Experience

Design Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Associate Director, Computational Chemistry

  • Feb 2023 - Present



Syros Pharmaceuticals

• United States
• Pharmaceutical Manufacturing
• 1 - 100 Employee

• Principal Scientist, Computational Chemistry

  • May 2021 - Jan 2023



Civetta Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientist, Computational Chemistry

  • Mar 2020 - Apr 2021



Jhuma Das Consulting, LLC

• Cary, North Carolina

• Founder

  • Jul 2019 - Mar 2020

  My life long passion to serve the life sciences research community to address unmet human health related needs by generating predictive structural models, and identifying drug targets, potential biomarkers (for diagnostic purposes), and biomolecules (for therapeutic purposes) using state-of-the-art computational methods. By de-convoluting information-rich, complex data sets derived from experiments, I design predictive models to find trends and patterns that ultimately can serve as diagnostic tool and/or guide rational drug design. My skills include (and not limited to) computational modeling, molecular simulations, computer progamming and bioinformatics. Show less



University of North Carolina at Chapel Hill

• United States
• Higher Education
• 700 & Above Employee

• Research Associate

  • Feb 2016 - Mar 2020

  • Young investigator Pilot and Feasibility Grant Award from Cystic Fibrosis Foundation• Combining cutting-edge experimental-computational technique to model mucin structures and study their structure-function relationship to aid rational pharmacological campaigns for respiratory diseases (e.g., Asthma, CF, COPD) in a joint effort comprising cross-functional team of biochemists, molecular biologists, and medical doctors• Studying the dynamics of normal versus pathological cystic fibrosis transmembrane regulator (CFTR) channel for finding the origin of Cystic Fibrosis Show less

• Postdoctoral Research Associate

  • Aug 2012 - Jan 2016

  •• Initiated, led and managed 8 successful computational modeling, protein design and drug discovery-based projects in fatal human disorders with drug targets CFTR, AMPK, ApoE in collaboration with team of physicists, chemists, biochemists and through training graduate and undergraduate students• Published 9 peer-reviewed papers in high-esteemed journals and 1 manuscript under review• Joint co-author and recipient of 10 million CPU hour allocations through successful grant proposals (Director’s Discretionary Program of Oak Ridge Leadership Computing Facility and Argonne National Laboratory, USA) Show less

• Postdoctoral Fellow

  • Sep 2010 - Aug 2012

  • Developed atomistic, coarse-grained and lattice models for charged surfactant coated surfaces using Monte Carlo and Molecular Dynamics simulations for designing optimal drug delivery vehicle



Parion Sciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Consultant

  • May 2018 - Dec 2018

  • Successfully completed Contract with Parion Sciences Inc. in the development of ligand-based predictive models to design novel therapeutic compounds via Quantitative Structure-Activity Relationships (QSAR) of investigational drugs • Successfully completed Contract with Parion Sciences Inc. in the development of ligand-based predictive models to design novel therapeutic compounds via Quantitative Structure-Activity Relationships (QSAR) of investigational drugs



Parion Sciences

• United States
• Biotechnology Research
• 1 - 100 Employee

• Consultant

  • Sep 2012 - Dec 2014

  • Led and managed contract-based data-driven drug screening campaign to identify hits for Cystic Fibrosis via combined in silico-experimental strategies in collaboration with Parion Sciences Inc. • Generated and interpreted data and written computational section of the grant, which resulted in direct determinant of receipt of $1.7 million grant by Parion Sciences, Inc. from Cystic Fibrosis Foundation Therapeutics, Inc. based on conducted collaborative research • Led and managed contract-based data-driven drug screening campaign to identify hits for Cystic Fibrosis via combined in silico-experimental strategies in collaboration with Parion Sciences Inc. • Generated and interpreted data and written computational section of the grant, which resulted in direct determinant of receipt of $1.7 million grant by Parion Sciences, Inc. from Cystic Fibrosis Foundation Therapeutics, Inc. based on conducted collaborative research



University of Missouri-Columbia

• United States
• Higher Education
• 700 & Above Employee

• Ph.D.

  • Aug 2005 - Aug 2010

  • Modeled, simulated and analyzed lipid, protein and water dynamics in biomolecular systems using integrated computational-experimental approaches • Taught and managed over 60 under-graduate students per semester for 4+ years through weekly Physics lab and problem solving classes • Modeled, simulated and analyzed lipid, protein and water dynamics in biomolecular systems using integrated computational-experimental approaches • Taught and managed over 60 under-graduate students per semester for 4+ years through weekly Physics lab and problem solving classes



Saha Institute of Nuclear Physics

• India
• Research Services
• 100 - 200 Employee

• Research Assistant

  • Sep 2003 - May 2005

  • Analyzed crystal structure databases to identify non-canonical base pairs and higher order structures in RNA, resulted in 1 publication; Built, managed and shared data on a web server • Analyzed crystal structure databases to identify non-canonical base pairs and higher order structures in RNA, resulted in 1 publication; Built, managed and shared data on a web server