Jie Zhu
R&D and BD at Bota Biosciences- Claim this Profile
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Bio
Experience
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Bota Biosciences
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United States
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Biotechnology
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1 - 100 Employee
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R&D and BD
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Mar 2020 - Present
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Ginkgo Bioworks, Inc.
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United States
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Biotechnology Research
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700 & Above Employee
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Business Development Consultant
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Mar 2020 - Sep 2020
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Organism Engineer
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Oct 2017 - Mar 2020
Greater Boston Area Biosynthesis of natural sweetener in yeast through large scale enzyme library screening • Characterized the biosynthetic pathway from plant and optimized the pathway in yeast • Identified the bottlenecks and solved the rate limiting step through HTP enzyme screening Optimization of automated genome engineering tools for yeast • Standardized the strain engineer process to accelerate the build and test of yeasts
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Amyris
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United States
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Biotechnology Research
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700 & Above Employee
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Summer Internship
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Jun 2017 - Sep 2017
Emeryville, CA Metabolic engineering of natural sweetener biosynthesis in yeast through P450 engineering • Developed a HTP colorimetric assay to quantify P450 activity in vivo • Designed a platform for CPR biodiversity screen and promoter titration Development of a second switch for byproduct valorization • Characterized inducible systems compatible with preexisting switch for large scale production
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University of California, Riverside
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United States
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Higher Education
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700 & Above Employee
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Graduate student
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Sep 2012 - Mar 2017
Engineer volatile short and medium chain ester synthesis in microbial cell factories • Developed a rapid screening assay for alcohol acetyl/acyltransferase activity • Characterized the localization and trafficking mechanisms of ester synthase in S. cerevisiae • Improved short and medium chain volatile ester production in S. cerevisiae Control local substrate concentrations and enzyme kinetics through designed intermolecular interactions • Introduced new substrate-enzyme… Show more Engineer volatile short and medium chain ester synthesis in microbial cell factories • Developed a rapid screening assay for alcohol acetyl/acyltransferase activity • Characterized the localization and trafficking mechanisms of ester synthase in S. cerevisiae • Improved short and medium chain volatile ester production in S. cerevisiae Control local substrate concentrations and enzyme kinetics through designed intermolecular interactions • Introduced new substrate-enzyme interactions via enzyme-DNA nanostructures • Tuned enzyme kinetics through designing substrates and DNA binding interaction via AutoDock Show less
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Education
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University of California, Riverside
Doctor of Philosophy (PhD), Biochemistry and Molecular Biology -
University of California, Riverside
Master's degree, Biochemistry -
East China University of Science and Technology
B.A., Biology/Biological Sciences, General