Experience

Invitae

• United States
• Biotechnology Research
• 700 & Above Employee

• Clinical Genomics Scientist

  • Jul 2021 - Present

  -Assessment and classification of complex variants in the field of Pediatric, Reproductive (Carrier testing), Ophthalmologic, Metabolic, Neurologic, and Cancer. -Gene curation and clinical report criteria curation -Analysis and report writing of patient data results by reviewing clinical details correlating with the variant pathogenicity -Assessment and classification of complex variants in the field of Pediatric, Reproductive (Carrier testing), Ophthalmologic, Metabolic, Neurologic, and Cancer. -Gene curation and clinical report criteria curation -Analysis and report writing of patient data results by reviewing clinical details correlating with the variant pathogenicity



ActX, Inc.

• United States
• Biotechnology Research
• 1 - 100 Employee

• Lead Geneticist

  • Jun 2020 - Jul 2021

• Geneticist

  • Jun 2016 - Jun 2020

  -Microarray/Sequencing data (Pharmacogenomics, rare disease risks, and carrier status) interpretation, review and release to healthcare providers and patient -Pharmacogenomics gene haplotype constructions for the internal database and creation of contents based on each of the different metabolizer statuses -Review of internal clinical knowledgebase and update contents of drug interactions based on the latest medical studies including but not limited to literature reviews and CPIC/FDA… Show more -Microarray/Sequencing data (Pharmacogenomics, rare disease risks, and carrier status) interpretation, review and release to healthcare providers and patient -Pharmacogenomics gene haplotype constructions for the internal database and creation of contents based on each of the different metabolizer statuses -Review of internal clinical knowledgebase and update contents of drug interactions based on the latest medical studies including but not limited to literature reviews and CPIC/FDA guidelines -Lead and manage a team of Genetic Counselors, Geneticists, and Pharmacists -Perform quality improvement and assessment of the lab (heavily involved with setting up and maintaining the CAP/CLIA credentials) -Establishment or verification of laboratory test performance specifications by setting up RT-PCR and proficiency testing methods -Liaise with external laboratories and train and certify external clients, such as health systems, on modifying and customizing the internal database and releasing their patient results -Research and troubleshoot issues on request of the Clinical Consultant -Collaboration with software developers or computational team for building and troubleshooting the internal database algorithms and logics



University of Washington

• United States
• Higher Education
• 700 & Above Employee

• Postdoctoral Fellow

  • Feb 2014 - Jul 2015

  Research on Aging and Mitochondrial dysfunction. • Intervention studies for mitochondrial disease Ndufs4 -/- mouse model • Define mechanistic basis to understand the role of mTOR signaling in mitochondrial disease • Intervention studies to limit accumulation of glycolytic intermediates and to activate AMPK which can regulate mitochondrial biogenesis and aging in C.elegans model system. • Involved with RNAseq project and analysis Research on Aging and Mitochondrial dysfunction. • Intervention studies for mitochondrial disease Ndufs4 -/- mouse model • Define mechanistic basis to understand the role of mTOR signaling in mitochondrial disease • Intervention studies to limit accumulation of glycolytic intermediates and to activate AMPK which can regulate mitochondrial biogenesis and aging in C.elegans model system. • Involved with RNAseq project and analysis



Albert Einstein College of Medicine

• United States
• Higher Education
• 700 & Above Employee

• Graduate Student (Ph.D.)

  • Aug 2008 - Jan 2014

  Research on Aging, Longevity and Human Genetics. PROJECT 1 • Thesis: "A functional genomics approach to elucidate the role of genome maintenance in human longevity” i) Initiated and set up multiplex targeted sequence capture method for next-generation sequencing for the discovery of genetic variation in the candidate pathway genes ii) Genetic variation study by performing multiple association analysis iii) Carried out functional analysis using a cell culture model to… Show more Research on Aging, Longevity and Human Genetics. PROJECT 1 • Thesis: "A functional genomics approach to elucidate the role of genome maintenance in human longevity” i) Initiated and set up multiplex targeted sequence capture method for next-generation sequencing for the discovery of genetic variation in the candidate pathway genes ii) Genetic variation study by performing multiple association analysis iii) Carried out functional analysis using a cell culture model to ascertain the functional relevance of longevity-associated gene variants (ATR, SIRT1, and SIRT6) iv) Research involved DNA sample prep, designing target capture panel, multiplex sequencing, and analyzing the genomic data PROJECT 2 • Evaluate the role of SIRT1 in longevity and cancer i) Population study of SIRT1 gene in association with longevity and lipid profile ii) Studied tumor suppressor role of SIRT1 iii) Identified excessive allelic loss and novel mutations of SIRT1 in cancer cell lines Show less Research on Aging, Longevity and Human Genetics. PROJECT 1 • Thesis: "A functional genomics approach to elucidate the role of genome maintenance in human longevity” i) Initiated and set up multiplex targeted sequence capture method for next-generation sequencing for the discovery of genetic variation in the candidate pathway genes ii) Genetic variation study by performing multiple association analysis iii) Carried out functional analysis using a cell culture model to… Show more Research on Aging, Longevity and Human Genetics. PROJECT 1 • Thesis: "A functional genomics approach to elucidate the role of genome maintenance in human longevity” i) Initiated and set up multiplex targeted sequence capture method for next-generation sequencing for the discovery of genetic variation in the candidate pathway genes ii) Genetic variation study by performing multiple association analysis iii) Carried out functional analysis using a cell culture model to ascertain the functional relevance of longevity-associated gene variants (ATR, SIRT1, and SIRT6) iv) Research involved DNA sample prep, designing target capture panel, multiplex sequencing, and analyzing the genomic data PROJECT 2 • Evaluate the role of SIRT1 in longevity and cancer i) Population study of SIRT1 gene in association with longevity and lipid profile ii) Studied tumor suppressor role of SIRT1 iii) Identified excessive allelic loss and novel mutations of SIRT1 in cancer cell lines Show less



Seoul National University

• Higher Education
• 700 & Above Employee

• Research Scientist

  • Aug 2006 - Jun 2008

  Research on Cancer Cell biology. • Understanding the role of AMPK in cancer cell growth inhibition and p38 MAPK activation

• Graduate Student (M.S.)

  • Aug 2004 - Aug 2006

  Research on Cancer Cell biology. PROJECT 1 • Thesis: “AMPK and p38 MAPK mediates 8-chloro-cAMP-induced growth inhibition and apoptosis” i) Cell signaling study in cancer cells using pharmacological activator, inhibitor, and gene knock-down system PROJECT 2 • Rap1 and p38 MAPK mediate 8-chloro-cAMP-induced growth inhibition in mouse fibroblast DT cells



Seoul National University

• Higher Education
• 700 & Above Employee

• Volunteer Researcher

  • Dec 2003 - Feb 2004

  • Established Rap1 KO cancer cell lines and characterized signaling mechanism of 8-chloro-cAMP • Established Rap1 KO cancer cell lines and characterized signaling mechanism of 8-chloro-cAMP



The National Institutes of Health

• United States
• Biotechnology Research
• 700 & Above Employee

• Volunteer Researcher

  • Nov 2002 - Jan 2003

  • Studied signaling mechanism of PLC-gamma2 in response to engagement of the B-cell receptor. • Studied signaling mechanism of PLC-gamma2 in response to engagement of the B-cell receptor.