Experience

New York Medicine Jobs

• Higher Education
• 100 - 200 Employee

• Senior Research Scientist

  • Feb 2022 - Present

• Research Scientist

  • Jun 2019 - Present

  As a research scientist, I established or confirmed new assays for our lab. I developed new research projects and drafted manuscripts. At the same time, I prepared documents, such as SOP, instruction, index and records; and organized the lab, such as equipment calibration, chemical storage, specimens inventory of the bio-bank, etc. for CAP inspection and IBBL certificates. I also managed the BSL 2+ lab. *Extract DNA/RNA from various clinical specimens, and prepare for IBBL (Integrated… Show more As a research scientist, I established or confirmed new assays for our lab. I developed new research projects and drafted manuscripts. At the same time, I prepared documents, such as SOP, instruction, index and records; and organized the lab, such as equipment calibration, chemical storage, specimens inventory of the bio-bank, etc. for CAP inspection and IBBL certificates. I also managed the BSL 2+ lab. *Extract DNA/RNA from various clinical specimens, and prepare for IBBL (Integrated Biobank of Luxembourg) certificates with QIAsymphony or KingFisher Apex. *Manage COVID-19 blood samples *Assist to prepare for the CAP (The College of American Pathologists) inspection • Culture spheroids of cancer cells • Image cells and spheroid with High-Content Screening Platform CellInsight CX7 • Analyze oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells by Seahorse XF Analyzers • Reverse transfection of SiRNA • ELISA (400 samples/day) • Liquid Handling, such as Biotek and Wellmate



University of Oklahoma

• United States
• Higher Education
• 700 & Above Employee

• Research Assistant Professor

  • Apr 2016 - Jun 2019

  As a Research Assistant Professor, I established some new bio-assays to expand the research area for our lab. As a leader of fungi natural product library team, I optimized the work flow, assigned the jobs and overseen the process to guarantee the goal could be achieved in time as contract. • Developed the cell-based assays and discovered several novel compounds against drug resistant fungi. Evaluated the activities of the hits in vitro (MIC, IC50) and in vivo. Investigated the mode of… Show more As a Research Assistant Professor, I established some new bio-assays to expand the research area for our lab. As a leader of fungi natural product library team, I optimized the work flow, assigned the jobs and overseen the process to guarantee the goal could be achieved in time as contract. • Developed the cell-based assays and discovered several novel compounds against drug resistant fungi. Evaluated the activities of the hits in vitro (MIC, IC50) and in vivo. Investigated the mode of action of active compounds by using LC-MS and HPLC. • Evaluated the activities of a series of novel antibiotics against drug resistant bacteria. • Developed cell-based anti-tuberculosis assay. • Explored the mechanism of action of a novel anti-cancer peptide by using atomic force microscope (Asylum Research). • Created a novel platform to explore the compounds’ synergistic activities against Gram-negative bacteria. • Made 75 artworks by culturing various fungi on felt for Science Museum Oklahoma to exhibit the beautiful fungi from The University of Oklahoma Citizen Science Soil Collection Program. Lab manager and team leader • Supervised a team (> five people) to build a microorganism library (4 000 unique strains per year) and a natural product library (12 000 extracts per year), and increased the productivity by up to 60% within 3 months by optimizing the workflow. • Assisted the supervisor to prepare grant proposals. • Mentored and trained 1 postdoctoral associate, 2 research associates, 9 graduate students and 5 undergraduate students in bioassay developments (anti-fungus, anti-bacteria, anti-biofilm, wax worm model and nematode model), fermentation (bioreactor and hollow fiber bioreactor), biotransformation, molecular biology techniques (DNA extraction, PCR, transfection, clone construction, SDS-PAGE), microorganism isolation and identification.

• Postdoctoral Research Assoc

  • Jan 2011 - Apr 2016

  As a postdoctoral fellow in OU, my research focused on discovering anti-bioflim compounds. Besides experiment design and bio-assay development, I drafted manuscripts and created new ideas for funding application. • Created the novel anti-fungal biofilm assays to discover the target specific fungal biofilm inhibitors and developed the synergistic combinations with clinical anti-fungal medicines by using the high-content imaging system (Operetta). • Investigated the mode of action by… Show more As a postdoctoral fellow in OU, my research focused on discovering anti-bioflim compounds. Besides experiment design and bio-assay development, I drafted manuscripts and created new ideas for funding application. • Created the novel anti-fungal biofilm assays to discover the target specific fungal biofilm inhibitors and developed the synergistic combinations with clinical anti-fungal medicines by using the high-content imaging system (Operetta). • Investigated the mode of action by using confocal laser scanning microscopy (Leica) and imaging flow-cytometry (Amnis FlowSight). • Designed and developed the new methods to culture the uncultured bacteria from environment by electroporation transformation or conjugation in situ. Lab manager • Mentored and trained over 30 graduate students and technicians in bio-assay operation, cell culture, PCR, RT-PCR, transfection, mini-animal model and fermentation. • Managed the flow of the day-to-day operations and the project budget. • Wrote the SOPs for the instruments and the lab operations. • Assisted in the preparation of grant proposals.



Guangzhou Institutes of Biomedicine and Health

• Biotechnology Research
• 1 - 100 Employee

• Scientist

  • Oct 2005 - Dec 2010

  As a scientist, my research focused on anti-cancer and anti-infection drug discovery. I designed and did experiment for my own projects, including bio-assay development, activity evaluation and mechanism discovery. I applied funding, published papers and patents as well. As a team leader, I provided training for graduate students, meanwhile I reviewed, organized and reported the data to our collaborators. • Established bioassays (cell-based or enzyme-based) to discover the new… Show more As a scientist, my research focused on anti-cancer and anti-infection drug discovery. I designed and did experiment for my own projects, including bio-assay development, activity evaluation and mechanism discovery. I applied funding, published papers and patents as well. As a team leader, I provided training for graduate students, meanwhile I reviewed, organized and reported the data to our collaborators. • Established bioassays (cell-based or enzyme-based) to discover the new therapeutic approaches for infectious diseases (HIV, fungi, bacteria and malaria) and cancer. • Investigated the mode of action of the anti-cancer and anti-HIV compounds by using Q-PCR, ELISA and western-blot. • Investigated the co-infection of malaria and tuberculosis in mouse model, including survival rate, pathogen loads in blood and different organs (lung, liver and kidney), and histological sections. • Explored the interactions of tuberculosis and acquired immune deficiency syndrome in monkey (Macaca mulatta) model by observing symptoms, pathogen load (Q-PCR and ELISA), the change of immune cells (CD3/4/8 cells and Treg cell by using flow cytometer and ELISA) and histological sections. Leader of drug discovery team and co-infection team • Supervised a drug discovery team to screen and evaluate the activity of novel compounds from our collaborators to discover anti-cancer, anti-HIV and anti-malaria, including creating SOP and plan, reviewing and summarizing data, and presenting results to our collaborators. • Monitored the project cost, recruited the internal and external collaborations, applied the funding, provided the training in bio-assay developments, small animal model and cell biology techniques. • Initialized and established the cooperation with three academic groups in China and two groups from the USA. • Applied for and received two research grants as a principal investigator from Guangdong Province and the Doctoral Program of Higher Education of China. Show less As a scientist, my research focused on anti-cancer and anti-infection drug discovery. I designed and did experiment for my own projects, including bio-assay development, activity evaluation and mechanism discovery. I applied funding, published papers and patents as well. As a team leader, I provided training for graduate students, meanwhile I reviewed, organized and reported the data to our collaborators. • Established bioassays (cell-based or enzyme-based) to discover the new… Show more As a scientist, my research focused on anti-cancer and anti-infection drug discovery. I designed and did experiment for my own projects, including bio-assay development, activity evaluation and mechanism discovery. I applied funding, published papers and patents as well. As a team leader, I provided training for graduate students, meanwhile I reviewed, organized and reported the data to our collaborators. • Established bioassays (cell-based or enzyme-based) to discover the new therapeutic approaches for infectious diseases (HIV, fungi, bacteria and malaria) and cancer. • Investigated the mode of action of the anti-cancer and anti-HIV compounds by using Q-PCR, ELISA and western-blot. • Investigated the co-infection of malaria and tuberculosis in mouse model, including survival rate, pathogen loads in blood and different organs (lung, liver and kidney), and histological sections. • Explored the interactions of tuberculosis and acquired immune deficiency syndrome in monkey (Macaca mulatta) model by observing symptoms, pathogen load (Q-PCR and ELISA), the change of immune cells (CD3/4/8 cells and Treg cell by using flow cytometer and ELISA) and histological sections. Leader of drug discovery team and co-infection team • Supervised a drug discovery team to screen and evaluate the activity of novel compounds from our collaborators to discover anti-cancer, anti-HIV and anti-malaria, including creating SOP and plan, reviewing and summarizing data, and presenting results to our collaborators. • Monitored the project cost, recruited the internal and external collaborations, applied the funding, provided the training in bio-assay developments, small animal model and cell biology techniques. • Initialized and established the cooperation with three academic groups in China and two groups from the USA. • Applied for and received two research grants as a principal investigator from Guangdong Province and the Doctoral Program of Higher Education of China. Show less



Guangzhou Baidi bio Pharmaceutical Co., Ltd

• Guangzhou, Guangdong, China

• R&D Project Manager

  • Jul 2005 - Oct 2005

  Guangzhou Baidi bio Pharmaceutical Co., Ltd was established in 2001. It is a holding subsidiary of Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd (600332.SS). • Reviewed and assessed the new drug development projects from Europe, USA and Australia. • Provided the investment suggestions. • Prepared the documents for new drug application of a protein therapeutics drug (recombinant Human granulocyte macrophage colony-stimulating factor, rhGM-CSF) to China Food and Drug… Show more Guangzhou Baidi bio Pharmaceutical Co., Ltd was established in 2001. It is a holding subsidiary of Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd (600332.SS). • Reviewed and assessed the new drug development projects from Europe, USA and Australia. • Provided the investment suggestions. • Prepared the documents for new drug application of a protein therapeutics drug (recombinant Human granulocyte macrophage colony-stimulating factor, rhGM-CSF) to China Food and Drug Administration (CFDA). • Good manufacturing practice (GMP) training. Show less Guangzhou Baidi bio Pharmaceutical Co., Ltd was established in 2001. It is a holding subsidiary of Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd (600332.SS). • Reviewed and assessed the new drug development projects from Europe, USA and Australia. • Provided the investment suggestions. • Prepared the documents for new drug application of a protein therapeutics drug (recombinant Human granulocyte macrophage colony-stimulating factor, rhGM-CSF) to China Food and Drug… Show more Guangzhou Baidi bio Pharmaceutical Co., Ltd was established in 2001. It is a holding subsidiary of Guangzhou Baiyunshan Pharmaceutical Holdings Co Ltd (600332.SS). • Reviewed and assessed the new drug development projects from Europe, USA and Australia. • Provided the investment suggestions. • Prepared the documents for new drug application of a protein therapeutics drug (recombinant Human granulocyte macrophage colony-stimulating factor, rhGM-CSF) to China Food and Drug Administration (CFDA). • Good manufacturing practice (GMP) training. Show less



Sun Yat-sen University

• Research
• 500 - 600 Employee

• Graduate Research Associate

  • Sep 2000 - Jun 2005

  • Isolated over 500 fungi and actinomycetes from various environment samples, such as deep sea sediments, mangrove, fish farm, soil and plant. • Established high throughput screening bio-assay to evaluate the activity of actinomycetes against Vibrio biofilm and created a novel simple assay to validate the activity. • Investigated the mode of action of anti-biofilm extract with Quorum Sensing assay. • Identified a novel siderophore related protein in Vibrio by using two-dimensional… Show more • Isolated over 500 fungi and actinomycetes from various environment samples, such as deep sea sediments, mangrove, fish farm, soil and plant. • Established high throughput screening bio-assay to evaluate the activity of actinomycetes against Vibrio biofilm and created a novel simple assay to validate the activity. • Investigated the mode of action of anti-biofilm extract with Quorum Sensing assay. • Identified a novel siderophore related protein in Vibrio by using two-dimensional polyacrylamide gel electrophpresis and MALDI-TOF-MS. Graduate Research Associate • Coached 5 undergraduate students in microbiology and molecular biology techniques. Show less • Isolated over 500 fungi and actinomycetes from various environment samples, such as deep sea sediments, mangrove, fish farm, soil and plant. • Established high throughput screening bio-assay to evaluate the activity of actinomycetes against Vibrio biofilm and created a novel simple assay to validate the activity. • Investigated the mode of action of anti-biofilm extract with Quorum Sensing assay. • Identified a novel siderophore related protein in Vibrio by using two-dimensional… Show more • Isolated over 500 fungi and actinomycetes from various environment samples, such as deep sea sediments, mangrove, fish farm, soil and plant. • Established high throughput screening bio-assay to evaluate the activity of actinomycetes against Vibrio biofilm and created a novel simple assay to validate the activity. • Investigated the mode of action of anti-biofilm extract with Quorum Sensing assay. • Identified a novel siderophore related protein in Vibrio by using two-dimensional polyacrylamide gel electrophpresis and MALDI-TOF-MS. Graduate Research Associate • Coached 5 undergraduate students in microbiology and molecular biology techniques. Show less