Experience

Sonata Therapeutics

• United States
• Biotechnology Research
• 1 - 100 Employee

• Senior Scientist

  • May 2021 - Present

  Drug Discovery/Assay Development Drug Discovery/Assay Development


Freelance
• Egypt
• Human Resources
• 1 - 100 Employee
• Consultant/ Writer

  • Jul 2020 - May 2021


MD Anderson Cancer Center

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Research Scientist

  • Oct 2016 - Sep 2019

  * My research focused on the relationship between chronic inflammation and colorectal cancer, with an emphasis on lipoxygenase actions/ lipid mediator signaling *Demonstrated gene-diet interactions in a mouse model of colorectal cancer with potential to inform and improve chemoprevention strategies in humans *Proposed research plan to further investigate the role of 15-lipoxygenase-1 and TGF-β signaling in pathogenesis/prevention of colitis-associated colon cancer (revision submitted, pending review) * Authorship on 3 review articles, including one focused on lipid signaling in tumor associated macrophages *Expanded the lab’s exploration of immune mechanisms in colitis and cancer by collaborating with our flow cytometry core to develop and optimize a flow cytometry panel * Developed leadership skills through participation in MDACC's Heart of Leadership Program Show less



Brigham and Women's Hospital

• United States
• Hospitals and Health Care
• 700 & Above Employee

• Postdoctoral fellow

  • Jun 2010 - Aug 2016

  * Conducted research on the biosynthesis and signaling of specialized pro-resolving lipid mediators (SPMs) in inflammatory diseases of the airway; experience with models of acute lung injury and infection *Led research efforts revealing multiple mechanisms of action for the efficacy of resolvin D3 (RvD3) in promoting resolution of acute lung injury (ALI), suggesting possible intervention strategies to limit severity of ALI and accelerate recovery of lung function *Uncovered distinctions in lipoxygenase expression and pro-resolving signaling in strains of mice with different capacities to clear fungal (cryptococcal) pneumonia, demonstrating the importance of this aspect of host biology in limiting infection *Contributed to additional collaborations focused on pro-resolving signals in lung injury and infection, leading to 5+ peer-reviewed publications * Training in HPLC analysis of lipids * Collaborated with multiple groups both within and outside BWH/HMS, leading to authorship on several publications Show less

• Postdoctoral fellow

  • Dec 2009 - May 2010

  * Research on mouse models of pancreatic cancer

• Graduate Student

  • Sep 2004 - Dec 2009

  * My research focused on the role of cyclooxygenase-2 in the pathogenesis of pancreatic cancer, leading to successful completion of the PhD program in Molecular Carcinogenesis *Characterized a mouse model of COX-2 driven pancreatitis and pancreatic cancer, showing the impact of chronic inflammation on pathogenesis of these diseases *Demonstrated the efficacy of COX-2 inhibition as a chemoprevention strategy in the BK5.COX-2 mouse model *Collaborator on research showing tumor-promoting roles for COX-2 in models of prostate and bladder cancer; authorship on 3+ papers* Extensive experience with mouse handling, colony management* Thorough training in multiple molecular biology/biochemistry techniques (PCR, Western blotting, ELISA, histology and immunohistochemistry) Show less