Experience

Peking University Health Science Center

• Higher Education
• 1 - 100 Employee

• Tenure-Track Assistant Professor

  • Nov 2022 - Present

  My lab selects and studies biostable L-DNA aptamers with particular focus on selection methods and L-DNA chemistry. My lab selects and studies biostable L-DNA aptamers with particular focus on selection methods and L-DNA chemistry.



Tsinghua University

• China
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • Sep 2016 - Aug 2022

  Developing new technologies to enable unnatural peptide aptamer and mirror-image DNA aptamer selection. Developing new technologies to enable unnatural peptide aptamer and mirror-image DNA aptamer selection.



National Center of Biomedical Analysis

• Beijing, China

• Postdoctoral Associate

  • Mar 2016 - Aug 2016



Purdue University

• United States
• Higher Education
• 700 & Above Employee

• Graduate Research Assistant

  • May 2011 - Feb 2016

  I have been working on three different research projects in Dr. Barb Golden's lab at Purdue University. First, I elucidiated the catalytic mechanism of the hepatitis delta virus (HDV) ribozyme by identifying an essential catalytic metal ion inside the active site of the ribozyme (Chen et al., 2013, Biochemistry 52: 557-567). I also played a major role in elucidating the catalytic mechanism of a prototype ribozyme (i.e. the hammerhead ribozyme), where I crystallized a new hammerhead ribozyme… Show more I have been working on three different research projects in Dr. Barb Golden's lab at Purdue University. First, I elucidiated the catalytic mechanism of the hepatitis delta virus (HDV) ribozyme by identifying an essential catalytic metal ion inside the active site of the ribozyme (Chen et al., 2013, Biochemistry 52: 557-567). I also played a major role in elucidating the catalytic mechanism of a prototype ribozyme (i.e. the hammerhead ribozyme), where I crystallized a new hammerhead ribozyme specieis and solved its structure. I performed a series of metal-soaking experiments and used X-ray anomalous scattering to first visualize a possible catalytic divalent metal ion binding pocket near the active site of the hammerhead. For my third project, I made a transition from mechanistic studies to synthetic biology. I designed and optimized an artificial RNA which could be used for incorporating a wide variety of unnatural amino acids into eukaryotic cells. Show less I have been working on three different research projects in Dr. Barb Golden's lab at Purdue University. First, I elucidiated the catalytic mechanism of the hepatitis delta virus (HDV) ribozyme by identifying an essential catalytic metal ion inside the active site of the ribozyme (Chen et al., 2013, Biochemistry 52: 557-567). I also played a major role in elucidating the catalytic mechanism of a prototype ribozyme (i.e. the hammerhead ribozyme), where I crystallized a new hammerhead ribozyme… Show more I have been working on three different research projects in Dr. Barb Golden's lab at Purdue University. First, I elucidiated the catalytic mechanism of the hepatitis delta virus (HDV) ribozyme by identifying an essential catalytic metal ion inside the active site of the ribozyme (Chen et al., 2013, Biochemistry 52: 557-567). I also played a major role in elucidating the catalytic mechanism of a prototype ribozyme (i.e. the hammerhead ribozyme), where I crystallized a new hammerhead ribozyme specieis and solved its structure. I performed a series of metal-soaking experiments and used X-ray anomalous scattering to first visualize a possible catalytic divalent metal ion binding pocket near the active site of the hammerhead. For my third project, I made a transition from mechanistic studies to synthetic biology. I designed and optimized an artificial RNA which could be used for incorporating a wide variety of unnatural amino acids into eukaryotic cells. Show less



Tsinghua University

• China
• Higher Education
• 700 & Above Employee

• Undergraduate Research Assistant

  • Jul 2007 - Dec 2009

  Working together with a senior graduate student in Laboratory of Structural Biology led by Professor Zihe Rao at Tsinghua, I expressed and purified several disease-related viral proteins (e.g. HIV integrase, protease, etc.) for X-ray crystallography studies. I also helped develop high-throughput screening assays based on ELISA for testing the inhibitory effect of a library of drug-like molecules. Working together with a senior graduate student in Laboratory of Structural Biology led by Professor Zihe Rao at Tsinghua, I expressed and purified several disease-related viral proteins (e.g. HIV integrase, protease, etc.) for X-ray crystallography studies. I also helped develop high-throughput screening assays based on ELISA for testing the inhibitory effect of a library of drug-like molecules.