Adjunct Professor of Bio-AI Convergence Department

• Mar 2022 - Present

Chief Executive Officer

• Jun 2022 - Present

Chief Executive Officer

• Sep 2018 - Present

Research Associate

• Sep 2016 - Aug 2018

1) Research of Norovirus non-structural proteins, especially structure and functional relationship of NTPase (called P41 or NSP2). This viral NTPase is the most highly conserved proteins among single stand RNA virus including Rhinovirus (Common cold), Hepatitis A and FMDV (Foot and Mouth Disease Virus) and essential for the virus replication. With all respect of requirements to be a good antivirus target, various research effort were hampered by lack of biochemical studies as well as functional… Show more 1) Research of Norovirus non-structural proteins, especially structure and functional relationship of NTPase (called P41 or NSP2). This viral NTPase is the most highly conserved proteins among single stand RNA virus including Rhinovirus (Common cold), Hepatitis A and FMDV (Foot and Mouth Disease Virus) and essential for the virus replication. With all respect of requirements to be a good antivirus target, various research effort were hampered by lack of biochemical studies as well as functional studies due to the heavy aggregation or instabilities of the protein. However recently we have made a break through of successful purification and X-ray structure determination. Currently I am working on Norovirus NTPase function. 2) Development of GPU computing and lead chemical screening algorithms using in-silico protein structure models including X-ray structures we recently determined. Modern day graphic card contains thousand computing cores similar to CPU called GPU. More and more applications are utilizing GPUs for computing however existing soft wares for drug screening lack GPU calculation abilities, not to mention about its inefficiency of sorting best candidate compounds in-silico. I am currently developing sorting and scoring algorithm of anti-viral lead compounds based on Neural network based algorithm (machine learning ) capable of processing PDB and small molecule database (big data). 3) In collaboration with one of the lab member, I am also working on Rotavirus NSP1 protein which was not purified before. We successfully purified and trying to define its function in biochemistry experiment.

PostDoc Associate

• Sep 2012 - Sep 2016

My responsibilities includes • Lead roles in RO1 Grant Funded Project (On going): Structural studies of Norovirus NTPase using X-ray crystallography • Lead roles in RO1 Grant Funded Project (On going): Structural studies of Rotavirus NSP1 protein using X-ray crystallography • Supporting roles in collaborative Project (Successfully finished): Structural studies of influenza virus NS1 protein using X-ray crystallography • Lead roles in developing future RO1 project (In progress):… Show more My responsibilities includes • Lead roles in RO1 Grant Funded Project (On going): Structural studies of Norovirus NTPase using X-ray crystallography • Lead roles in RO1 Grant Funded Project (On going): Structural studies of Rotavirus NSP1 protein using X-ray crystallography • Supporting roles in collaborative Project (Successfully finished): Structural studies of influenza virus NS1 protein using X-ray crystallography • Lead roles in developing future RO1 project (In progress): virtual screening of anti-viral drugs against essential Norovirus proteins and structural validation and optimization. • Lead roles in developing future RO1 project (In progress): Developing Nano-disc imaging system for viral membrane proteins using cryo-EM. also I am serving as a system administrator for Linux systems (Fedora & CenOS) I self taught myself few computer languages including C, Python, Java, JavaScript.

Research Assistant

• 2001 - 2002

• Supporting roles in the research department: Development, production and evaluation of small molecules which can enhance fish immune system for fish farming industry • Supporting roles in the research department: Development, production and evaluation of small molecules which can enhance fish immune system for fish farming industry