Jaime Martinez Grundman

Postdoctoral Fellow at Harvard University
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Contact Information
us****@****om
(386) 825-5501
Location
US

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Experience

    • United States
    • Higher Education
    • 700 & Above Employee
    • Postdoctoral Fellow
      • Mar 2023 - Present

      Biochemical and structural characterization of neofunctionalized plant metabolic enzymes Biochemical and structural characterization of neofunctionalized plant metabolic enzymes

    • United States
    • Higher Education
    • 700 & Above Employee
    • Graduate Student
      • 2016 - 2023

      Laboratory of Dr. Juliette Lecomte ∗ Discovered pH- and redox-related determinants of heme coordination in an algal hemoglobin via modified interactions at the active site periphery and co-led collaboration with MD/QM computational group (University of Buenos Aires), resulting in 2 publications, 6 conference oral/poster presentations, and 1 database entry (PDB ID 6CII). ∗ Characterized structure and stability in a consensus-designed hemoglobin with NMR spectroscopy, chemical denaturation, and heme binding thermodynamics, shedding light on sequence determinants of function (3 conference posters, manuscript in progress). ∗ Initiated study of a deep-sea piezophilic hemoglobin, focused on oligomeric properties (via X-ray crystallography, NMR, and AUC) and unusual oxidative reactivity (with mass spectrometry and stopped- flow kinetics), as part of the NSF Extreme Biology/Biophysics collaborative research network (2 conference oral/poster presentations, 1 database entry [PDB ID 7TT9], manuscript in progress). ∗ Senior lab management for 2+ years; one-on-one mentoring of 4 junior lab members; assisted in writing an accepted NSF EAGER grant to biophysically characterize structural and non-structural proteins of SARS-CoV-2 in collaboration with the Barrick Lab (JHU). Show less

    • United States
    • Higher Education
    • 700 & Above Employee
    • Laboratory Technician
      • May 2015 - Aug 2015

      Laboratory of Dr. Edward P. Nikonowicz∗ Summer employment continuing on undergraduate projects

    • Undergraduate Research Assistant
      • Aug 2013 - May 2015

      Laboratory of Dr. Edward Nikonowicz∗ Designed and purified chimeric ribosomal proteins from B. anthracis and E. coli to study coupling between conformational disorder (NMR spectroscopy) and rRNA affinity (EMSA); took part in summer research experiences with 2 accompanying poster symposia.

    • Research Fellow
      • May 2014 - Aug 2014

      Laboratory of Dr. Edward Nikonowicz∗ Summer employment continuing on undergraduate projects

    • Undergraduate Research Assistant
      • Sep 2012 - Jul 2013

      Laboratory of Dr. Weiwei Zhong∗ Carried out C. elegans genome-wide knockdowns and used automated imaging to understand genetic interactions regulating nematode body size

Education

  • The Johns Hopkins University
    Doctor of Philosophy (Ph.D.), Molecular Biophysics
    2015 - 2023
  • Rice University
    Bachelor of Science (B.S.), Biochemistry & Cell Biology
    2011 - 2015

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