Jacob Brenza

Lead Mechanical Engineer at PolarisAR
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Contact Information
us****@****om
(386) 825-5501
Location
Greater Boston
Languages
  • English Native or bilingual proficiency

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Bio

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Experience

    • United States
    • Medical Equipment Manufacturing
    • 1 - 100 Employee
    • Lead Mechanical Engineer
      • Sep 2022 - Present

    • United States
    • Medical Equipment Manufacturing
    • 700 & Above Employee
    • Senior Design Engineer
      • Sep 2021 - Sep 2022

    • United States
    • Medical Equipment Manufacturing
    • 100 - 200 Employee
    • Manager, Hip Engineering
      • May 2021 - Sep 2021

    • Senior Design Engineer
      • Aug 2019 - May 2021

    • United States
    • Medical Equipment Manufacturing
    • 1 - 100 Employee
    • Senior Product Development Engineer
      • Sep 2018 - Aug 2019

      • Key contributor in multiple cross-functional groups in small orthopedic oncology company• Managed all verification and validation activities for the company including set-up and validation of new cleaning lines, packaging systems, sterilization validations, mechanical testing, cadaver labs, and biocomp testing• Led project teams focused on developing 3D printed patient specific implants, creating customized single use instruments, and updating existing products to 3D printed parts• Developed implant and instrument designs, wrote specs and procedures, authored engineering rationales and technical reports, and maintained design controls• Primary engineering contributor to 510(k) submissions Show less

    • Product Development Engineer
      • Aug 2016 - Sep 2018

      • Created and expanded 3D printing capabilities and supply chain including qualifying and validating machines• Developed and fully characterized a proprietary porous structure for 3D printed implants• Designed and optimized instruments for three projects• Provided support via engineering drawings, technical reports, and design controls for the company’s first two regulatory clearances

    • United States
    • Higher Education
    • 700 & Above Employee
    • Volunteer Assistant Throws Coach
      • Oct 2014 - Aug 2016

      > Coached a small group of elite athletes. > Performed daily practice programming, scheduling, technical analysis, video review, strength and conditioning programing, weightlifting analysis, and biomechanical analysis. > Coached 3 All Americans, 1 NCAA National Champion, and 1 Olympic Qualifier > Coached a small group of elite athletes. > Performed daily practice programming, scheduling, technical analysis, video review, strength and conditioning programing, weightlifting analysis, and biomechanical analysis. > Coached 3 All Americans, 1 NCAA National Champion, and 1 Olympic Qualifier

    • United States
    • Chemical Manufacturing
    • Bioengineer
      • Aug 2014 - Aug 2016

      > Head of all research and development of lateral flow diagnostics. Successfully developed and managed 7 completely new products that are now in full production > Head of Product management for full line of products across multiple target areas and groups. Made over 10% increases in production speed, test sensitivity, specificity, and reproducibility for 4 of the top 5 selling products > Head of QA/QC. Dealt with all quality roles involving new products, manufacturing, and the testing and distribution of final products > Led a complete overhaul of document systems, procedures, and inventory systems to begin preparations for FDA audits > Created and managed plan for development and future FDA approval for next generation of one of the world’s most popular HIV tests Show less

    • United States
    • Pharmaceutical Manufacturing
    • 700 & Above Employee
    • Research Engineer Intern
      • May 2013 - Sep 2013

      > Worked in the antibody drug development group > Developed and characterized a custom immortalized cell line with built in assay to measure potential drug efficacy for a designated target > Contributed to large scale antibody drug products currently in FDA testing stages > Worked in the antibody drug development group > Developed and characterized a custom immortalized cell line with built in assay to measure potential drug efficacy for a designated target > Contributed to large scale antibody drug products currently in FDA testing stages

    • Higher Education
    • 700 & Above Employee
    • Research Engineer Intern
      • Sep 2011 - Jun 2012

      > Created a custom protein for testing dual antibody targeting and its effect on drug uptake > Cloned the genetic binding sequence of an antibody from hybridoma and genetically engineered it to include the binding domain of another antibody along with a link, tag, and other accessory segments > Produced, purified, and tested the target protein in insect cells > Played large role in work behind the paper titled “Dual targeting of therapeutics to endothelial cells: collaborative enhancement of delivery and effect” published in Federation of American Societies for Experimental Biology Journal in August 2015 Show less

    • United States
    • Hospitals and Health Care
    • 700 & Above Employee
    • Research Engineer Intern
      • May 2011 - Aug 2011

      > Performed biomechanical experiments focused on shoulder injury and repair > Processed and examined CAT scan and MRI images to produce fully functioning 3D images. Processed images and performed corresponding computational analysis > Performed initial design and prototyping of placement assistance device for shoulder surgeries > Played large role in work behind the paper titled “Construct damage and loosening around glenoid implants: A longitudinal micro-CT study of five cadaver specimens.” published in Journal of Orthopedic Research in December 2015 Show less

Education

  • University of Pennsylvania
    Bachelor of Engineering (B.E.), Bioengineering and Biomedical Engineering
    2010 - 2014
  • University of Pennsylvania

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