Jia Wei Chen

Data Scientist at Rubius Therapeutics
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Contact Information
us****@****om
(386) 825-5501
Location
Quincy, Massachusetts, United States, US

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Experience

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Data Scientist
      • Nov 2021 - Present

    • Data Associate
      • Jan 2020 - Nov 2021

    • United States
    • Biotechnology Research
    • 1 - 100 Employee
    • Data Associate
      • Jun 2013 - Jan 2020

      LIMS administrator for Analytical Development (AD) and Bio-process Development (BPD) sample and test registration. Administrator for LIMS assays, modules and infrastructure building, which serve as the fundamental of the AD LIMS system. Actively communicate with scientists and research associates the requirements and parameters for infrastructure building. Actively engage in the merger and harmonization of CMO data into internal data depository. This allow efficient data query for… Show more LIMS administrator for Analytical Development (AD) and Bio-process Development (BPD) sample and test registration. Administrator for LIMS assays, modules and infrastructure building, which serve as the fundamental of the AD LIMS system. Actively communicate with scientists and research associates the requirements and parameters for infrastructure building. Actively engage in the merger and harmonization of CMO data into internal data depository. This allow efficient data query for reporting and project management. Proficient in TIBCO Spotfire functionality in building modules for data extraction, calculations, statistical analysis, summary and visualization. Expert in using Spotfire in reporting metrics, inventory status and query. The dashboards provide higher management with timely program summary and greatly reduce the effort for manual data manipulation. Support data composition, compilation, review and audit for internal reports and FDA/EMEA filing. This supports Quality Assurance/GXP compliance/regulatory and potential launch of drug candidate. Collaborate with Quality Assurance, Metrology and vendors to ensure equipment qualification, validation and calibration in Analytical Development are within specification and regulation. Wrote Standard Operating Procedures, Guidance and Department Training Docutments under company policy. Work closely with QA and AD personnel to resolve deviation, investigation, CAPAs and Change Control. Show less LIMS administrator for Analytical Development (AD) and Bio-process Development (BPD) sample and test registration. Administrator for LIMS assays, modules and infrastructure building, which serve as the fundamental of the AD LIMS system. Actively communicate with scientists and research associates the requirements and parameters for infrastructure building. Actively engage in the merger and harmonization of CMO data into internal data depository. This allow efficient data query for… Show more LIMS administrator for Analytical Development (AD) and Bio-process Development (BPD) sample and test registration. Administrator for LIMS assays, modules and infrastructure building, which serve as the fundamental of the AD LIMS system. Actively communicate with scientists and research associates the requirements and parameters for infrastructure building. Actively engage in the merger and harmonization of CMO data into internal data depository. This allow efficient data query for reporting and project management. Proficient in TIBCO Spotfire functionality in building modules for data extraction, calculations, statistical analysis, summary and visualization. Expert in using Spotfire in reporting metrics, inventory status and query. The dashboards provide higher management with timely program summary and greatly reduce the effort for manual data manipulation. Support data composition, compilation, review and audit for internal reports and FDA/EMEA filing. This supports Quality Assurance/GXP compliance/regulatory and potential launch of drug candidate. Collaborate with Quality Assurance, Metrology and vendors to ensure equipment qualification, validation and calibration in Analytical Development are within specification and regulation. Wrote Standard Operating Procedures, Guidance and Department Training Docutments under company policy. Work closely with QA and AD personnel to resolve deviation, investigation, CAPAs and Change Control. Show less

  • The Broad Institute
    • Cambridge, USA
    • Research Associate I
      • Oct 2012 - Mar 2013

      Skilled in mammalian cell culture including cryopreservation, thawing, passaging and plating cells. Proficient in multiple cell based and biochemical assay includes but not limit to the following. ○ Support High-Throughput Screening and small scale secondary assays for hit validation ○ Execute qPCR, Luciferase gene reporter, Alpha Screen, Thermal Shift , and Cytotoxicity assays Competent at operation multiple laboratory equipment include but not limit to the following. Pinning… Show more Skilled in mammalian cell culture including cryopreservation, thawing, passaging and plating cells. Proficient in multiple cell based and biochemical assay includes but not limit to the following. ○ Support High-Throughput Screening and small scale secondary assays for hit validation ○ Execute qPCR, Luciferase gene reporter, Alpha Screen, Thermal Shift , and Cytotoxicity assays Competent at operation multiple laboratory equipment include but not limit to the following. Pinning compounds with CyBio Well ○ qPCR with Veriti 384 Well Thermal Cycler and LightCycler 480 II ○ Laboratory Automation with ACell and NanoServe ○ Liquid handing with CyBi-Well Vario, BioRapter, Multidrop Combi and Multidrop Combi nL ○ Plate Washing with Bio-Tek ELx405 HT ○ Quantifying assay signal with EnVision 2102 Multilabel Reader ○ Cell counting with Cellometer Auto T4 and Mini Cell Counter Highly involved in data automation processing and cell base assay automation. Show less Skilled in mammalian cell culture including cryopreservation, thawing, passaging and plating cells. Proficient in multiple cell based and biochemical assay includes but not limit to the following. ○ Support High-Throughput Screening and small scale secondary assays for hit validation ○ Execute qPCR, Luciferase gene reporter, Alpha Screen, Thermal Shift , and Cytotoxicity assays Competent at operation multiple laboratory equipment include but not limit to the following. Pinning… Show more Skilled in mammalian cell culture including cryopreservation, thawing, passaging and plating cells. Proficient in multiple cell based and biochemical assay includes but not limit to the following. ○ Support High-Throughput Screening and small scale secondary assays for hit validation ○ Execute qPCR, Luciferase gene reporter, Alpha Screen, Thermal Shift , and Cytotoxicity assays Competent at operation multiple laboratory equipment include but not limit to the following. Pinning compounds with CyBio Well ○ qPCR with Veriti 384 Well Thermal Cycler and LightCycler 480 II ○ Laboratory Automation with ACell and NanoServe ○ Liquid handing with CyBi-Well Vario, BioRapter, Multidrop Combi and Multidrop Combi nL ○ Plate Washing with Bio-Tek ELx405 HT ○ Quantifying assay signal with EnVision 2102 Multilabel Reader ○ Cell counting with Cellometer Auto T4 and Mini Cell Counter Highly involved in data automation processing and cell base assay automation. Show less

    • Independent Study
      • Sep 2011 - May 2012

      Studied the impact of cranberry bioactive component on adipocyte differentiation Identified the molecular pathways involved and change in adipogenesis due to the impact Used PCR to identify specific gene marker associated with adipogenesis Developed presentation and interpersonal skills Studied the impact of cranberry bioactive component on adipocyte differentiation Identified the molecular pathways involved and change in adipogenesis due to the impact Used PCR to identify specific gene marker associated with adipogenesis Developed presentation and interpersonal skills

    • Research Assistant
      • Sep 2011 - May 2012

      Prepared analytical standards Developed drug compound isolation via HPLC and LCMS Interpreted sample chromatograms with MassLynx Prepared analytical standards Developed drug compound isolation via HPLC and LCMS Interpreted sample chromatograms with MassLynx

    • Lab Assistant
      • Sep 2010 - May 2011

      Trained on proper handling procedures for reagents and glassware as well as laboratory and workplace safety procedures for biohazards Prepared buffer and growth media and agarose and polyacrylamide (sequencing) gels Trained on proper handling procedures for reagents and glassware as well as laboratory and workplace safety procedures for biohazards Prepared buffer and growth media and agarose and polyacrylamide (sequencing) gels

    • Summer Internship
      • Jun 2010 - Aug 2010

      Trained in proper operation of analytical instrumentation Prepared standards and generated calibration curves Performed Bradford Protein Assay Carried out proper quality assurance protocols and requirements Extracted genomic and plasmid DNA Performed endonuclease restriction digestion and ligation on plasmid Trained in proper operation of analytical instrumentation Prepared standards and generated calibration curves Performed Bradford Protein Assay Carried out proper quality assurance protocols and requirements Extracted genomic and plasmid DNA Performed endonuclease restriction digestion and ligation on plasmid

Education

  • University of Massachusetts Boston
    Master of Science - MS, Business Analytics
  • University of Massachusetts Boston
    Master of Business Administration - MBA
  • University of Massachusetts, Amherst
    Bachelor's degree, Biochemistry and Molecular Biology, Chemistry
  • University of Massachusetts Amherst
    Bachelor's degree, Microbiology
  • University of Massachusetts Amherst
    Certification, Biotechnology

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