Jie Zhu

R&D and BD at Bota Biosciences
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Contact Information
us****@****om
(386) 825-5501
Location
Los Angeles Metropolitan Area

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Experience

    • United States
    • Biotechnology
    • 1 - 100 Employee
    • R&D and BD
      • Mar 2020 - Present

    • United States
    • Biotechnology Research
    • 700 & Above Employee
    • Business Development Consultant
      • Mar 2020 - Sep 2020

    • Organism Engineer
      • Oct 2017 - Mar 2020

      Greater Boston Area Biosynthesis of natural sweetener in yeast through large scale enzyme library screening • Characterized the biosynthetic pathway from plant and optimized the pathway in yeast • Identified the bottlenecks and solved the rate limiting step through HTP enzyme screening Optimization of automated genome engineering tools for yeast • Standardized the strain engineer process to accelerate the build and test of yeasts

    • United States
    • Biotechnology Research
    • 700 & Above Employee
    • Summer Internship
      • Jun 2017 - Sep 2017

      Emeryville, CA Metabolic engineering of natural sweetener biosynthesis in yeast through P450 engineering • Developed a HTP colorimetric assay to quantify P450 activity in vivo • Designed a platform for CPR biodiversity screen and promoter titration Development of a second switch for byproduct valorization • Characterized inducible systems compatible with preexisting switch for large scale production

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate student
      • Sep 2012 - Mar 2017

      Engineer volatile short and medium chain ester synthesis in microbial cell factories • Developed a rapid screening assay for alcohol acetyl/acyltransferase activity • Characterized the localization and trafficking mechanisms of ester synthase in S. cerevisiae • Improved short and medium chain volatile ester production in S. cerevisiae Control local substrate concentrations and enzyme kinetics through designed intermolecular interactions • Introduced new substrate-enzyme… Show more Engineer volatile short and medium chain ester synthesis in microbial cell factories • Developed a rapid screening assay for alcohol acetyl/acyltransferase activity • Characterized the localization and trafficking mechanisms of ester synthase in S. cerevisiae • Improved short and medium chain volatile ester production in S. cerevisiae Control local substrate concentrations and enzyme kinetics through designed intermolecular interactions • Introduced new substrate-enzyme interactions via enzyme-DNA nanostructures • Tuned enzyme kinetics through designing substrates and DNA binding interaction via AutoDock Show less

Education

  • University of California, Riverside
    Doctor of Philosophy (PhD), Biochemistry and Molecular Biology
    2012 - 2017
  • University of California, Riverside
    Master's degree, Biochemistry
    2012 - 2014
  • East China University of Science and Technology
    B.A., Biology/Biological Sciences, General
    2008 - 2012

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