover the inhibitors of deubiquitinase DUB3 (Collaborative Research Agreement with National Center for Advancing Translational Sciences (NCATS-NIH)• Investigated the mechanism of action for novel pharmaceutical inhibitor of protein phosphatase 2A (PP2A) (Collaborative Research Agreement with Dual Therapeutics, LLC and Bristol-Myers Squibb)• Demonstrated that the phosphorylation of SAPS3 subunit by casein kinase-2 increases PP6 phosphatase activity for Aurora A kinase. (Biochem J. 2020;477(2):431)• Showed the selective toxicity of Caffeic acid in hepatocellular carcinoma cells (Biochem Biophys Res Commun. 2918;505(2):612)• Completed Mass-Spec Proteomics of LIM Domain 7 (LMO7, a.k.a. FBXO20) interactome (Nat. Commun. 2019;10(1):1117)• Studied phosphatases, PP2A and PP6, for protein interactions, drug sensitivity and resistance • Trained and supervised graduate students and research technicians Show less

• Research Associate

  • Jan 2014 - Apr 2016

  • Elucidated the role of Ubiquitin-Proteasome System in tumorigenesis (Semin Cancer Biol. 2016;36:33)• Demonstrated that previously known Cyclin D1 targeting ubiquitin ligase FBXO31 is irrelevant with Cyclin D1 level (In preparation)Trained and supervised graduate students and research technicians



University of Illinois at Chicago

• United States
• Higher Education
• 1 - 100 Employee

• Postdoctoral Research Associate

  • Sep 2010 - Dec 2013

  • Found Tyrosyl-DNA phosphodiesterase (TDP1) promotes assembly of Non-Homologous End Joining (NHEJ) protein complexes on DNA ends (DNA Repair. 2015;30:28) • Showed the short open reading frame (sORF)-encoded polypeptide MRI-2 physically interacts with the Ku heterodimer to stimulate DNA double strand break repair (J Biol Chem. 2014;289(16):10950) Trained and supervised graduate students and research technicians • Found Tyrosyl-DNA phosphodiesterase (TDP1) promotes assembly of Non-Homologous End Joining (NHEJ) protein complexes on DNA ends (DNA Repair. 2015;30:28) • Showed the short open reading frame (sORF)-encoded polypeptide MRI-2 physically interacts with the Ku heterodimer to stimulate DNA double strand break repair (J Biol Chem. 2014;289(16):10950) Trained and supervised graduate students and research technicians



University of Tennessee, Knoxville

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • Sep 2005 - Aug 2010

  • Performed the extensive functional analysis of human cytomegalovirus viral chemokines, vCXCL-1s, on human neutrophils and found that vCXCL-1s possess different levels of activity on human neutrophils (J Immunol. 2015;195(1):227) • Found there are 14 genetic groups of vCXCL-1 and they are not correlated with clinical outcomes (Virology. 2008;378(1):86) • Performed the extensive functional analysis of human cytomegalovirus viral chemokines, vCXCL-1s, on human neutrophils and found that vCXCL-1s possess different levels of activity on human neutrophils (J Immunol. 2015;195(1):227) • Found there are 14 genetic groups of vCXCL-1 and they are not correlated with clinical outcomes (Virology. 2008;378(1):86)



Korea Science and Engineering Foundation (KOSEF)

• Research assistant

  • Sep 2004 - Jul 2005

  • Performed a research on CO and Methanol oxidation of mycobacterium by gene manipulation and proteomics (J Bacteriol. 2003;185(1):142) • Performed a protein profiling of mycobacterium by 2-DE and MALDI mass spectrometry Found a new potential carbon assimilation pathway in mycobacterium by identification of HPS and MNO expressions in the methanol-utilizing mycobacterium • Performed a research on CO and Methanol oxidation of mycobacterium by gene manipulation and proteomics (J Bacteriol. 2003;185(1):142) • Performed a protein profiling of mycobacterium by 2-DE and MALDI mass spectrometry Found a new potential carbon assimilation pathway in mycobacterium by identification of HPS and MNO expressions in the methanol-utilizing mycobacterium