Experience

Mazen Animal Health - Oral Vaccines
• United States
• Biotechnology Research
• 1 - 100 Employee
• Senior Principal Scientist, Biochemistry Lead

  • Jan 2023 - Present


BASF

• Germany
• Chemical Manufacturing
• 700 & Above Employee

• Principal Scientist

  • Aug 2018 - May 2022

  Protein Discovery, Structure-Function & Protein Engineering. - Managing several scientific projects and collaborations with 3rd parties and Universities. Driving efforts in the exploration and validation of innovative ideas and technologies. Coaching and mentoring junior scientists. - Developed a new concept of protein promotion pipeline by fully mining the delta-endotoxin space with an expert understanding of the various domain boundaries, structural completeness, and optimized clustering of protein sequences. This approach led to screening >200 genes, resulting in the discovery of 30+ novel insecticidal protein candidates with the desired spectrum of activity and potentially a new site of action. - Demonstrated (via supervision) significant improvement of overall protein expression rate from 50% to >95% by incorporation of appropriate QC steps and using alternative expression protocols, including successful expression of more than 25 difficult-to-express proteins. - Coordinated and supervised screening and extensive characterization of ~200 native microbial strains for insecticidal activity ultimately identifying multiple novel protein targets. Show less



Bayer CropScience

• Germany
• Chemical Manufacturing
• 1 - 100 Employee

• Principal Scientist

  • 2016 - Aug 2018

  Leading cross-functional international team efforts in protein structure determination and protein engineering. Interaction with multiple scientific projects and teams from discovery and optimization to regulatory reviews of agronomic traits, using structural biology as a collaborative tool.

• Senior Scientist

  • 2013 - 2016

  Management of Protein Engineering groupProtein crystallography, structure-function relationships, employment of protein engineering techniques for functional improvement and/or mode of action studies of target proteins

• Scientist

  • Nov 2009 - 2013

  Discovery of novel pesticidal proteins; protein purification from native and recombinant strains, biochemical protein characterization



Athenix

• Advertising Services
• 1 - 100 Employee

• Scientist

  • Feb 2007 - Nov 2009

  Discovery of novel pesticidal proteins. High-throughput screening bacterial strains for specific protein-based pesticidal activity with emphasis on plant-feeding piercing-sucking insects and plant-parasitic nematodes in order to provide resistance to agronomic crops. Discovery of novel pesticidal proteins. High-throughput screening bacterial strains for specific protein-based pesticidal activity with emphasis on plant-feeding piercing-sucking insects and plant-parasitic nematodes in order to provide resistance to agronomic crops.



The University of Kansas

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Research Associate

  • Feb 2004 - Jan 2007

  Department of Molecular Biosciences and Department of Medicinal Chemistry. Biochemistry, Structural Biology. Investigation of multidomain peptide synthetases involved in siderophore production in Pseudomonas aeruginosa. Elucidation of human P450 2E1 cytochrome structure in order to predict substrate specificity and to design selective inhibitors for clinical use. Department of Molecular Biosciences and Department of Medicinal Chemistry. Biochemistry, Structural Biology. Investigation of multidomain peptide synthetases involved in siderophore production in Pseudomonas aeruginosa. Elucidation of human P450 2E1 cytochrome structure in order to predict substrate specificity and to design selective inhibitors for clinical use.