Experience

Genospace

• United States
• IT Services and IT Consulting
• 1 - 100 Employee

• Principal Scientist

  • Oct 2014 - Present

  Cambridge, MA



N-of-One, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Scientific Editor

  • May 2013 - Sep 2014

  Lexington, MA • Synthesized scientific and clinical research on molecular alterations found in cancer for the purpose of identifying and translating information for clinical use • Identified actionable information, including relevant potential therapeutic approaches and clinical trials, for inclusion in clinical interpretation reports for molecular diagnostic tests • Generated and delivered reports for the clinical interpretation of genetic variants identified by sequencing-based tests for N-of-One… Show more • Synthesized scientific and clinical research on molecular alterations found in cancer for the purpose of identifying and translating information for clinical use • Identified actionable information, including relevant potential therapeutic approaches and clinical trials, for inclusion in clinical interpretation reports for molecular diagnostic tests • Generated and delivered reports for the clinical interpretation of genetic variants identified by sequencing-based tests for N-of-One business partners including: Foundation Medicine, OncoDNA, CeGaT, Guardant Health, Syapse, Fox Chase Cancer Center, and Mayo Clinic • Earned promotion to an editorial position within eight months of employment following demonstration of meticulous work with strong attention to detail • Edited and updated content in the N-of-One precision medicine knowledgebase • Participated in establishing curation policies and procedures • Participated in multi-disciplinary program teams (scientists, information technologists, clinicians) to satisfy client and business partner needs • Maintained up-to-date knowledge of cancer genetic targets, molecular tests, and emerging trends and provided regular updates to N-of-One executive and strategic teams

• Principal Scientist

  • Sep 2012 - Sep 2014



Beth Israel Deaconess Medical Center

• Research Associate

  • Sep 2011 - Sep 2012

  • Managed LPM projects focused on using integrative analysis of genomic data with clinical information to facilitate the advancement of personalized breast cancer care • Contributed to the analysis of data generated by the Stand Up to Cancer (SU2C) Dream Team "Targeting the PI3K Pathway in Women's Cancers" project • Implemented a range of bioinformatics tools for statistical analysis, biological interpretation, and visualization of high-throughput experimental data • Collected… Show more • Managed LPM projects focused on using integrative analysis of genomic data with clinical information to facilitate the advancement of personalized breast cancer care • Contributed to the analysis of data generated by the Stand Up to Cancer (SU2C) Dream Team "Targeting the PI3K Pathway in Women's Cancers" project • Implemented a range of bioinformatics tools for statistical analysis, biological interpretation, and visualization of high-throughput experimental data • Collected information on approximately 40 molecular tests and services aimed at facilitating the use of genetic information in clinical decision making to support the development of a breast cancer clinical variant database • Participated in the development and writing of all whole-genome analysis proposals: Played a major role in the preparation of the successful grant application for an award of whole-genome sequencing of eight genomes from the Complete Genomics Cancer Grant Program Show less



Harvard Medical School and Beth Israel Deaconess Medical Center

• Instructor in Pathology

  • Apr 2010 - Sep 2012

• Posdoctoral Research Fellow/NRSA Fellow

  • May 2007 - Feb 2011

  • Co-authored review articles and an educational book that discuss dysregulated apoptotic signaling in cancer and targeted therapeutic strategies aimed at inducing apoptosis • Searched the scientific literature and publicly available microarray databases to collect datasets that met predefined criteria for inclusion in bioinformatic analyses • Performed analyses of microarray data to identify genes found to be consistently differentially expressed in at least five of six independent… Show more • Co-authored review articles and an educational book that discuss dysregulated apoptotic signaling in cancer and targeted therapeutic strategies aimed at inducing apoptosis • Searched the scientific literature and publicly available microarray databases to collect datasets that met predefined criteria for inclusion in bioinformatic analyses • Performed analyses of microarray data to identify genes found to be consistently differentially expressed in at least five of six independent pancreatic cancer microarray datasets • Employed bioinformatics software for the biological interpretation and visualization of the results of the microarray data analyses • Delivered presentations at laboratory meetings and at interdepartmental meetings • Significantly contributed to the preparation and writing of grant applications



Harvard Medical School

• United States
• Higher Education
• 700 & Above Employee

• Teaching Assistant

  • Jan 2011 - May 2012

  • Developed lectures and course material, in a team effort with the course directors, for the Harvard Medical School course entitled “Introduction to Bioinformatics I: NGS - Data, Methods, Analysis, and Implications” • Arranged practicum sessions for the course that allowed students to gain hands-on training with valuable next-generation sequencing (NGS) analysis tools • Created student evaluations for the course and synthesized student responses

• Research Associate in Biomedical Informatics

  • Mar 2011 - Aug 2011



Brown University

• United States
• Higher Education
• 700 & Above Employee

• Research Assistant

  • 2003 - 2007

  • Performed the successful cloning, overexpression, and purification of various mutant and wild-type recombinant proteins to be used in structural studies • Trained undergraduate students in molecular biology techniques • Managed the purchasing of chemicals and other supplies needed for laboratory experiments

• Teaching Assistant

  • 2002 - 2003

  • Guided 15-20 chemistry students through laboratory experiments while providing a supportive learning environment • Explained the material covered in the experiments and in class lectures while in the laboratory and during individual meetings • Evaluated and graded lab quizzes, lab write-ups, lecture quizzes, and lecture exams



Biogen

• United States
• Biotechnology Research
• 700 & Above Employee

• Intern

  • 2004 - 2004

  • Performed protein expression and NMR techniques with various constructs to identify a target for structural analysis